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New protein vital for immune response is found in surprise location

s not known. Researchers have been trying to identify and characterize the proteins involved in an effort to better understand the nature of viral infection and how to combat it.

Dr. Chen said he and his group believe MAVS is among a group of molecules that play a role in activating other proteins - including IRF-3 and NF-kappaB - that prod the cell into making interferon. He also said there is evidence that MAVS binds with RIG-I, but more experiments are needed to determine just how MAVS functions within the cell.

Other UT Southwestern researchers involved in the studies were lead authors Rashu Seth, a graduate student research assistant, and Dr. Lijun Sun, a postdoctoral researcher in molecular biology, and Chee-Kwee Ea, a medical student research assistant.


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Source:UT Southwestern Medical Center


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