Navigation Links
New path from estrogen to survival in breast cancer cells described

After years of research, scientists at The University of Texas M. D. Anderson Cancer Center are now able to explain, in exquisite molecular detail, how the estrogen hormone can help keep breast cancer cells alive.

In the Sept. 24 issue of the journal, Nature Cell Biology, they assign roles to a number of genes and proteins thought to play a part in breast cancer cell survival, and in the process, have identified potential molecular drug targets.

"It's a very complex story, but we have been able to bring together a number of basic discoveries from different fields of research to work out the basic mechanism by which estrogen can exert a pro-life effect on cancer cells," said the study's lead author, Edward T. H. Yeh, M.D., professor and chair of The University of Texas M. D. Anderson's Department of Cardiology.

Along the way, the researchers have provided some novel insights. One is that they have provided a role for breast cancer-associated protein 3 (BCA3), which had been recently found to be over-expressed in both breast and prostate cancers. Yeh and his team show that this protein, by itself, doesn't have any relationship to the cancer, but when modified by the protein NEDD8, can act like a tumor suppressor.

The researchers also found that SIRT1, a key protein involved in this molecular pathway, is a member of a family of proteins responsible for prolonging life span in both yeast and worms. "The fact that these molecules, which maintain life span in other species, has been found to be involved in suppressing cancer development seems important to us," Yeh said. "The reason people live longer is that they don't develop cancer as readily."

Players in this newly defined pathway are:

  • BCA3, which had no known function.
  • NEDD8, a protein that can bind to other proteins and alter their function.
  • SENP8, a protease (enzyme) that can break bonds between other molecules.
  • SIRT1
  • NFkB (Nuclear Factor ka
    '"/>


Source:University of Texas M. D. Anderson Cancer Center


Page: 1 2 3

Related biology news :

1. Harmful chemicals may reprogram gene response to estrogen
2. Compounds in plastic packaging act as environmental estrogens altering breast genes
3. Tamoxifen-like drug suggests new ways to selectively block estrogen
4. Researchers uncover mechanisms of estrogen in promoting cell death in breast cancer
5. High estrogen levels associated with dementia in older men
6. Ultra low-dose estrogen shown safe for post-menopausal women
7. Changing length of days reverses how estrogen affects aggressiveness in mice
8. Molecular atlas provides new tool for understanding estrogen-fueled breast cancer
9. The Bacterias guide to survival
10. Boosting HIV screening can increase survival and is cost effective
11. Researchers identify protein crucial for survival of Lyme-disease bacterium
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New path from estrogen survival breast cancer cells described

(Date:10/29/2014)... held in New York City on September 19, 2014, ... Cancer Society Professor of Genome Sciences and Medicine at ... Doctor of Philosophy of Tel Aviv University, was awarded ... , In addition to her honorary degree from TAU, ... TAU School of Medicine, and for the past 18 ...
(Date:10/29/2014)... is available in German . ... Gabriela Cabral and Peter Schlögelhofer at the Max F. ... the Medical University of Vienna dived into the process ... these plants display an inversion of the standard meiotic ... scientific journal Nature Communications . , Meiosis is ...
(Date:10/29/2014)... of the Barcode of Life Data Systems ... Biodiversity Data Journal (BDJ) used specimen records ... into a human-readable text developed in manuscript within the ... to study the species distributions of ten Nearctic species ... is originally designed to support the generation and application ...
Breaking Biology News(10 mins):Geneticist and humanitarian: Prof. Mary-Claire King receives Lasker Award 2Meiotic cell division 'the other way round' 2Go straight and publish: From Barcode of Life Data Systems to scholarly publishing systems 2
... is a key requirement for good health and alternative cheap, ... that has just been published in the leading American Chemical ... University in co-operation with The University of Botswana describe how ... used for water purification. Flocculation of particulate impurities ...
... A rapid and unprecedented proliferation of oil and gas ... area leased is on track to reach around 70% ... is one of the central conclusions from a pair ... Ambientals (ICTA) of Universitat Autnoma de Barcelona (UAB), and ...
... for the Advancement of Science (AAAS) meeting is being ... will be presenting on topics ranging from linear colliders ... Also occurring at the end of this year,s ... as the next president of the AAAS. Below is ...
Cached Biology News:Seeds from the Moringa tree can be used for water purification 2A second hydrocarbon boom threatens the Peruvian Amazon 2A second hydrocarbon boom threatens the Peruvian Amazon 3Caltech researchers presenting at AAAS Meeting 2Caltech researchers presenting at AAAS Meeting 3Caltech researchers presenting at AAAS Meeting 4Caltech researchers presenting at AAAS Meeting 5Caltech researchers presenting at AAAS Meeting 6
(Date:10/30/2014)... Dallas, Texas (PRWEB) October 30, 2014 ... China Naltrexone HCL Industry” is a professional and ... The report provides basic Naltrexone HCL information, including ... as well as industry overview. This research covers ... as well as global industry analysis covering macroeconomic ...
(Date:10/30/2014)... Spartan Bioscience announced today that Health Canada has ... detects CYP2C19 genetic mutations in less than 60 minutes ... CYP2C19 System is the first near-patient DNA test for ... to the system’s ease of use, Health Canada has ... such as doctors, nurses, pharmacists, and laboratory technicians, in ...
(Date:10/30/2014)... Oct. 30, 2014 A new report, commissioned ... Practice, takes an in-depth look at Indiana,s ... have resulted over two different time frames: 1993 to ... view of future opportunities for investment growth.  The ... report shows gains in innovation dollars as well ...
(Date:10/27/2014)... (PRWEB) October 27, 2014 The ... by Type (High & Medium), Sub-type (Primary & ... Processing, Infrastructure & Transportation & Power Generation) - ... the GIS market with analysis and forecasting of ... Market Data Tables with 52 Figures spread through ...
Breaking Biology Technology:Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 2Naltrexone HCL Market & Nalbuphine HCL Industry Analysis for Global, China Regions Now at DeepResearchReports.com 3Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4
... Prize, Draper Laboratory, in conjunction with the National Academy of Engineering ... learn about the impact engineers have had on our daily lives, ... been awarded "Engineering,s Nobel" since 1989. , ... Cambridge, ...
... Inc.,(Nasdaq: PCYC ), a developmental stage biopharmaceutical ... late stage preclinical programs,announced today the appointment of a ... Robert W. Duggan, our Chairman of ... acting as interim CEO for the past five months. ...
... Savient Pharmaceuticals, Inc. (Nasdaq: SVNT ) today ... position of Vice President, Chief Financial Officer & Treasurer. ... terminated as Savient,s Chief Financial Officer, effective immediately. ... our current Vice President of Corporate Finance and Controller, ...
Cached Biology Technology:New Educational Website Celebrates the Accomplishments of Engineers 2Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 2Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 3Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 4Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 5Pharmacyclics Announces Appointment of New Management Team and Board Director to Accelerate Its Future Growth 6Savient Announces Appointment of David Gionco as Chief Financial Officer 2Savient Announces Appointment of David Gionco as Chief Financial Officer 3Savient Announces Appointment of David Gionco as Chief Financial Officer 4
... Buffer is a concentrated formulation of a ... capillary action technology, as well as for ... with David Brigati M.D., Department of Pathology, ... buffer is recommended for all the rinsing ...
...
... Intended for users requiring mass detection ... linear MALDI TOF Mass spectrometer is ... applications and for high performance mass ... QA/QC, SNP analysis, protein detection, micro-satellite ...
Rat Aortic Smooth Muscle Cells (RAOSMC) (>500,000 cells)...
Biology Products: