Navigation Links
New research demonstrates bone-marrow derived stem cells can reverse genetic kidney disease

The discovery that bone-marrow derived stem cells can regenerate damaged renal cells in an animal model of Alport syndrome provides a potential new strategy for managing this inherited kidney disease and offers the first example of how stem cells may be useful in repairing basement membrane matrix defects and restoring organ function.

Led by researchers at Beth Israel Deaconess Medical Center (BIDMC), the findings are described in the Proceedings of the National Academy of Sciences (PNAS), which appears on-line the week of April 24, 2006.

Symptoms of Alport syndrome, the second most common genetic cause of kidney failure, usually appear in children, affecting the kidneys' filtration system and typically leading to end-stage renal disease in the patient's teens, 20s or 30s. The disease additionally causes deafness in some patients.

"This is one of 31 human diseases that occur because of genetic defects in the body's extracellular matrix and basement membrane proteins, " explains the study's senior author Raghu Kalluri, PhD, chief of the division of matrix biology at BIDMC and associate professor of medicine at Harvard Medical School.

Present throughout the body, the extracellular matrix (ECM) is made of collagens, proteogylcans, noncollagenous glycoproteins and in some tissues, elastin fibers. The ECM serves a unique role by constructing a "scaffold" for cells, thereby maintaining the structural integrity of many tissues.

"In normal kidneys, a specialized form of extracellular matrix known as the glomerular basement membrane [GBM], composed primarily of type IV collagen, is the key component of the blood filtration apparatus," says Kalluri.

However, in patients with Alport syndrome, mutations in three different type IV collagen genes cause structural damage to the GBM, leading to a breakdown of the organ's filtration system, and resulting in the seepage of blood and protein into the urine and eventual kidney failure.<
'"/>

Source:Beth Israel Deaconess Medical Center


Page: 1 2

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. U of M researcher examines newly emerging deadly disease
3. NYU researchers simulate molecular biological clock
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. New research questions basic tenet of neuron function
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:
(Date:7/9/2014)... In an era of increasing concern about the ... have identified a promising new pathway to disabling ... body. , The scientists showed how bacterial siderophore, ... supply sources to fan bacterial growth as ... counterassault against this infection process. Their findings appear ...
(Date:7/9/2014)... Adlie penguins shows that the population is 3.79 ... previously estimated. Adlie penguins have long been considered ... the effects of climate change and fishing in ... imagery, researchers from Stony Brook University and University ... permits regular monitoring of Adlie penguins across their ...
(Date:7/9/2014)... laboratory testing, countless measurement results accrue. To completely ... extremely time consuming. In fact, researchers in the ... managing data, according to an online survey of ... the Fraunhofer Institute for Applied Information Technology FIT ... that they have no centralized or structured approach ...
Breaking Biology News(10 mins):Bacteria hijack plentiful iron supply source to flourish 2New study finds that Ad&#233;lie penguin population is on the rise 2New study finds that Ad&#233;lie penguin population is on the rise 3Managing the data jungle 2Managing the data jungle 3
... to new research by a University of Exeter biologist. ... of beetles, moths and crickets, produce unusually large ejaculates, ... of their body weight. The study shows that dehydrated ... of the water in the seminal fluid. Dr ...
... in the September 2007 issue of the Journal ... ARTICLE HIGHLIGHTS Renal transplant recipients genetic ... chemicals New anti-inflammatory compound discovered Thematic Review: Understanding how ... Renal transplant recipients genetic makeup does not negatively impact ...
... University of Pennsylvania researchers have designed a nanoscale ... react to external forces. By combining ... independent, nanoscale sensors, the study showed that cells ... biological relationship between cells and their environment. The ...
Cached Biology News:Sex is thirst-quenching for female beetles 2Story ideas from the Journal of Lipid Research 2Story ideas from the Journal of Lipid Research 3Story ideas from the Journal of Lipid Research 4Story ideas from the Journal of Lipid Research 5Bioengineers at University of Pennsylvania devise nanoscale system to measure cellular forces 2
(Date:1/15/2014)... 2014 2013 was a banner year ... Technologies®. They saw continued independent research led by the ... awarded a $1 million grant from the Susanne Marcus ... Behavior” a peer reviewed journal, Amy Grant highlighted Brainwave ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Carahsoft and ... Thursday, January 23, 2014 at 2pm EST (11am PST), ... The topic focuses on how technology can turn raw, ... decisions for government agencies. The online webinar will last ...
(Date:1/14/2014)... , Jan. 14, 2014 The largest international ... medicinal plants and therapeutic derivatives thereof has endorsed ... and researchers about the challenges of adulterated herb ... ) The Society for Medicinal ...
(Date:1/14/2014)... Global Record Systems, LLC, (GRS), ... solutions for patients, physicians, the biopharmaceutical industry, regulators, ... the signing of a three-year Research Collaboration Agreement ... (FDA). This initiative is designed to generate ...
Breaking Biology Technology:Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Webcast - Natural Language Processing: Converting Raw Data into Actionable Knowledge – Hosted by Carahsoft and CDS Federal Services 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 2World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 3World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 4World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 5World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 6World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 7World's Largest Group of Medicinal Plant Researchers Endorses ABC-AHP-NCNPR Botanical Adulterants Program 8Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2
... , , , , , , For purification of endotoxin-free ... Features and benefits , , ... 10 mg plasmid DNA , Greater than 90% recovery of plasmid DNA ... , , , ...
... , , , Frank Narz, Silke ... , , Primary ... of neuronal cells by delivery of either siRNA or plasmid DNA challenging , ... of endogenous genes in primary rat hippocampal and cortical neurons using , ...
... , , , , , ... Corinna Kppers, Gaby Schulte, Silke Zobel, and Dirk Lffert , ... , Microsatellites highly polymorphic DNA markers comprised ... and distributed throughout the genome , are a ...
Cached Biology Technology:EndoFree Plasmid Kits 2EndoFree Plasmid Kits 3EndoFree Plasmid Kits 4Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 2Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 3Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 4Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 5Efficient DNA transfection of primary CNS neurons using TransMessenger , Transfection Reagent 6Fully automated DNA purification and efficient multiplex PCR for analysis , of microsatellite loci 2Fully automated DNA purification and efficient multiplex PCR for analysis , of microsatellite loci 3Fully automated DNA purification and efficient multiplex PCR for analysis , of microsatellite loci 4Fully automated DNA purification and efficient multiplex PCR for analysis , of microsatellite loci 5
Mouse monoclonal antibody raised against a full length recombinant GPT. NCBI Entrez Gene ID = GPT...
Mouse monoclonal antibody raised against a partial recombinant PDE2A. NCBI Entrez Gene ID = PDE2A...
... coli protein sample is a complex ... consistent pattern when used with ReadyPrep ... buffer. This sample can be used ... 2-D system and protocol before using ...
... Tecans new HydroFlex platform provides ... a range of 96-well format applications, ... and protein arrays, and vacuum filtration-to-waste, ... platforms outstanding on-line control features set ...
Biology Products: