Navigation Links
New research questions basic tenet of neuron function

New findings by researchers at UT Southwestern Medical Center challenge one of the established views of how nerve cells communicate with one another.

Every time we move, feel emotions, think or remember, the nerve cells, or neurons, in our body transmit messages to one another via chemical signals called neurotransmitters. Within neurons are tiny organelles called synaptic vesicles that sequester neurotransmitters and release them when needed into the synapse, or space between nerve cells, where the chemical signal is transmitted to other neurons.

It is known that synaptic vesicles release their neurotransmitters in two different "modes" ?one when the neuron is stimulated and actively relaying a message, and the other through spontaneous release when the neuron is "at rest," or inactive. Until now it was believed that the same synaptic vesicles were responsible for releasing neurotransmitters in both modes.

However, new research by UT Southwestern scientists appearing in the Feb. 17 issue of the journal Neuron suggests that two distinct types of synaptic vesicles are responsible for the two different modes of neurotransmitter release ?one type of vesicle for spontaneous release, another vesicle associated with activity-dependent release.

"These findings question one of the core tenets of synaptic function and reveal significant complexity in organization of synaptic vesicles within individual synapses," said Dr. Ege Kavalali, assistant professor in the Center for Basic Neuroscience and of physiology at UT Southwestern and senior author on the study.

Neurotransmitters regulate many different aspects of mood, cognition and behavior, such as emotional state, reactions to stress, pain, and the physical drives of sleep, appetite and sexuality.

A better understanding of such fundamental mechanisms of neurotransmitter release will aid researchers in their investigations of psychiatric disorders and neurological disorder s such as mental retardation, autism, depression and epilepsy, all of which have been linked to abnormal neurotransmitter function, said Dr. Kavalali.

In neuronal cell cultures, the researchers labeled synaptic vesicles with a fluorescent dye and observed how and when the vesicles released neurotransmitters, both when the neurons were at rest and when they were active. From these observations, as well as data gathered from electrophysiological techniques, the researchers found two distinct types of vesicles.

"The functional differences of these two sets of vesicles may be the result of differences in the protein and/or lipid composition of the vesicles," Dr. Kavalali said. "Higher-resolution analysis is needed to test whether the two sets of vesicles are indeed distinct."

Dr. Kavalali said that if the two types of vesicles have different molecular compositions, as their findings suggest, those differences may make it possible to independently regulate spontaneous and activity-dependent neurotransmitter release. Spontaneous release is thought to play a role in the development of the neural circuitry in the brain and body, while activity-dependent release is responsible for functions such as learning and memory.


'"/>

Source:UT Southwestern


Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. U of M researcher examines newly emerging deadly disease
3. NYU researchers simulate molecular biological clock
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. Vital step in cellular migration described by UCSD medical researchers
6. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
7. UCSD researchers maintain stem cells without contaminated animal feeder layers
8. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
9. New protein discovered by Hebrew University researchers
10. First real-time view of developing neurons reveals surprises, say Stanford researchers
11. New research indicates a troubled greenhouse is brewing
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/13/2017)... , Feb. 13, 2017 Former 9/11 Commission ... Judiciary Committee, Janice Kephart of Identity Strategy ... Donald Trump,s "Executive Order: Protecting the Nation ... 27, 2017):  "As President Trump,s ,Travel Ban, ... has now essentially banned the travel ban, it is ...
(Date:2/8/2017)... , Feb. 7, 2017 Report Highlights ... The global synthetic-biology ... $11.4 billion by 2021, growing at a compound annual growth ... An overview of the global markets for synthetic biology. - ... for 2016, and projections of compound annual growth rates (CAGRs) ...
(Date:2/7/2017)... 7, 2017 Ipsidy Inc. ( ... [OTC: IDGS], ("Ipsidy" or the "Company") a provider of ... services, is pleased to announce the following changes as ... Effective January 31, 2017, Philip D. Beck ... and President.  An experienced payment industry professional and public ...
Breaking Biology News(10 mins):
(Date:2/21/2017)... /PRNewswire/ - SQI Diagnostics Inc. ("SQI" or the "Company") (TSX-V: SQD; ... three months ended December 31, 2016. SQI ... diagnostics company that develops and commercializes proprietary technologies and products ... ... commercial milestones achieved in fiscal 2016," said Andrew Morris ...
(Date:2/21/2017)... ... ... The medical potential of stem cells is both extensive and astounding, and ... their differentiating characteristics. Stem cells are unique as the have the potential to renew ... tissue or organic-specific cells with special functions. , Stem cell therapy in the ...
(Date:2/21/2017)... 21, 2017  Lexus, a returning partner of the Amgen ... and exclusive automobile partner of the men,s and women,s events for ... The 2017 Amgen Tour of California will ... of the best professional cycling teams in the world racing from ... four-day Amgen Breakaway from Heart Disease TM Women,s ...
(Date:2/20/2017)... (PRWEB) , ... February 20, 2017 , ... ... to announce that it has been approved for full, active membership in the ... Dallas, Texas, was founded by Chief Executive Officer Jeff Olson in ...
Breaking Biology Technology: