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New protein discovered by Hebrew University researchers

d thus enhance the effectiveness of chemotherapy. This selective penetration is based on the fact that the blood vessels which feed tumors are considerably more porous than those reaching healthy cells. Therefore, the units of SP-1 carrying the drug would invade only the tumor-feeding blood vessels and not normal ones. More recently, the three-dimensional structure of the protein was deciphered by x-ray crystallography. The research on this was published in the Journal of Biological Chemistry issue of December 2004, authored by graduate student Orna Dgany, Prof. Altman and Prof. Shoseyov, in cooperation with Dr. Orna Almog of Ben-Gurion University of the Negev and Dr. Sharon Wolf of the Weizmann Institute of Science and other researchers. Prof. Altman and Prof. Shoseyov are the scientific founders of the biotech start-up company Fulcrum SP Ltd. that is developing the SP-1 protein for cancer drug delivery and other applications.
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Source:Hebrew University of Jerusalem


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