Navigation Links
New nanotechnology able to examine single molecules, aiding in determining gene expression

A new nanotechnology that can examine single molecules in order to determine gene expression, paving the way for scientists to more accurately examine single cancer cells, has been developed by an interdisciplinary team of researchers at UCLA's California Nanosystems Institute (CNSI), New York University's Courant Institute of Mathematical Sciences, and Veeco Instruments, a nanotechnology company. Their work appears in the January issue of the journal Nanotechnology.

Previously, researchers have been able to determine gene expression using microarray technology or DNA sequencing. However, such processes could not effectively measure single gene transcripts—the building blocks of gene expression. With their new approach, the researchers of the work reported in Nanotechnology were able to isolate and identify individual transcript molecules—a sensitivity not achieved with earlier methods.

"Gene expression profiling is used widely in basic biological research and drug discovery," said Jason Reed of UCLA's Department of Chemistry and Biochemistry and the study's lead author. "Scientists have been hampered in their efforts to unlock the secrets of gene transcription in individual cells by the minute amount of material that must be analyzed. Nanotechnology allows us to push down to the level of individual transcript molecules."

"We are likely to see more of these kinds of highly multi-disciplinary research aimed at single molecule sequencing, genomics, epigenomic, and proteomic analysis in the future," added Bud Mishra, a professor of Computer Science, Mathematics, and Cell Biology from NYU's Courant Institute and School of Medicine. "The most exciting aspect of this approach is that as we understand how to intelligently combine various components of genomics, robotics, informatics, and nanotechnology—the so-called GRIN technology—the resulting systems will become simple, inexpensive, and commonplace."


'"/>

Source:New York University


Page: 1

Related biology news :

1. Revolutionary nanotechnology illuminates brain cells at work
2. Silver bullet: UGA researchers use laser, nanotechnology to rapidly detect viruses
3. Iowa State scientists demonstrate first use of nanotechnology to enter plant cells
4. U of M researcher examines newly emerging deadly disease
5. A new study examines how shared pathogens affect host populations
6. New study examines how sense of smell affects mating and aggression in mice
7. New research examines genetics of successful aging
8. UCLA paper examines how one disease may prevent another
9. U of M study examines kidney stone prevention in astronauts
10. New research examines genetics of successful aging
11. Plants role in global warming re-examined
Post Your Comments:
(Date:8/21/2014)... geologist Juliane Mller the Fram Strait is a key region ... this passage between Greenland and Svalbard warm Atlantic water flows ... west side cold Arctic water masses and sea ice push ... A considerable portion of the Atlantic water cools here on ... The circulation of the water caused in this manner drives ...
(Date:8/21/2014)... standards process, will be available soon and will improve ... in the OnlineFirst version of Nutrition in Clinical ... the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), ... misconnection that can be harmful and even fatal to ... medical devices, components, and accessories to deliver fluids or ...
(Date:8/21/2014)... involves the pancreas digesting itself resulting in severe abdominal ... UK around 20,000 patients are diagnosed with the disease ... and treatment is restricted to intravenous fluid and nutritional ... of Life Sciences, who led the research, said "The ... gall stones and excessive alcohol intake combined with a ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3New feeding tube connectors will improve patient safety 2Insulin offers new hope for the treatment of acute pancreatitis 2
... you get a picky young eater who refuses everything to ... try nutritious foods when all they want is something sweet ... mealtime struggles? In her new book, ... to Raise Healthy Eaters" (Healthy Learning, May 2012), registered dietitian ...
... (May 29, 2012) Physicians and researchers at John Theurer ... cancer centers, will present the latest findings in blood-cancer research ... meeting in Chicago on June 1-5. Their involvement in these ... to bolster its research program. "We are ...
... Organic Electronics research group at Linkping University previously developed ... ions, as well as biomolecules. Tybrandt has now succeeded ... a similar way to traditional silicon-based electronics. ... carrier consists of chemical substances with various functions. This ...
Cached Biology News:'Eat your vegetables!' New book redefines how to raise healthy eaters 2John Theurer Cancer Center presents significant blood cancer research at 2012 ASCO Annual Meeting 2
(Date:8/20/2014)... analysis of patented university inventions licensed to biotechnology ... to commercialization. To open these roadblocks, the researchers ... during the discovery stage could lead to faster ... frequently derived from discoveries made in university laboratories ... known during clinical trials, which have a high ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 High ... and apply the most complete climate and Earth ... demanding climate change issues. , Eight national laboratories, ... with the National Center for Atmospheric Research, four ... new effort. Other participating national laboratories include Argonne, ...
(Date:8/20/2014)... (PRWEB) August 20, 2014 Not long ... E&L studies should be performed late in the development ... known. But current regulatory trends suggest that, like many ... the rise. In recent years, multiple drug sponsors have ... or address specific questions during phase I/II. It’s not ...
(Date:8/20/2014)... Sofia, Bulgaria (PRWEB) August 20, 2014 ... was released today including improvements to the ... rates and connectors for Lucene, SOLR and Elasticsearch. ... change for this high performance triplestore – GraphDB™ ... organizations interested in deploying the only mature enterprise ...
Breaking Biology Technology:Early bottlenecks in developing biopharmaceutical products delay commercialization 2Early bottlenecks in developing biopharmaceutical products delay commercialization 3New Project Is the ACME of Addressing Climate Change 2New Project Is the ACME of Addressing Climate Change 3Are Extractable and Leachables going Phase-Appropriate? New Webinar Hosted by Xtalks 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4
... Thomson Reuters, the,world,s leading source of intelligent ... the National Cancer Institute (NCI) has,joined the ... comprehensive resource for biomarker intelligence to provide,pharmaceutical, ... for assessing and tracking a potential biomarker ...
... ... Initiatives, BEDFORD, Mass., Sept. 3 ... technology with its OmniPod(R),Insulin Management System, today announced the appointment of ... this,role, Mr. Arthur will lead the company,s business development strategy,including pursuing ...
... a Magellan,Biosciences company and leader in novel HPLC ... QA/QC, life science, and,analytical-chemistry customers worldwide, announced that ... American Technology Innovation Award in the,field of integrated ... to ESA,s Vice President of HPLC Products and ...
Cached Biology Technology:The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters 2The National Cancer Institute Joins the Global Community of Scientists Now Using BIOMARKERcenter From Thomson Reuters 3Insulet Appoints Bill Arthur as Vice President of Business Development 2Insulet Appoints Bill Arthur as Vice President of Business Development 3Insulet Appoints Bill Arthur as Vice President of Business Development 4ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems 2ESA Receives 2008 Frost & Sullivan North American Technology Innovation Award for Development of Integrated Metabolomics Systems 3
... The "egg crate" style strip holder is ... bottom strips. Linkage: This CLS number is ... match Cornings product number. If showing no ... Sigma-Aldrich number (Z71,456-9) or contact customer service ...
... Streptavidin-AP Systems provide rapid, precise localization ... in frozen or paraffin-embedded tissue, cytospins ... also facilitate double or triple labeleing ... simultaneously with primary antibodies of different ...
Designed for use with all 96-well SPRI reagent kits. Used with round bottom 96-well microplates, and 96-well thermal cycling plates....
... pre-amplifier suitable for a broad range of ... recording physiological signal such as ECG, EMG, ... for use with a wide range of ... a stimulus artefact clamp to avoid saturation ...
Biology Products: