Navigation Links
New research could help us deliver genes for new bone formation

UK scientists are working on new methods to regenerate cartilage and bone by delivering genes to stem cells within the body to instruct them to turn into bone cells. The research, funded by the Biotechnology and Biological Sciences Research Council (BBSRC), could lead to a new approach to tissue engineering. With the ageing populations of Western countries it holds the potential of significant benefits for patients needing joint replacement or similar treatments.

The new research will use tiny nanoscopic systems that cross the surface of a stem cell and then deliver the genes into that prompt the cell to turn into a bone cell.

Professor Richard Oreffo at the University of Southampton and Dr Martin Garnett and Professor Kevin Shakesheff at the University of Nottingham are developing scaffolds to act as a coating around the nanoscopic gene delivery systems. The scaffold controls the release of the gene delivery systems to generate the prolonged formation and development of bone tissue.

The research teams are using the scaffold technology to develop therapeutic applications. They are investigating the most efficient and effective combinations of genes and delivery scaffold to trigger the highly complex process of bone formation. The technique, if successful, could provide a new source of bone tissue for orthopaedic procedures.

Professor Richard Oreffo, who is leading the team at the University of Southampton, said, "The key to the process is careful selection of the right genes for the job, and then identifying the right scaffold delivery mechanism to deliver the genes to enough stem cells to initiate the bone formation process. This method of gene delivery could provide significant healthcare benefits as trauma, degenerative disease and bone loss with old age all lead to patients needing orthopaedic procedures that require new bone.

Professor Oreffo added "It is important that we explore the potential of new methods and biotechn ologies to help meet the healthcare needs of an ageing population. Although research such as this is currently a number of years from being available to patients it is important that fundamental research is carried out so we can develop the knowledge that can lead to clinical applications."


Source:Biotechnology and Biological Sciences Research Council

Related biology news :

1. Columbia research lifts major hurdle to gene therapy for cancer
2. U of M researcher examines newly emerging deadly disease
3. NYU researchers simulate molecular biological clock
4. First atlas of key brain genes could speed research on cancer, neurological diseases
5. New research questions basic tenet of neuron function
6. Vital step in cellular migration described by UCSD medical researchers
7. ASU researchers finds novel chemistry at work to provide parrots vibrant red colors
8. UCSD researchers maintain stem cells without contaminated animal feeder layers
9. Why do insects stop breathing? To avoid damage from too much oxygen, say researchers
10. New protein discovered by Hebrew University researchers
11. First real-time view of developing neurons reveals surprises, say Stanford researchers
Post Your Comments:

(Date:11/12/2015)...  Arxspan has entered into an agreement with ... use of its ArxLab cloud-based suite of biological ... will support the institute,s efforts to electronically manage ... internally and with external collaborators. The ArxLab suite ... Institute,s electronic laboratory notebook, compound and assay registration, ...
(Date:11/10/2015)... YORK , Nov. 10, 2015 ... to behavioral biometrics that helps to identify and ... fraud. Signature is considered as the secure and ... the identification of a particular individual because each ... more accurate results especially when dynamic signature of ...
(Date:11/2/2015)... 2015  SRI International has been awarded a contract ... services to the National Cancer Institute (NCI) PREVENT Cancer ... expertise, modern testing and support facilities, and analytical instrumentation ... toxicology studies to evaluate potential cancer prevention drugs. ... Cancer Drug Development Program is an NCI-supported pipeline to ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... Calif. , Nov. 24, 2015 Cepheid ... will be speaking at the following conference, and invited ... New York, NY      Tuesday, December 1, 2015 ... New York, NY      Tuesday, December 1, 2015 ... Jaffray Healthcare Conference, New York, NY ...
(Date:11/24/2015)... - iCo Therapeutics ("iCo" or "the Company") (TSX-V: ICO) ... quarter ended September 30, 2015. Amounts, unless specified ... under International Financial Reporting Standards ("IFRS"). ... Andrew Rae , President & CEO of iCo ... value enriching for this clinical program, but also ...
(Date:11/24/2015)... ... November 24, 2015 , ... ... the year and one of the premier annual events for pharmaceutical manufacturing: 2015 ... 8–11 November 2015, where ISPE hosted the largest number of attendees in more ...
(Date:11/24/2015)... , Nov. 24, 2015  Clintrax Global, Inc., a worldwide ... Carolina , today announced that the company has set a ... a 391% quarter on quarter growth posted for Q3 of 2014 ... and Mexico , with the establishment of ... December 2015. --> United Kingdom and ...
Breaking Biology Technology: