Navigation Links
New neurons could act to alleviate epilepsy

The new neurons generated as a result of neural damage due to epilepsy show a reduced excitability that could alleviate the disorder, researchers have found. The researchers said their results suggest that therapies for epilepsy aimed at inducing neurogenesis could prove effective in alleviating the disorder.

In an article in the December 21, 2006, issue of the journal Neuron, published by Cell Press, Olle Lindvall and colleagues at Lund University Hospital and Stem Cell Center described studies in rats examining neurons generated after an epileptic event has been triggered in the animals.

In their experiments, the researchers compared the properties of new neurons generated in rats allowed to exercise by running on a wheel with those in rats in which epileptic seizures were induced by electrical brain stimulation. Specifically, the researchers analyzed the electrical properties of a type of new cells, called granule cells, in the structure called the dentate gyrus of the hippocampus. This structure is known to be a "gate" for propagation of seizures in the hippocampus, a center for learning and memory.

The scientists?analysis showed that the new neurons in both the runners and the epileptic animals had all the characteristics of mature dentate gyrus cells. However, they found that neurons born into an epileptic environment, compared to the physiological running environment, showed reduced excitatory connectivity to other neurons, as well as increased inhibitory connectivity. Such differences could mean the newly generated neurons "could have significant beneficial effect on the epileptic syndrome," concluded the researchers.

"Our study demonstrates that both a physiological stimulus and an insult to the adult brain trigger the formation of new dentate granule cells, which are functionally integrated into hippocampal neural circuitry," concluded Lindvall and colleagues. They wrote that "following insult, the functional connectivi ty of new neurons seems to develop in order to mitigate the dysfunction in the epileptic brain. These data provide further evidence for a therapeutic potential of endogenous neurogenesis."
'"/>

Source:Cell Press


Related biology news :

1. First real-time view of developing neurons reveals surprises, say Stanford researchers
2. One gene links newborn neurons with those that die in diseases such as Alzheimers
3. Researchers make surprise discovery that some neurons can transmit three signals at once
4. Speak up: Louder neurons form more connections
5. Eating, body weight regulated by specific neurons
6. New neurons take baby steps in the adult brain
7. Algal protein in worm neurons allows remote control of behavior by light
8. Picking apart how neurons learn
9. Researchers get neurons and silicon talking
10. Mechanism for memory revealed in neurons of electric fish
11. Attention shoppers: Researchers find neurons that encode the value of different goods

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2016)... UAE, April 20, 2016 The ... as a compact web-based "all-in-one" system solution for all ... fingerprint reader or the door interface with integration authorization ... access control systems. The minimal dimensions of the access ... into the building installations offer considerable freedom of design ...
(Date:4/14/2016)... April 14, 2016 BioCatch ... Detection, today announced the appointment of Eyal Goldwerger ... role. Goldwerger,s leadership appointment comes at a ... of the deployment of its platform at several of ... technology, which discerns unique cognitive and physiological factors, is ...
(Date:3/31/2016)... R.I. , March 31, 2016  Genomics firm ... of founding CEO, Barrett Bready , M.D., who ... members of the original technical leadership team, including Chief ... President of Product Development, Steve Nurnberg and Vice President ... returned to the company. Dr. Bready served ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Rolf ... join the faculty of the University of North Carolina Kenan-Flagler Business School ... and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international efforts, ...
(Date:6/24/2016)... ... 2016 , ... While the majority of commercial spectrophotometers and fluorometers use the ... models are higher end machines that use the more unconventional z-dimension of 20mm. ... the bottom of the cuvette holder. , FireflySci has developed several Agilent flow ...
(Date:6/23/2016)... 2016 /PRNewswire/ - FACIT has announced the creation ... biotechnology company, Propellon Therapeutics Inc. ("Propellon" or "the ... a portfolio of first-in-class WDR5 inhibitors for the ... WDR5 represent an exciting class of therapies, possessing ... for cancer patients. Substantial advances have been achieved ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
Breaking Biology Technology: