Navigation Links
New research could help us deliver genes for new bone formation

UK scientists are working on new methods to regenerate cartilage and bone by delivering genes to stem cells within the body to instruct them to turn into bone cells. The research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), could lead to a new approach to tissue engineering. With the ageing populations of Western countries it holds the potential of significant benefits for patients needing joint replacement or similar treatments.

The new research will use tiny nanoscopic systems that cross the surface of a stem cell and then deliver the genes into that prompt the cell to turn into a bone cell.

Professor Richard Oreffo at the University of Southampton and Dr Martin Garnett and Professor Kevin Shakesheff at the University of Nottingham are developing scaffolds to act as a coating around the nanoscopic gene delivery systems. The scaffold controls the release of the gene delivery systems to generate the prolonged formation and development of bone tissue.

The research teams are using the scaffold technology to develop therapeutic applications. They are investigating the most efficient and effective combinations of genes and delivery scaffold to trigger the highly complex process of bone formation. The technique, if successful, could provide a new source of bone tissue for orthopaedic procedures.

Professor Richard Oreffo, who is leading the team at the University of Southampton, said, "The key to the process is careful selection of the right genes for the job, and then identifying the right scaffold delivery mechanism to deliver the genes to enough stem cells to initiate the bone formation process. This method of gene delivery could provide significant healthcare benefits as trauma, degenerative disease and bone loss with old age all lead to patients needing orthopaedic procedures that require new bone.

Professor Oreffo added "It is important that we explore the potential of new methods and biotechn
'"/>

Source:Biotechnology and Biological Sciences Research Council


Page: 1 2

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. U of M researcher examines newly emerging deadly disease
3. NYU researchers simulate molecular biological clock
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. New research questions basic tenet of neuron function
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New research could help deliver genes for new bone formation

(Date:5/20/2013)... popularly known as the lungs of the planet, inhales carbon ... the air to grow parts that eventually fall to the ... plentiful rainfall. , Until recently people believed much of ... ended up deep in the ocean. University of Washington research ... carbon dioxide though left open the question of how ...
(Date:5/20/2013)... University of Bristol and published online today in the ... how the brain and inner ear developed in dinosaurs. ... Sciences, together with Tom Hbner from the Niederschsische Landesmuseum ... year old dinosaurs. , The two palaeontologists studied different ... a very young (juvenile) individual of approximately three ...
(Date:5/19/2013)... the University of California, Davis have engineered a strain ... light. They report their findings today at the ... , "In this work, we used synthetic biology approaches ... dioxide and light energy for growth) cyanobacterial metabolism for ... McEwen, the lead researcher on the study. He ...
Breaking Biology News(10 mins):Amazon River exhales virtually all carbon taken up by rain forest 2Amazon River exhales virtually all carbon taken up by rain forest 3Fossil brain teaser 2
... even those caused by antibiotic-sensitive bacteria, resist treatment. This ... impossible to cure. A key cause of this ... Starved bacteria resist killing by nearly every type of ... What produces starvation-induced antibiotic resistance, and how ...
... flower petals shows evolution in action, and contradicts more that ... by a scientist from UC Santa Barbara and a research ... Society B this week. Columbine flowers, known as Aquilegia, ... lengths of their pollinators, including bees, hummingbirds, and hawkmoths. The ...
... Like a shadowy character just hidden from view, a ... called nitrogenase had long hindered scientists, ability to study ... of scientists led by Serena DeBeer, Cornell assistant professor ... curtain using powerful synchrotron spectroscopy and computational modeling to ...
Cached Biology News:What bacteria don't know can hurt them 2What bacteria don't know can hurt them 3Study of flower petals shows evolution at the cellular level 2In an enzyme critical for life, X-ray emission cracks mystery atom 2
(Date:5/21/2013)... Boston, MA (PRWEB) May 21, 2013 Possible ... parents. And so, according to a report from eagletribune.com posted ... for mold. In case the result is positive, My Cleaning ... without using harmful chemical ingredients. , It was said in ... re-infestation in the campus sparked after a first-grade ...
(Date:5/21/2013)... Clinovo's new “CDISC Standards: Theory and Application” ... June 11th, 2013. The TechTrainings are technical hands-on classes ... step in their professional career. The class will be ... online. , Taught by Sy Truong, President at Meta-Xceed ... Theory and Application” class will give an overview of ...
(Date:5/20/2013)... , May 20, 2013  MiMedx Group, Inc. (NASDAQ: ... marketer of patent protected regenerative biomaterials and bioimplants processed ... secured a revolving line of credit with Bank of ... secured by the Company,s accounts receivable and inventory, allows ... 1, 2014.  The facility will be used for general ...
(Date:5/20/2013)... Biomarkers and Clinigene International are set to unveil their ... 2013 AAPS/ National Biotechnology Conference May 20-22 ... Marina , San Diego, CA. ... company representatives at their collaborative seminar, "Biosimilarity, Immunogenicity and ... 1-2 p.m. in the conference,s Spinnaker Room. ...
Breaking Biology Technology:Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 2Possible Mold Re-infestation Gets Guilmette School Scheduled for Re-inspection, My Cleaning Products Offers Tip How to Kill Mold Safely If Inspection Turns Positive 3Clinovo Launches TechTrainings on CDISC Standards 2Pacific Biomarkers and Clinigene International To Announce Laboratory Solutions for Developers of Biosimilars at 2013 AAPS/ National Biotechnology Conference 2
... DVA ) today announced that it will present ... Thursday, September 20, 2007 at 4:15 p.m.,GMT. (Logo: ... go to http://www.ibb.ubs.com, click on the,Conferences icon ... webcast link,listed next to the relevant conference title. The ...
... iiBIG,s New Directions for Drug,Delivery: Emerging Modes, ... scheduled for October 29-30, 2007, at the ... cover developments in controlled release,technologies, nanobiomedicine, siRNa, ... and other novel applications for,oral/nasal/transdermal/injectable and other ...
... AUSTIN, Texas, Sept. 17 Luminex Corporation,(Nasdaq: LMNX ... Partners Fifth Annual Growth Conference to be held September,17-20, ... The investor presentation by Patrick J. Balthrop, president ... time; 2:00 p.m. Eastern,time on Tuesday, September 18, 2007. ...
Cached Biology Technology:Drs. John Patton of Nektar, Igor Gonda of Aradigm, Tomas Landh of Novo Nordisk, Chris Rhodes of Amylin to Speak at iiBIG's Plenary Panel in Vegas 2Drs. John Patton of Nektar, Igor Gonda of Aradigm, Tomas Landh of Novo Nordisk, Chris Rhodes of Amylin to Speak at iiBIG's Plenary Panel in Vegas 3Luminex Corporation to Present at ThinkEquity Partners Investor Conference 2
... ELISA Development kit contains the basic components ... to measure natural and recombinant canine Monocyte ... supernates and serum.1 Each kit contains sufficient ... 96-well plates, provided that the following conditions ...
Mouse monoclonal [LPL4A.1] to Plastin L ( Abpromise for all tested applications). SwissProtID: P13796...
Component of HyperMu™ Insertion Kit...
Recombinant Rhesus Macaque IFN-alpha...
Biology Products: