Navigation Links
New nanosensor uses quantum dots to detect DNA

Using tiny semiconductor crystals, biological probes and a laser, Johns Hopkins University engineers have developed a new method of finding specific sequences of DNA by making them light up beneath a microscope.

The researchers, who say the technique will have important uses in medical research, demonstrated its potential in their lab by detecting a sample of DNA containing a mutation linked to ovarian cancer.

The Johns Hopkins team described the new DNA nanosensor in a paper published in the November 2005 issue of the journal Nature Materials.

"Conventional methods of finding and identifying samples of DNA are cumbersome and time-consuming," said Jeff Tza-Huei Wang, senior author of the paper and supervisor of the research team. "This new technique is ultrasensitive, quick and relatively simple. It can be used to look for a particular part of a DNA sequence, as well as for genetic defects and mutations."

The technique involves an unusual blend of organic and inorganic components. "We are the first to demonstrate the use of quantum dots as a DNA sensor," Wang said.

Quantum dots are crystals of semiconductor material, whose sizes are only in the range of a few nanometers across. (A nanometer is one-billionth of a meter.) They are traditionally used in electronic circuitry. In recent years, however, scientists have begun to explore their use in biological projects.

Wang, an assistant professor in the Department of Mechanical Engineering and the Whitaker Biomedical Engineering Institute at Johns Hopkins, led his team in exploiting an important property of quantum dots: They can easily transfer energy. When a laser shines on a quantum dot, it can pass the energy on to a nearby molecule, which in turn emits a fluorescent glow that is visible under a microscope.

But quantum dots alone cannot find and identify DNA strands. For that, the Johns Hopkins team used two biological probes made of synthetic DNA. Each of thes
'"/>

Source:Johns Hopkins University


Page: 1 2

Related biology news :

1. Study shows nanoshells ideal as chemical nanosensors
2. Method slashes quantum dot costs by 80 percent
3. Protein enables discovery of quantum effect in photosynthesis
4. Novel technology detects human DNA mutations
5. Researchers find how protein allows insects to detect and respond to pheromones
6. Scientists detect probable genetic cause of some Parkinsons disease cases
7. Development of portable infectious disease detector
8. Novel ultrafast laser detection of cancer cells also may improve understanding of stem cells
9. Yale researchers identify molecule for detecting parasitic infection in humans
10. Robot-based system developed at Carnegie Mellon detects life in Chiles Atacama desert
11. Products containing specific probes for detecting alternative splice forms protected
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New nanosensor uses quantum dots detect DNA

(Date:5/20/2015)... 20, 2015 ... announced the addition of the  "5-year ... Recognition Market"  report to their offering.  ... service analyses trends in the iris ... commercial sectors, globally. Despite hardware pricing ...
(Date:5/19/2015)... GOTHENBURG, Sweden , May 18, 2015 ... touch fingerprint sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from ... place from June until and including Q3 2015 and the ... Asia . Communicated order values for 2015 hereby amount ... revenues for Q1 2015 of 140 MSEK and a number ...
(Date:5/19/2015)... 19, 2015 Research ... addition of the  "Genetic Testing Market Outlook ... http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent report, Genetic Testing ... of the current and future genetic testing ... their working principles and types are covered ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Global Genetic Testing Market Outlook 2018 2
... Bolton Landing, N.Y. Prior to the federal Clean Air ... the Midwestern and Eastern United States for decades. Many of ... the form of acid rain, a chemical concoction that includes ... acid rain can severely decrease the diversity of plant and ...
... The hardiest plants and those most likely to survive ... now easier to identify, thanks to new research findings ... speed at which plants are likely to migrate during ... says Queen,s Biology professor Christopher Eckert. Populations of ...
... a man by his cologne isn,t as superficial as ... sophisticated machinery to analyze hundreds of chemical components in ... males are not only advertising their fitness for fatherhood, ... well. "We now know that there,s information ...
Cached Biology News:Database shows effects of acid rain on microorganisms in Adirondack Lakes 2Database shows effects of acid rain on microorganisms in Adirondack Lakes 3Life on the edge: To disperse, or become extinct? 2Primate's scent speaks volumes about who he is 2Primate's scent speaks volumes about who he is 3
(Date:5/28/2015)... Biscayne Pharmaceuticals, Inc ., today announced ... hormone-releasing hormone (GHRH) technology will be discussed in a ... The data show that the family of receptors for ... present on many primary breast cancer cells regardless of ... could have broad anti-cancer potential in breast cancer. 1 ...
(Date:5/28/2015)... Glenn Keet, CEO of Clinovo ... EMR/EHR Clinical Data Integration with EDC Systems ” at ... DC on June 14th-18th. , During the presentation, Glenn ... with EDC, and will examine the value of patient ... electronic health records/electronic medical records integration. , The ...
(Date:5/28/2015)... Rochelle, Virginia (PRWEB) May 28, 2015 ... Partners LLC announced today that Roger L. Williams, ... Expert consultant. NDA Partners Premier Experts are top ... them to bring extraordinary value to the company’s ... critical solutions to help clients successfully develop their ...
(Date:5/27/2015)... Mass. , May 27, 2015 ... biotechnology company focused on discovering and developing innovative ... ophthalmology, today announced that it has commenced a public ... to purchase shares of its common stock and ... common stock. The shares of common stock, warrants ...
Breaking Biology Technology:Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 2Data Presented At 2015 ASCO Annual Meeting Shows Biscayne Pharmaceuticals' GHRH Antagonist Target Is Expressed Across All Breast Cancer Subtypes 3Clinovo Presents at the DIA 2015 51st Annual Meeting in Washington, DC on June 14th-18th 2Former CEO and Chair of the Council of Experts at the USP, Roger L. Williams, MD, Joins NDA Partners as a Premier Expert Consultant 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces Proposed Public Offering of Common Stock and Warrants 3
... March 12 A company here is expanding to ... kind that open drain pipes, clean up soil and ... and vegetables.Osprey Biotechnics is quadrupling its output this year ... that,s a lot of bacteria -- about 1.1 trillion ...
... March 12 Proposed legislation that creates a regulatory ... medicines represents a critical step forward in providing more ... and complex conditions, David B. Snow Jr., chairman and ... MHS ) said today."The investment in research and innovation ...
... CASTLE, Del., March 12 -- Arkion(R) Life Sciences has ... AV-1011 Liquid Rice Seed Treatment in Louisiana and Missouri ... The EPA approval means that rice growers in these ... grackles. The new bird repellent effectively stops birds ...
Cached Biology Technology:Osprey Biotechnics: More Trillions of Good Bacteria 2Biogenerics Legislation Provides Critical Pathway to Affordable Access for Patients with Chronic and Complex Conditions 2Biogenerics Legislation Provides Critical Pathway to Affordable Access for Patients with Chronic and Complex Conditions 3AV-1011 Bird Repellent to Protect Rice Seed Approved for Use in Louisiana and Missouri 2
Request Info...
... is a nonspecific endonuclease that degrades double-and ... hydrolyzing phosphodiester linkages, producing mono and oligonucleotides ... Ambion's RNase-free DNase I is of the ... degrade DNA in the presence of RNA ...
hnRNP U (H-94)...
... GELase™ Agarose Gel-Digesting Preparation contains a unique ... simple, quantitative recovery of intact DNA and ... gels following electrophoresis in TAE, TBE, MOPS, ... digested directly in the TAE, TBE, MOPS, ...
Biology Products: