Navigation Links
New possibilities for flu antiviral and vaccine research emerge from 'Spanish flu' virus

es that made the 1918 virus so exceptionally deadly. We wanted to identify the specific genes responsible for its virulence, with the hope of designing antivirals or other interventions that would work against virulent pandemic or epidemic influenza viruses," said Tumpey.

"Science is publishing this study because it provides information necessary for developing drugs and vaccines that could help prevent another global flu pandemic. We carefully considered the implications of publishing this research and concluded that the knowledge we're gaining to potentially protect public health far outweighs the risk of working with this virus," said Donald Kennedy, editor-in-chief of Science.

"We were comforted to learn that this also was the conclusion of Dr. Anthony Fauci of the U.S. National Institute of Allergy and Infectious Diseases, Dr. Julie Gerberding of the Centers for Disease Control and Prevention, and Dr. Amy Patterson of the Office of Biotechnology Activities within the Office of Science Policy at the U.S. National Institutes of Health. Dr. Patterson is the spokesperson for the National Science Advisory Board for Biodefense (NSABB), which provides guidance and advice on the implications for dual use research and publication," Kennedy said.

To make the virus, the researchers used an approach called "reverse genetics," which involves transferring gene sequences of viral RNA into bacteria and then inserting combinations of the genes -- often after manipulating them -- into cell lines, where they combine to form a virus.

For the Science study, Jeffery Taubenberger of the Armed Forces Institute of Pathology provided the coding sequences for the eight Spanish flu genes to Christopher Basler, Peter Palese, Adolfo Garcíˇ­Sastre and their colleagues at the Mount Sinai School of Medicine. They spliced these sequences together with noncoding DNA from a closely related virus, since this portion of the genome wasn't available for the Spanish flu
'"/>

Source:American Association for the Advancement of Science


Page: 1 2 3

Related biology news :

1. New possibilities to fight pests with biological means
2. Three-dimensional, miniature endoscope opens new diagnostic possibilities
3. Heart failure: Intervention possibilities from imaging programmed cell loss
4. The quest for an effective HIV vaccine presents new possibilities, challenges
5. Novel antiviral technology inhibits RSV infection in mice
6. Biota makes major antiviral discovery
7. The reason why antiviral therapy cant annihilate HIV infection, and what to do about it
8. Bird flu -- Call for antiviral drugs to be shared
9. Research advances quest for HIV-1 vaccine
10. A much-needed shot in the arm for HIV vaccine development
11. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
Post Your Comments:
(Date:9/1/2014)... CAMBRIDGE, Mass-- Conventional wisdom has long held that ... of coral reefs are passive organisms that ... substances, such as nutrients and oxygen. But now ... Science (WIS) in Israel have found that they ... sweep water into turbulent patterns that greatly enhance ...
(Date:9/1/2014)... AM EDT) It may be possible to train ... higher-calorie foods, according to new research by scientists at ... Aging (USDA HNRCA) at Tufts University and at Massachusetts ... Nutrition & Diabetes , a brain scan study in ... to reverse the addictive power of unhealthy food while ...
(Date:9/1/2014)... electron microscopy revealed the presence of tiny blob-like structures ... scientists still don,t know what they do even ... to be crucial to the life of a cell, ... treatment., In the Journal of Cell Biology , ... various backgrounds, from biophysics to cell biology, to focus ...
Breaking Biology News(10 mins):Nature's tiny engineers 2Nature's tiny engineers 3Training your brain to prefer healthy foods 2Scientists call for investigation of mysterious cloud-like collections in cells 2
... has named its awardee for this year,s Alan ... Brown University. Dunn,s work involves genome analyses ... He investigates the origins of biological complexity ... research holds clues about how complex multicellular organisms, ...
... This release is available in French . ... without exposing the healthy surrounding tissue to the medication,s toxic ... medical reality, thanks to the work of Professor Sylvain Martel, ... Known for being the world,s first researcher to have guided ...
... most controversial aspects in the sustainable management of golf courses. ... the practices relating to reclaimed water at one of the ... on the course receive 83% more water than they need. ... be justified from any perspective", Mara del Pino Palacios Daz, ...
Cached Biology News:Casey Dunn to receive NSF Waterman Award 2Casey Dunn to receive NSF Waterman Award 3World first -- Localized delivery of an anti-cancer drug by remote-controlled microcarriers 2Golf courses that reuse water irrigate too much 2Golf courses that reuse water irrigate too much 3
(Date:8/28/2014)... MA (PRWEB) August 28, 2014 “This kit ... test to screen from 0 to 150 ppb,” said Mark ... is a significant benefit to plant owners and USDA-GIPSA inspection ... and other commodities. Testing can take place in a matter ... only can the plant test the feed and grain before ...
(Date:8/28/2014)... in spintronics, an electronic which is not only ... on their spin and the spin-related magnetism. Spin-charge ... signals and vice versa. Recently, the research group ... Physics at Johannes Gutenberg University Mainz in collaboration ... has for the first time realised a new, ...
(Date:8/28/2014)... Willow Grove, PA (PRWEB) August 28, 2014 ... talent, and create a culture that will allow individuals ... that are becoming increasingly important for employers looking to ... life science industries are embracing this trend, as the ... the fabric of a company, which will have real ...
(Date:8/28/2014)... SunTrust Robinson Humphrey (STRH) today announced the ... research team in biotechnology and oilfield services.  ... demonstrates our commitment to providing our valued institutional ... decision making," said Biff Woodruff , Head ... significant investments in differentiated content at a time ...
Breaking Biology Technology:A new, tunable device for spintronics 2A new, tunable device for spintronics 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 2SunTrust Robinson Humphrey Expands Equity Research in Healthcare and Energy 3
... Emmanuel Labourier , Ambion, Inc , ... from the same sample Enrich for , ... , for assessing siRNA or miRNA expression and ... (siRNAs) and , microRNAs (miRNAs) have emerged as ...
... , High ... Only ethically sourced tissue is used , Custom RNA isolations from tissue ... Begins at the Source , Use ... that you are getting the highest , quality ...
... In Vitro Translation Kit , ... of protein than reticulocyte , lysate systems , ... biological activity than other E. coli , lysate systems ... researchers studying protein function and , ...
Cached Biology Technology:Isolate It All: siRNA miRNA , Total RNA Native Protein 2Isolate It All: siRNA miRNA , Total RNA Native Protein 3Isolate It All: siRNA miRNA , Total RNA Native Protein 4Isolate It All: siRNA miRNA , Total RNA Native Protein 5Isolate It All: siRNA miRNA , Total RNA Native Protein 6Isolate It All: siRNA miRNA , Total RNA Native Protein 7Isolate It All: siRNA miRNA , Total RNA Native Protein 8Isolate It All: siRNA miRNA , Total RNA Native Protein 9High Quality RNA Isolation Services 2Increase Protein Activity and Yield 2Increase Protein Activity and Yield 3
...
... contains the basic components required for the ... and recombinant canine Monocyte Chemotactic Protein 1 ... Each kit contains sufficient materials to run ... that the following conditions are met:2 ...
Mouse monoclonal [LPL4A.1] to Plastin L ( Abpromise for all tested applications). SwissProtID: P13796...
Component of HyperMu™ Insertion Kit...
Biology Products: