Navigation Links
New protein discovered by Hebrew University researchers

Researchers at the Hebrew University of Jerusalem have succeeded in discovering and isolating a new protein from the poplar tree with special structural and qualitative characteristics that could have consequences for development of future nanocapsules for drug delivery to cancer cells. In addition to being obtained from plant tissue, the protein can now also be produced in large quantities as a recombinant protein in bacteria, making it highly available for medicinal or other applications. Called SP-1, the protein has a nanometric, "bagel-shaped," circular form and is extremely stable. It has been found to be capable of surviving contact with enzymes that break down proteins or exposure to extreme conditions such as boiling, excessive acidity, salinity, organic solvents or detergent solutions.

The research was conducted at the Hebrew University's Faculty of Agricultural, Food and Environmental Quality Sciences in Rehovot by Prof. Arie Altman, head of the faculty's Institute of Plant Sciences and Genetics in Agriculture, and Prof. Oded Shoseyov, with the participation of Dr. Wangxia Wang and Dr. Dan Pelah and the scientists of Fulcrum SP Ltd.: Dr. Amnon Wolf, Dr. Ira Marton and Dr. Yonatan Puny. According to Profs. Altman and Shoseyov, the SP-1 protein serves to assist in creating a properly folded and functioning structure of other proteins within the plant's cells. The SP-1 also has the ability to assemble itself into a structure composed of 12 identical units, making it exceptionally resistant to extreme conditions. These qualities are rarely found among proteins and make the SP-1 a promising candidate for a multiplicity of uses in developing medicinal applications in the rapidly growing field of nanobiotechnology. SP-1 nanocapsules will be capable of delivering cell-destroying drugs specifically to certain types of solid cancer tumors. The protein's tiny structure enables this carrier to penetrate specifically into tumors without harming healthy tissue an d thus enhance the effectiveness of chemotherapy. This selective penetration is based on the fact that the blood vessels which feed tumors are considerably more porous than those reaching healthy cells. Therefore, the units of SP-1 carrying the drug would invade only the tumor-feeding blood vessels and not normal ones. More recently, the three-dimensional structure of the protein was deciphered by x-ray crystallography. The research on this was published in the Journal of Biological Chemistry issue of December 2004, authored by graduate student Orna Dgany, Prof. Altman and Prof. Shoseyov, in cooperation with Dr. Orna Almog of Ben-Gurion University of the Negev and Dr. Sharon Wolf of the Weizmann Institute of Science and other researchers. Prof. Altman and Prof. Shoseyov are the scientific founders of the biotech start-up company Fulcrum SP Ltd. that is developing the SP-1 protein for cancer drug delivery and other applications.
'"/>

Source:Hebrew University of Jerusalem


Related biology news :

1. New, automated tool successfully classifies and relates proteins in unprecedented way
2. New binding target for oncogenic viral protein
3. Controversial drug shown to act on brain protein to cut alcohol use
4. Timing is everything: First step in protein building revealed
5. UWs Rosetta software to unlock secrets of many human proteins
6. Researchers find how protein allows insects to detect and respond to pheromones
7. Signaling protein builds bigger, better bones in mice
8. Ancient olfaction protein is shared by many bugs, offering new pest control target
9. Automatic extraction of gene/protein biological functions from biomedical text
10. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
11. Scientists develop new color-coded test for protein folding

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/19/2016)... April 20, 2016 The new ... a compact web-based "all-in-one" system solution for all door ... reader or the door interface with integration authorization management ... control systems. The minimal dimensions of the access control ... the building installations offer considerable freedom of design with ...
(Date:4/13/2016)... physicians supporting Medicaid patients in Central Florida ... telehealth thanks to a new partnership with higi.   ... can routinely track key health measurements, such as blood ... they opt in, share them with IMPOWER clinicians through ... location at no cost. By leveraging this data, IMPOWER ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... CLEVELAND , June 27, 2016  Global ... average 4.6 percent through 2020 to $7.2 billion.  ... (food and beverages, cleaning products, biofuel production, animal ... and biotechnology, diagnostics, and biocatalysts). Food and beverages ... gains driven by increasing consumption of products containing ...
(Date:6/27/2016)... ... June 27, 2016 , ... Parallel 6 , the leading software as ... Clinical Reach Virtual Patient Encounter CONSULT module which enables both audio and video ... trial team. , Using the CONSULT module, patients and physicians can schedule a face ...
(Date:6/27/2016)... --  Ginkgo Bioworks , a leading organism design ... awarded as one of the World Economic Forum,s ... innovative companies. Ginkgo Bioworks is engineering biology to ... in the nutrition, health and consumer goods sectors. ... including Fortune 500 companies to design microbes for ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
Breaking Biology Technology: