Navigation Links
New research questions basic tenet of neuron function

New findings by researchers at UT Southwestern Medical Center challenge one of the established views of how nerve cells communicate with one another.

Every time we move, feel emotions, think or remember, the nerve cells, or neurons, in our body transmit messages to one another via chemical signals called neurotransmitters. Within neurons are tiny organelles called synaptic vesicles that sequester neurotransmitters and release them when needed into the synapse, or space between nerve cells, where the chemical signal is transmitted to other neurons.

It is known that synaptic vesicles release their neurotransmitters in two different "modes" ?one when the neuron is stimulated and actively relaying a message, and the other through spontaneous release when the neuron is "at rest," or inactive. Until now it was believed that the same synaptic vesicles were responsible for releasing neurotransmitters in both modes.

However, new research by UT Southwestern scientists appearing in the Feb. 17 issue of the journal Neuron suggests that two distinct types of synaptic vesicles are responsible for the two different modes of neurotransmitter release ?one type of vesicle for spontaneous release, another vesicle associated with activity-dependent release.

"These findings question one of the core tenets of synaptic function and reveal significant complexity in organization of synaptic vesicles within individual synapses," said Dr. Ege Kavalali, assistant professor in the Center for Basic Neuroscience and of physiology at UT Southwestern and senior author on the study.

Neurotransmitters regulate many different aspects of mood, cognition and behavior, such as emotional state, reactions to stress, pain, and the physical drives of sleep, appetite and sexuality.

A better understanding of such fundamental mechanisms of neurotransmitter release will aid researchers in their investigations of psychiatric disorders and neurological disorder
'"/>

Source:UT Southwestern


Page: 1 2

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. U of M researcher examines newly emerging deadly disease
3. NYU researchers simulate molecular biological clock
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. Vital step in cellular migration described by UCSD medical researchers
6. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
7. UCSD researchers maintain stem cells without contaminated animal feeder layers
8. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
9. New protein discovered by Hebrew University researchers
10. First real-time view of developing neurons reveals surprises, say Stanford researchers
11. New research indicates a troubled greenhouse is brewing
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New research questions basic tenet neuron function

(Date:9/18/2014)... GSA Bulletin study uses tree rings to ... Chaco Wash in northern New Mexico, USA. By determining ... willow, investigators were able to precisely date arroyo sedimentary ... this data with aerial imagery, LiDAR, longitudinal profiles, and ... , Arroyos are deep, oversized channels that have vertical ...
(Date:9/18/2014)... research into the Crimean-Congo hemorrhagic fever virus (CCHFV), a ... humans similar to that caused by Ebolavirus, has identified ... has the potential to lead to novel targets for ... research, reported in a paper published today in the ... at the Texas Biomedical Research Institute and their colleagues, ...
(Date:9/18/2014)... "frequent flyers" program, fruit flies surely would be eligible ... increasing numbers of fruit fly research studies. One fruit ... and another is scheduled launch to the station Sept. ... December. , Fruit flies are biomedical research models studied ... organisms can reveal the basis for health and disease ...
Breaking Biology News(10 mins):Tree rings and arroyos 2Tree rings and arroyos 3Tree rings and arroyos 4Tree rings and arroyos 5Tree rings and arroyos 6Tree rings and arroyos 7Research milestone in CCHF virus could help identify new treatments 2Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4
... cases of 2009 H1N1 influenza, the virus can damage cells ... the 1918 and 1957 influenza pandemics, report researchers from the ... Office of Chief Medical Examiner. The scientists reviewed autopsy reports, ... died of 2009 H1N1 influenza infection between May 15 and ...
... Royal Swedish Academy of Sciences will collaborate to publish AMBIO ... AMBIO was founded in 1972, the year of the ... journal addresses the scientific, social, economic and cultural factors that influence ... Springer will be published in February 2010. AMBIO ...
... salmon species will have its genome fully sequenced, ... agencies and industry from Canada, Chile and Norway. ... Economic Development Agency, InnovaChile, Norwegian Research Council, Norwegian ... the International Cooperation to Sequence the Atlantic Salmon ...
Cached Biology News:New York autopsies show 2009 H1N1 influenza virus damages entire airway 2New York autopsies show 2009 H1N1 influenza virus damages entire airway 3Springer signs co-publishing agreement with the Royal Swedish Academy of Sciences 2Genome BC collaborates with Chile and Norway to sequence salmon genome 2
(Date:9/19/2014)... -- The new , Healthcare and Life Sciences ... on PharmaBoardroom.com for free download , looks ... Spanish economy in 2009, and the austerity measures that followed, ... in times of trouble. "Despite the crisis, ... market, and the general conditions to invest are favorable to ...
(Date:9/18/2014)... -- DeepResearchReports.com adds "2014 Deep Research Report on ... Deep Research Report on Global and China Sodium ... Photo - http://photos.prnewswire.com/prnh/20140918/147058 ... China Acetic Acid Industry" is a professional and ... and Global Acetic Acid Market. The report ...
(Date:9/18/2014)... Station, Texas (PRWEB) September 18, 2014 ... System Chancellor John Sharp, Texas A&M Health Science ... the U.S. Department of Health and Human Services ... today dedicated a national pandemic influenza vaccine manufacturing ... serve as an anchor for the Texas A&M ...
(Date:9/18/2014)... 18, 2014 Research and Markets ... Albumin Industry Report 2014" report to their offering. ... 2014 is a professional and in-depth study on the ... The report provides a basic overview of the ... The human albumin market analysis is provided for the ...
Breaking Biology Technology:PharmaBoardroom Releases New Spain Pharmaceuticals Report 2PharmaBoardroom Releases New Spain Pharmaceuticals Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 2Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 3Acetic Acid Market & Sodium Stannate Industry (China, Global) Research Report 4Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4Global Human Albumin Industry Report 2014 2Global Human Albumin Industry Report 2014 3
... MADISON - Tired of high gas costs and poor ... group of engineering students at the University of Wisconsin-Madison ... the cleanest and most fuel-efficient SUVs in North America. ... could one day be incorporated into mass-production hybrid SUVs. ...
... Doyle began turning up the heat on Republicans on ... had already turned the tables on him regarding problematic state ... subject of a state audit, recently were placed at the ... Kanavas , R-Brookfield, who has worked with the Governor on ...
... you judged Milwaukee by the economic indicators alone, you ... the dusty, bypassed town in the hit animated movie ... Hollywood ending, maybe theres a more prosperous, real-life road ... so, because without a healthy Milwaukee, most of Wisconsin ...
Cached Biology Technology:UW-Madison hybrid-vehicle team places second nationally 2GOP lawmaker faults Doyle for IT problems 2GOP lawmaker faults Doyle for IT problems 3It's an economic fact: As Milwaukee goes, so goes Wisconsin 2It's an economic fact: As Milwaukee goes, so goes Wisconsin 3
... siRNA Tracker Intracellular Localization Kit provides a ... deliver siRNA, of your design, in an ... tracking experiments. Subcellular localization and functional inhibition ... following introduction of the labeled siRNA into ...
... 60kDa (A) and 36kDa (C) subunits ... 7.5, 500mM NaCl, 60mM 2-mercaptoethanol, 1mM ... DTT, and 0.1mg/ml serum albumin Properites: ... proteins. Purification: DEAE chromatography, aminohexyl-agarose and ...
... Label IT siRNA Tracker Intracellular Localization Kit ... label and deliver siRNA, of your design, ... in vitro tracking experiments. Subcellular localization and ... be monitored following introduction of the labeled ...
... The Label IT siRNA Tracker Intracellular ... provides a straight forward approach to ... your design, in an efficient yet ... experiments. Subcellular localization and functional inhibition ...
Biology Products: