Navigation Links
New neurons take baby steps in the adult brain

In experiments with mice, scientists from Johns Hopkins' Institute for Cell Engineering have discovered the steps required to integrate new neurons into the brain's existing operations.

For more than a century, scientists thought the adult brain could only lose nerve cells, not gain them, but in fact, new neurons do form during adulthood in all mammals, including humans, and become a working part of the adult brain in mice at the very least.

In the first study to show how these "baby" neurons are integrated into the brain's existing networks, the Johns Hopkins researchers show that a brain chemical called GABA readies baby neurons to make connections to old ones. The discovery is described in the Dec. 11 advance online section of Nature.

"GABA is important during fetal development, but most scientists thought it would have the same role it has with adult neurons, which is to inhibit the cells' signals," says Hongjun Song, Ph.D., an assistant professor in the Neuroregeneration and Repair Program within ICE. "We've shown that GABA instead excites new neurons and that this is the first step toward their integration into the adult brain."

Song added that their discovery might help efforts to increase neuron regeneration in the brain or to make transplanted stem cells form connections more efficiently.

The researchers, including postdoctoral fellows Shaoyu Ge and Eyleen Goh, discovered that a constant flood of GABA is required as a first step. Next, the new neuron receives specific connections that communicate using GABA, which shifts the constant barrage of GABA in step one to a pulsed exposure. The third and final step occurs when the new neuron receives connections that communicate via another chemical, the critical excitatory messenger glutamate.

In the adult brain, glutamate is the most prevalent excitatory chemical, and GABA is a major inhibitory chemical. But it turns out that new neurons are excited by GABA, whether
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. First real-time view of developing neurons reveals surprises, say Stanford researchers
2. One gene links newborn neurons with those that die in diseases such as Alzheimers
3. Researchers make surprise discovery that some neurons can transmit three signals at once
4. Speak up: Louder neurons form more connections
5. Eating, body weight regulated by specific neurons
6. Algal protein in worm neurons allows remote control of behavior by light
7. Picking apart how neurons learn
8. Researchers get neurons and silicon talking
9. Mechanism for memory revealed in neurons of electric fish
10. Attention shoppers: Researchers find neurons that encode the value of different goods
11. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New neurons take baby steps the adult brain

(Date:8/27/2014)... The mechanical force that a single fungal cell or bacterial ... but it plays a heavy role in setting up some ... it may not be too much of a stretch to ... the ability to respond to the touch of beneficial fungi, ... professor of agronomy at the University of Wisconsin-Madison. , ...
(Date:8/27/2014)... Aug. 27, 2014  WaferGen Bio-systems, Inc. (NASDAQ: WGBS) ... underwritten public offering of units of common stock and ... gross proceeds of $20 million, prior to deducting underwriting ... Company.  The shares and warrants are immediately separable and ... sold in the offering consists of 2,000 shares of ...
(Date:8/27/2014)... of North America,s megafauna mastodons, short-faced bears, giant ... disappeared close to 13,000 years ago at the ... massive extinction has long been debated by scientists who, ... A group of scientists, including UC Santa Barbara,s James ... posited that a comet collision with Earth played a ...
Breaking Biology News(10 mins):A touching story: The ancient conversation between plants, fungi and bacteria 2A touching story: The ancient conversation between plants, fungi and bacteria 3WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 2WaferGen Bio-Systems Announces Successful Completion of Public Offering Raising $20 Million 3Nanodiamonds are forever 2Nanodiamonds are forever 3
... expect to live slightly longer than Europeans. This has since ... now live about a year-and-a-half less, on average, than their ... other developed nations. How did Americans fall behind? A ... & Medicine is the first to calculate the fiscal ...
... shows the prevalence of gout in the U.S. has risen ... (4%) Americans. Prevalence of increased uric acid levels (hyperuricemia) also ... frequency of obesity and hypertension may be associated with the ... in Arthritis & Rheumatism , a journal published by ...
... east coast of Canada are showing signs of recovery more ... 1990s, according to research published today in Nature . ... an ecosystem that was pushed out of balance and that ... professor in the Department of Biology, former principal at Queen,s, ...
Cached Biology News:Getting 50-year-old Americans as healthy as Europeans could save Medicare and Medicaid $632 billion by 2050 2Gout prevalence swells in US over last 2 decades 2Cod resurgence in Canadian waters 2
(Date:8/27/2014)... August 27, 2014 Varian Medical Systems ... its current Salt Lake City manufacturing facility and allow ... Utah to ultimately create 1,000 new full time jobs ... , “Utah is home to hardworking people with immense ... credited with Varian’s success in the manufacturing of our ...
(Date:8/27/2014)... Green & Grow Inc. (GGI) has ... and secured Otter Capital as a significant new partner. ... of GGI’s Agriplier™ technology, building on recent compelling field ... our first meeting, we have been impressed with Otter ... said Alan Sobba, President and CEO of GGI. “We ...
(Date:8/27/2014)... -- Rhythm, a biopharmaceutical company developing peptide therapeutics that ... metabolic disorders, announced today that it has filed a ... and Exchange Commission (SEC) relating to the proposed initial ... number of shares to be offered and the price ... Citigroup and Cowen and Company will act ...
(Date:8/27/2014)... Livermore, California (PRWEB) August 27, 2014 ... (LLNL), through Lawrence Livermore National Security ... million to develop and deliver a state-of-the-art laser ... Beamlines facility (ELI Beamlines), under construction in the ... design performance, the laser system, called the " ...
Breaking Biology Technology:Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 2Varian Medical Systems Groundbreaking on Facility Expansion Triggers Influx of New Jobs to Salt Lake 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Rhythm Files Registration Statement for Proposed Initial Public Offering 2LLNL Synchs up with ELI Beamlines on Timing System 2LLNL Synchs up with ELI Beamlines on Timing System 3
... repairing damaged human tissue doesn,t wrinkle up when it ... of California, San Diego marks a significant breakthrough in ... of native human tissue. Shaochen Chen, professor ... Diego Jacobs School of Engineering, hopes future tissue patches, ...
... Mass., May 26, 2011 New England Biolabs (NEB), ... reagents for the life science industry, extends its global ... France, located at Bioparc Genopole in Evry, just south ... Ellard, President and CEO of NEB Inc., was on ...
... 2011 Addressing the issue of data overload from next-generation ... ) today launched its LifeScope™ 2.0 Genomic Analysis Software ... genomic sequencing instruments to study human disease such as cancer. ... A single next generation sequencing instrument can generate nearly 200 ...
Cached Biology Technology:Nanoengineers invent new biomaterial that more closely mimics human tissue 2New England Biolabs Opens New Subsidiary Office in France 2Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software 2Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software 3Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software 4Life Technologies Simplifies, Organizes and Speeds Analysis of Genomic Data Through Launch of New LifeScope Bioinformatics Software 5
This STAT antibody sampler pack contains 8 monoclonal ,STAT antibodies....
Kanamycin is used for selection of resistant bacteria. C18H36N4O11xH2SO4. Contains 10 mg/ml kanamycin (base) utilizing kanamycin sulfate in 0.85% saline....
...
...
Biology Products: