"We are definitely optimistic that this time there will be some movement, that this time there will be not just talk about an HIV strategy for the AU but how to tackle an action-oriented plan," Oxfam spokeswoman Shehnilla Mohamed said.
"Governments are learning that fighting AIDS is not just a health issue but a development issue," she said.
"Now they have to deliver on the existing protocols and develop a serious and practical strategy."
Mozambique is the only country that has, thus far, committed to allocating 15 per cent of its gross domestic product to healthcare in the four years since the goal was stated during the founding of the pan-African body.
The rest of the 52 countries included in the African Union spend less than 10 per cent of their annual revenues on health, anti-AIDS and anti-HIV efforts included.
Controversial drug trials, battles over patents and the fate of millions of orphans are also likely to be discussed at a summit session devoted to the fight against AIDS on the world's poorest continent, home to nearly two-thirds of the 39.4 million people worldwide infected with HIV or AIDS.
The World Health Organisation (WHO) says just 310,000 people in Africa were being treated with a cocktail of antiretroviral (ARV) drugs that inhibit the progression of their disease, which has no known cure.
But demand for free drugs vastly outstrips their supply, the cost of the drugs - at some $US600 annually for the rest of a patient's life, an impossible dream on the continent.
Generic versions of the drugs have been priced at roughly $US300 a year, the costs for which the WHO hopes will be offset by national resources, international agencies and private or government donations.