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New path from estrogen to survival in breast cancer cells described

vival of breast cancer cells by silencing BCA3, through eliminating its hold on NFkB transcription."

Now that this cancer-promoting molecular pathway has been described, Yeh says it might be possible to interfere with a number of the players to inhibit cancer growth. "NEDD8 is key," he said. "It may be possible to design drugs that block the removal of NEDD8 from BCA3." By increasing the amount of NEDD8-modified BCA3, there will be a corresponding decrease in the level of NFkB and the cancer cells will be more sensitive to chemotherapy, Yeh says.

"There is a lot we need to sort out, of course, but this is a model of how estrogen may function to promote growth in breast cancer that we can all now work from," Yeh says.
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Source:University of Texas M. D. Anderson Cancer Center


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