Navigation Links
New protein vital for immune response is found in surprise location

A newly discovered protein not only is vital to the immune system's ability to fight off viral infections but also has been found in an unexpected location within the cell, causing researchers to rethink previous notions about the workings of the human immune system.

Researchers at UT Southwestern Medical Center said their findings may lead to new therapies aimed at preventing and treating viral diseases such as the flu, hepatitis, West Nile virus and SARS. The study is available online and will appear in the Sept. 9 issue of the journal Cell.

Working with cultured cells, researchers found that the protein, made by a gene they discovered and named MAVS, is located in an unexpected place within the cell ?in the membrane of an organelle called the mitochondrion, which until now was best known for generating energy required for daily life.

"This is the first mitochondrial protein known to be involved in immune defense against any microbial infection," said Dr. Zhijian "James" Chen, associate professor of molecular biology at UT Southwestern and the study's senior author. "This discovery puts mitochondria on the map in terms of immunity, and it opens up a new avenue of research in immunology."

The researchers modified normal cells so that the cells could not produce the MAVS protein, which is short for Mitochondrial Anti-Viral Signaling protein. Without MAVS, the cells were highly vulnerable to infection with two common viruses in a class called RNA viruses Other RNA viruses include hepatitis C, West Nile, SARS and the flu viruses.

Cells altered to produce an overabundance of MAVS were protected from dying from viral infection.

"These results raise the possibility that variations in the expression levels of MAVS may endow different individuals with varying ability to fight off viral diseases," said Dr. Chen, who also is an investigator with the Howard Hughes Medical Institute. "Viruses have evolved along with humans and ha
'"/>

Source:UT Southwestern Medical Center


Page: 1 2 3

Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New protein vital for immune response found surprise location

(Date:8/27/2014)... have shown that excessive iron is closely ... Previous studies from Chunyan Guo and co-workers ... shown that baicalin prevented iron accumulation after ... 1 expression, and increased ferroportin 1 expression ... disease rats. However, the relationship between iron ...
(Date:8/27/2014)... hours ago the Happy Camp Complex of fires had ... July complex had consumed 35,530 as of eight hours ... the Happy Camp Ranger District of the Klamath National ... August 11, 2014. All but three of those fires ... list of contained fires and their size at containment: ...
(Date:8/27/2014)... have found that century-old museum specimens hold clues to how ... can weaken and kill trees and the news is ... increase on oak and maple trees in warmer urban areas, ... with global warming," says Dr. Elsa Youngsteadt, a research associate ... the work. , "More scale insects would be a problem, ...
Breaking Biology News(10 mins):Happy Camp and July Fire Complexes in California 2Museum specimens, modern cities show how an insect pest will respond to climate change 2
... flu continues its global spread, researchers from the Children,s ... why influenza is more severe in some people than ... online in the Journal of Leukocyte Biology ... virus can actually paralyze the immune systems of otherwise ...
... processes are carried out by molecular machines that consist ... the heart of life science research, but they are ... low to extract them directly from cells and generating ... A new technology to produce multiprotein complexes, developed by ...
... today launched a research partnership to find biomarkers for ... smoked. The research studies are designed to create a ... to develop a test to detect early-stage lung cancer ... nonprofit organization that funds research in early cancer detection, ...
Cached Biology News:Scientists learn why the flu may turn deadly 2New early detection studies of lung cancer in non-smokers launched today 2New early detection studies of lung cancer in non-smokers launched today 3
(Date:8/27/2014)... August 27, 2014 According to the ... to reshape the look and feel of markets for ... for higher-quality ingredients will push for more branded, science-backed ... have experienced strong market growth in the last decade ... their food and cosmetics to fit a more ‘wellness’ ...
(Date:8/26/2014)... the thinnest-possible semiconductor, a new class of nanoscale ... , The University of Washington researchers have demonstrated ... be connected in an atomically seamless fashion known ... basis for next-generation flexible and transparent computing, better ... "Heterojunctions are fundamental elements of electronic and photonic ...
(Date:8/26/2014)... 2014 The 20 ambassadors representing the ... community issued the following statement on Facebook today regarding ... driving new funding specifically for ALS research: , “Who ... some ice would raise all this awareness and funding ... and on behalf of the entire ALS community, would ...
(Date:8/26/2014)... Aug. 26, 2014 An analysis by Replikins, ... all Dengue virus strains in Pubmed, has revealed extensive ... 1944. This conservation and sharing of specific Replikin gene ... Blocker-Vaccine™ candidate, as it did for the H5N1 influenza ... which have been found to be effective (1,2). ...
Breaking Biology Technology:Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 2Daring to be Different Raw Materials & Ingredient Supply Shortage Fuels Vital Force™ Technology New Ingredient Enhancements 3Scientists craft atomically seamless, thinnest-possible semiconductor junctions 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 2ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 3ALS TDI’s Young Faces of ALS Ambassadors Thank You for Accepting the Ice Bucket Challenge to End ALS 4
... MOUNTAIN VIEW, Calif., Feb. 17 Frost & Sullivan, ... is,regaining its strength, thanks in part to an unprecedented ... additional stimulus packages from,foreign governments. , ... "President Obama,s stimulus package is clearly serving ...
... Warwick have found that tiny nanoparticles could be twice ... non mixing liquids than previously believed. This opens ... of nanoparticles in living cells, polymer composites, and ... working on ways of further artificially enhancing this new ...
... LLC, a wholly owned subsidiary of The Dow Chemical ... Rice Research Institute (CNRRI) of Hangzhou,China, announced today that ... strengths of Dow AgroSciences, platform of traits and technologies,with ... "We look forward to working with CNRRI to introduce ...
Cached Biology Technology:Frost & Sullivan Forecasts Early Rebound: Strong Growth Ahead for Global Economy 2Nanoparticles double their chances of getting into sticky situations 2Dow AgroSciences, China National Rice Research Institute Announce Collaboration on Rice Research 2
Mouse Amphiregulin MAb (Clone 206220)...
Anti-Digoxigenin-AP, Fab fragments; from sheep...
The antibody recognizes the peptide sequence ESESQGPK (aa 441-448) of human class III beta-tubulin specific for neurones....
Unique enzyme blend containing Taq and Pwo DNA Polymerase and another thermostable enzyme. The Expand 20 kbPLUS PCR System also includes an optimized reaction buffer, MgCl2 solution, and a human cont...
Biology Products: