Navigation Links
New neurons take baby steps in the adult brain

they are in the fetal brain or the adult brain, says Song.

"The steps of integration essentially shift the neuron from being a developing neuron to being an adult neuron. Initially it's excited by the flood of GABA, but by the time it's fully integrated, the neuron will respond to GABA and glutamate like other adult neurons," he says.

The researchers' experiments were done on a part of the mouse brain called the dentate gyrus, which is thought to be involved in memory and spatial reasoning, or navigation. It is one of the few parts of the brain where new neurons form throughout life and are integrated into the existing network of cells.

The researchers also figured out why the mouse's new neurons were excited by GABA -- they have greater amounts of chloride ions, making for a different chemical environment. By the time they are fully integrated, their chloride levels have dropped and are similar to other adult neurons.

In the mouse experiments, Goh used a technique to alter the genetics of single cells in order to change new neurons' ability to accumulate chloride ions (and thus to manipulate their response to GABA) and to make them glow with a green protein to ease their identification in the adult brain. Ge measured the electrical output of the neurons to establish whether they had become connected to other neurons.

"Getting new neurons to form connections in other parts of the brain may be helped through the same steps that naturally lead to integration in the dentate gyrus," says Song.

Among the most likely targets for regeneration or replacement efforts are the dopamine-producing neurons that die in Parkinson's disease, muscle-controlling nerves that succumb in diseases like muscular dystrophy and amyotrophic lateral sclerosis, or nerves that are damaged by trauma or injury. In none of these systems are new neurons formed or integrated to any great extent naturally.


'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. First real-time view of developing neurons reveals surprises, say Stanford researchers
2. One gene links newborn neurons with those that die in diseases such as Alzheimers
3. Researchers make surprise discovery that some neurons can transmit three signals at once
4. Speak up: Louder neurons form more connections
5. Eating, body weight regulated by specific neurons
6. Algal protein in worm neurons allows remote control of behavior by light
7. Picking apart how neurons learn
8. Researchers get neurons and silicon talking
9. Mechanism for memory revealed in neurons of electric fish
10. Attention shoppers: Researchers find neurons that encode the value of different goods
11. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New neurons take baby steps the adult brain

(Date:4/15/2014)... April 15, 2014, Irvine, Calif. UC Irvine neurobiologists ... positive results when transplanted into the brains of mice ... pre-clinical trial is published in the journal Stem ... been shown to work in two different mouse models. ... forms of dementia, is associated with accumulation of the ...
(Date:4/15/2014)... Hartford, Connecticut, a Puerto Rican community is creating a ... so authentic it has caught the attention of scientists. ... Anderson (University of Connecticut) took a close look at ... Hartford and uncovered evidence that gives new meaning to ... years: home is in the kitchen. , "Culinary preferences ...
(Date:4/15/2014)... as early as 2020 how high sea levels will ... of researchers including Florida International University scientist Rene Price. ... Foundation,s (NSF) Florida Coastal Everglades Long-Term Ecological Research (LTER) ... ecosystems from coral reefs to deserts, mountains to salt ... level rise is one of the most certain consequences ...
Breaking Biology News(10 mins):UCI study finds modified stem cells offer potential pathway to treat Alzheimer's disease 2The human food connection: A new study reveals more about our relationship to food 2The human food connection: A new study reveals more about our relationship to food 3Long-term predictions for Miami sea level rise could be available relatively soon 2
... University of Maryland Center for Environmental Science researchers gives ... Bay ecological conditions were slightly better than the previous ... healthy Bay. The Chesapeake Bay Health Report ... is nothing here from which we can take great ...
... Tyler J. and Frances F. Young Professor of Bacteriology ... the Virginia-Maryland Regional College of Veterinary Medicine at Virginia ... States Department of Agriculture to study the role biofilm ... (BRDC). The $374,000 grant will allow Inzana and ...
... bird feeders in their backyards each year, often out of ... survey of research on the topic finds that feeding may ... Published as a Frontiers in Ecology and the ... Gillian Robb (Queens University Belfast, UK) and by Stuart Bearhop ...
Cached Biology News:Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007 2Veterinary college researchers explore function of biofilm in bovine respiratory disease 2Food for thought 2
(Date:1/15/2014)... 2014 The Microcompetition with Foreign DNA ... disease. One of these latent viruses is the Epstein ... rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... by the theory, a study found that RA patients ... (1). , What is Microcompetition? , Dr. Hanan ...
(Date:1/15/2014)... Sunnyvale, CA (PRWEB) January 15, 2014 ... of high throughput research solutions, today announced that ... companies, has received delivery of Freeslate’s CM ... form screening. , Lupin, headquartered in Mumbai, ... quality, affordable generic and branded formulations and Active ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, ... Foundation, the only national nonprofit organization solely dedicated to ... quality of life for those affected worldwide, will host ... Warrington Country Club in Warrington, Pa. , Each ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider ... major scientific, regulatory, business, and media events in ... , today announced its former associate Virginia Cox , ... office. Virginia Cox re-joins ... Commissioner for the Office of External Affairs at the U.S. ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... PHILADELPHIA, Oct. 29 GlaxoSmithKline (NYSE:,GSK) (LSE: GSK) ... announced,today that they have entered into a definitive ... approximately $57 million (pounds Sterling 35,million) through a ... This strategic,acquisition will strengthen GSK,s effort to develop ...
... BioAuthorize,Holdings, Inc. and its wholly owned ... high-tech voice biometric security company,providing online payment ... board of directors and restructured its executive ... implementation of its newly developed,biometric authentication services., ...
... Calif., Oct. 29 Sangamo,BioSciences, Inc. (Nasdaq: SGMO ... For the third quarter ended September 30, 2008, ... $0.15 per share, compared to a,net loss of $4.3 ... in 2007.,As of September 30, 2008, the company had ...
Cached Biology Technology:GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 2GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 3GlaxoSmithKline to Acquire Genelabs Technologies to Increase Focus on Novel Small Molecule Therapies for Hepatitis C 4BioAuthorize Holdings, Inc. Names New Directors and Executive and Unveils Modification to Its Voice Biometric Authentication Service 2BioAuthorize Holdings, Inc. Names New Directors and Executive and Unveils Modification to Its Voice Biometric Authentication Service 3BioAuthorize Holdings, Inc. Names New Directors and Executive and Unveils Modification to Its Voice Biometric Authentication Service 4BioAuthorize Holdings, Inc. Names New Directors and Executive and Unveils Modification to Its Voice Biometric Authentication Service 5Sangamo BioSciences Reports Third Quarter 2008 Financial Results 2Sangamo BioSciences Reports Third Quarter 2008 Financial Results 3Sangamo BioSciences Reports Third Quarter 2008 Financial Results 4Sangamo BioSciences Reports Third Quarter 2008 Financial Results 5Sangamo BioSciences Reports Third Quarter 2008 Financial Results 6Sangamo BioSciences Reports Third Quarter 2008 Financial Results 7
... combines a single-channel sample processing head, an ... reagent dispenser all in one compact, affordable ... pipette tips, the Precision XS autoclavable and ... available for transferring larger volumes. Intuitive Precision ...
... races ever faster, you need a partner who ... our constant focus is on providing tools and ... our Biomek 3000 Laboratory Automation Workstation offers a ... is flexible. By integrating all aspects of liquid ...
... Rabbit Tissue Arrays contain 60 rabbit tissue samples ... contains 4 unstained slides and 1 hematoxylin and ... slide contains 15 different tissues from 4 rabbit ... per slide. Each tissue sample (or core) is ...
... with a wide variety of purity levels, scales ... Purity: IG(>50%), >70%, >80% and ... Sequence Length: Up to 120 residues ... D-amino acids, MAPs, KLH/BSA conjugation, and much more. ...
Biology Products: