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New nanosensor uses quantum dots to detect DNA

e probes is a complement to the DNA sequence the researchers are searching for. Therefore, the probes seek out and bind to the target DNA.

Each DNA probe also has an important partner. Attached to one is a Cy5 molecule that glows when it receives energy. Attached to the second probe is a molecule called biotin. Biotin sticks to yet another molecule called streptavidin, which coats the surface of the quantum dot.

To create their nanosensor, the researchers mixed the two DNA probes, plus a quantum dot, in a lab dish containing the DNA they were trying to detect. Then nature took its course. First, the two DNA probes linked up to the target DNA strand, holding it in a sandwich-like embrace. Then the biotin on one of the probes caused the DNA "sandwich" to stick to the surface of the quantum dot.

Finally, when the researchers shined a laser on the mix, the quantum dot passed the energy on to the Cy5 molecule that was attached to the second probe. The Cy5 released this energy as a fluorescent glow. If the target DNA had not been present in the solution, the four components would not have joined together, and the distinctive glow would not have appeared. Each quantum dot can connect to up to about 60 DNA sequences, making the combined glow even brighter and easier to see.

To test the new technique, Wang's team obtained DNA samples from patients with ovarian cancer and detected DNA sequences containing a critical mutation. "This method may help us identify people at risk of developing cancer, so that treatment can begin at a very early stage," Wang said.


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Source:Johns Hopkins University


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