Navigation Links
New research questions basic tenet of neuron function

New findings by researchers at UT Southwestern Medical Center challenge one of the established views of how nerve cells communicate with one another.

Every time we move, feel emotions, think or remember, the nerve cells, or neurons, in our body transmit messages to one another via chemical signals called neurotransmitters. Within neurons are tiny organelles called synaptic vesicles that sequester neurotransmitters and release them when needed into the synapse, or space between nerve cells, where the chemical signal is transmitted to other neurons.

It is known that synaptic vesicles release their neurotransmitters in two different "modes" ?one when the neuron is stimulated and actively relaying a message, and the other through spontaneous release when the neuron is "at rest," or inactive. Until now it was believed that the same synaptic vesicles were responsible for releasing neurotransmitters in both modes.

However, new research by UT Southwestern scientists appearing in the Feb. 17 issue of the journal Neuron suggests that two distinct types of synaptic vesicles are responsible for the two different modes of neurotransmitter release ?one type of vesicle for spontaneous release, another vesicle associated with activity-dependent release.

"These findings question one of the core tenets of synaptic function and reveal significant complexity in organization of synaptic vesicles within individual synapses," said Dr. Ege Kavalali, assistant professor in the Center for Basic Neuroscience and of physiology at UT Southwestern and senior author on the study.

Neurotransmitters regulate many different aspects of mood, cognition and behavior, such as emotional state, reactions to stress, pain, and the physical drives of sleep, appetite and sexuality.

A better understanding of such fundamental mechanisms of neurotransmitter release will aid researchers in their investigations of psychiatric disorders and neurological disorder
'"/>

Source:UT Southwestern


Page: 1 2

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. U of M researcher examines newly emerging deadly disease
3. NYU researchers simulate molecular biological clock
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. Vital step in cellular migration described by UCSD medical researchers
6. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
7. UCSD researchers maintain stem cells without contaminated animal feeder layers
8. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
9. New protein discovered by Hebrew University researchers
10. First real-time view of developing neurons reveals surprises, say Stanford researchers
11. New research indicates a troubled greenhouse is brewing
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New research questions basic tenet neuron function

(Date:9/2/2014)... touch a hot oven, you rapidly pull your hand ... in sensing and responding to such painful stimuli, they ... researchers have made a surprising discovery about the role ... and have built a structural model of the molecule. ... , may help direct new strategies to treat pain ...
(Date:9/1/2014)... amount of research shows an association between TV viewing ... Now, a new Cornell University study points out that ... lead people to eat twice as much as other ... movie while snacking your mouth will see more action ... new article just published in the Journal of ...
(Date:9/1/2014)... quality of the U.S. diet showed some modest improvement ... a reduction in the consumption of unhealthy trans fats, ... the rich and the poor. , , An unhealthy ... some cancers. Eating a healthy diet is an important ... Evaluating population trends in diet quality is important because ...
Breaking Biology News(10 mins):Surprising new role for calcium in sensing pain 2Surprising new role for calcium in sensing pain 3Can action movies make you fat? 2Quality of US diet improves, gap widens for quality between rich and poor 2Quality of US diet improves, gap widens for quality between rich and poor 3
... and Washington DC (July 27, 2009) According to a ... Making , a large-scale, covert anthrax attack on a ... extremely effective public health response, primarily because of expected ... to it. The article "Predicting Hospital Surge after ...
... overall nation-wide estimate of the tiger population brought a ... by the Nepal Government,s Department of National Parks and ... 194) breeding tigers in the wild within the ... estimate was jointly implemented by the DNPWC, Department of ...
... Atrophy is the second-leading cause of infant mortality in the ... Iowa State University,s College of Veterinary Medicine, would like to ... slide off the list altogether. , Most Spinal Muscular Atrophy ... or deleted gene called Survival Motor Neuron 1 (SMN1) that ...
Cached Biology News:Bioterrorism and disaster preparedness explored in special issue of Medical Decision Making 2121 breeding tigers estimated to be found in Nepal 2ISU researchers find possible treatment for spinal muscular atrophy 2
(Date:8/29/2014)... , Aug. 29, 2014 /PRNewswire/ - iCo Therapeutics ... today reported financial results for the six months ... are expressed in Canadian dollars and presented under ... Quarter 2014 Highlights , Announced top-line ... (VA) primary endpoint for subjects enrolled in the ...
(Date:8/29/2014)... (PRWEB) August 29, 2014 Due to a ... last week, the Adult Stem Cell Technology Center, LLC ( ... support stem cell therapy research that might benefit ALS patients. ... cells for new stem cell technologies and therapeutic applications, FRC ... Ice Bucket Challenge donors who wish not to support ...
(Date:8/28/2014)... USA (PRWEB) August 28, 2014 SPIE ... of Physics and Optical Science and Director of the ... of North Carolina at Charlotte, and co-founder and Chairman ... to serve as the 2015 Vice President of SPIE, ... 2014 President Philip Stahl announced recent election results at ...
(Date:8/28/2014)... 28, 2014 “This kit has an improved ... from 0 to 150 ppb,” said Mark Tess, PhD, Mycotoxin ... benefit to plant owners and USDA-GIPSA inspection agencies that have ... Testing can take place in a matter of minutes with ... plant test the feed and grain before accepting it, but ...
Breaking Biology Technology:iCo Therapeutics Announces Second Quarter 2014 Financial Results 2iCo Therapeutics Announces Second Quarter 2014 Financial Results 3iCo Therapeutics Announces Second Quarter 2014 Financial Results 4The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 2The Adult Stem Cell Technology Center, LLC Declines ALS Ice Bucket Challenge Donors Wishing to Support Ethical Research for New Stem Cell Therapies 3Glenn Boreman, UNC Professor and Plasmonics Co-Founder, Elected to SPIE Presidential Chain 2
... CORVALLIS, Ore. Inkjet printers, a low-cost technology that in ... soon offer similar benefits for the future of solar energy. ... for the first time to create successful "CIGS" solar devices ... by 90 percent and will significantly lower the cost of ...
... HumanTouch, LLC welcomes David Meyer to our team as the ... tasked with assisting the executive leadership in building upon the ... health Information technology (IT) experience and expertise HumanTouch has been ... Senior Executive with more than 20 years of diverse experience ...
... ANGELES, June 28, 2011 Genesis Biopharma, Inc. ... therapies, is holding a conference call with the ... Noon Eastern (9:00 a.m. Pacific).  The Company,s Chairman ... provide an update on the business, and discuss ...
Cached Biology Technology:Inkjet printing could change the face of solar energy industry 2HumanTouch Welcomes David Meyer as Vice President of HumanTouch's new Health Solutions Division 2Genesis Biopharma Conference Call and Webcast Reminder 2
Request Info...
Anti-ZFP200 Family: Zinc Finger Peptide Sequence: CGKSFNHKTNLNKHER...
Donor feline serum and plasma...
Collected from sexually mature, mixed sex, mixed breed cats. Physiochemical constituents are measured to ensure lot-to-lot consistency....
Biology Products: