Navigation Links
New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease

/p>

"With no known cure, treatment options for Alport syndrome are limited to kidney transplantation or lifelong dialysis," he adds. "Our lab set out to determine if bone marrow-derived stem cell therapy might provide another treatment option."

Using a mouse model of the disease, in which COL4A3 ?one of the three type IV collagen genes that is mutated in Alport patients -- had been removed, the researchers transplanted allogenic bone marrow into the knockout mouse.

According to Kalluri, within a period of about four weeks, the investigators found that approximately 10 percent of the transplanted cells had incorporated into the damaged regions of the kidney glomeruli in the knockout mouse, emerging as healthy renal cells (podocytes and mesangial cells). This led to clear improvement in the animal's kidney function and repair of the glomerular architecture defects.

"These results offer a possible therapeutic opportunity for both children and adults with Alport syndrome," he says. In addition, the new findings demonstrate that bone-marrow-derived stem cells can be used to repair extracellular/basement membrane defects, and according to Kalluri, the researchers' next step will be to see if the use of embryonic stem cells and circulating adult stem cells will achieve the same function.

"This new evidence offers hope that this is a treatment strategy that can be explored for other diseases that result from extracellular matrix defects," he notes.

Study coauthors include BIDMC researchers Hikaru Sugimoto, MD, PhD, Thomas Mundel, MD, PhD, Malin Sund, MD, PhD, and Liang Xie, PhD, and Dominic Cosgrove of Boystown National Research Hospital, Omaha, Nebraska.


'"/>

Source:Beth Israel Deaconess Medical Center


Page: 1 2

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. U of M researcher examines newly emerging deadly disease
3. NYU researchers simulate molecular biological clock
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. New research questions basic tenet of neuron function
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:
(Date:7/29/2014)... wildfires that have been plaguing the Northern Territories in ... Great Lakes in the U.S. continue on. NASA,s ... Resolution Imaging Spectroradiometer, MODIS, instrument on July 26, 2014. ... outlined in red. Copious amount of smoke are drifting ... havoc for residents of Yellowknife. Fire has caused ...
(Date:7/29/2014)... University of Maryland Schools of Dentistry (UM SOD) ... they have received a five-year $10.7 million grant ... Infectious Diseases (NIAID) of the National Institutes of ... of sexually-transmitted diseases (STDs). The grant, which renews ... represents a new direction for the research by ...
(Date:7/29/2014)... to go and almost 2500 registered participants, the final ... The event, a joint venture between the Federation of ... for Biochemistry and Molecular Biology (SFBBM), will take place ... the Palais des Congrs in Paris, France. , The ... life sciences in Europe this year. It features more ...
Breaking Biology News(10 mins):University of Maryland Schools of Dentistry and Medicine receive NIH grant 2University of Maryland Schools of Dentistry and Medicine receive NIH grant 3University of Maryland Schools of Dentistry and Medicine receive NIH grant 4Counting down to FEBS-EMBO 2014 in Paris, France 2
... as it has become known, began on March 11, ... recorded. Following the quake, a 40 to 50-foot tsunami ... estimated 20,000 missing or dead. The massive wave also ... plant. , The release of radioactivity from Fukushimaboth as ...
... may be the 21st century, but nearly half the ... or primitive stoves that burn wood, animal dung, charcoal ... ACS journal Environmental Science & Technology describes ... the obstacles that remain. Susan C. Anenberg ...
... its detection when mixed into meatballs and other food and ... is food for a thoughtful installment of the popular Newscripts ... News . C&EN is the weekly newsmagazine of the American ... Tullo, C&EN senior editor, uses the story to look behind ...
Cached Biology News:Meeting: 'Experts Convene to Examine Impacts of Fukushima on the Ocean' 2
(Date:7/29/2014)... a number of significant technological challenges in their ... originally created for the James Webb Space Telescope. ... Moseley, a scientist at NASA,s Goddard Space Flight ... actuated microshutter arrays that is, those activated ... functional as the current technology,s magnetically activated arrays. ...
(Date:7/29/2014)... HOUSTON (July 29, 2014) Tough, ultralight foam ... and shape through a chemical process invented at Rice ... "GO-0.5BN" looks like a nanoscale building, with floors and ... a pair of two-dimensional materials: floors and walls of ... boron nitride platelets. , The researchers say the ...
(Date:7/29/2014)... 29, 2014 According to the ... Imaging), Analytics (Image Analysis Software), Delivery Modes (Web Based/Cloud ... & Trends to 2018", published by MarketsandMarkets, analyzes and ... such as North America , ... and the Rest of the World (RoW). ...
(Date:7/29/2014)... HILLS, Calif. , July 29, 2014 /PRNewswire/ ... specializing in personalized medicine, treatment of infectious diseases ... strategies of prognosis and prevention of pathologies like ... of August 1, 2014, ImmunoClin Corporation will complete ... Washington, D.C. , a key ...
Breaking Biology Technology:Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Tough foam from tiny sheets 2Digital Pathology Market worth $437 Million by 2018 2Digital Pathology Market worth $437 Million by 2018 3ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 2ImmunoClin Corporation (IMCL) Relocates Corporate Headquarters to Washington, DC 3
... will discuss the fourth quarter and year end,financial results for the fiscal year ended June ... 30, 2008 at 11:15 a.m. ET., Conference Call and Webcast Access Information, ... Call - Live ... 11:15 a.m. ET Domestic Dial-In Number ...
... introduced for the first time in the U.S. at the 16th annual ... on Oct. 2-4. , ... HOUSTON (Business Wire EON) September 30, ... assist device (VAD) that benefited from years of hands-on leadership and support ...
... 30 Verenium,Corporation (Nasdaq: VRNM ), a ... high-performance specialty enzymes, announced today,that Janet Roemer, Executive ... present at the upcoming William Blair & Company ... to begin,at 10:40 a.m. ET on Tuesday, October ...
Cached Biology Technology:Palatin Technologies, Inc. Revised Call-In Number for Teleconference and Webcast to be held on September 30, 2008 2 The Modern DeBakey VAD™ To Be Introduced For the First Time in the U.S. : HeartAssist 5™ Pediatric VAD Features Industry Exclusive Direct Blood Flow Measurement System 2 The Modern DeBakey VAD™ To Be Introduced For the First Time in the U.S. : HeartAssist 5™ Pediatric VAD Features Industry Exclusive Direct Blood Flow Measurement System 3Verenium Corporation to Present at the William Blair & Company 2008 Small-Cap Growth Stock Conference 2Verenium Corporation to Present at the William Blair & Company 2008 Small-Cap Growth Stock Conference 3
Direct ELISA Assay Diluent - EDTA, 10 L...
... Turn routine agarose gel electrophoresis into ... 96 system. This bufferless, pre-cast system is ... preparations, restriction digests, and more. Fully automated, ... the E-Gel 96 system makes your high-throughput ...
SpectroQuest single beam 4nm UV/Vis spectrophotometer; stand-alone unit; large angled LCD screen; large sample compartment...
... Cloning Kit, 40 reactions. Optimized for ... all PCR products with blunt or ... by offering consistently better signal-to-noise ratios ... positive clones.Amplicons generated by proof-reading thermostable ...
Biology Products: