Navigation Links
New nano-canary in the nanotoxicology coalmine: The body itself

There is growing consensus among scientists, regulators, politicians, industry and the public that we need to know more about the possible harmful or adverse effects of nanoparticles on human health.

Likewise, most agree that these incredibly small materials can behave quite differently from conventional materials. Nonetheless, neighborhood stores feature products that promise benefits from these near-atomic level materials, from paints and cosmetics to toothpaste and sunscreens. But, could we be putting human health at risk by exposing consumers to potentially toxic materials?

To investigate the damage potential of sub-micron sized particles, S.K. Sundaram and Thomas J. Weber, scientists at the Department of Energy's Pacific Northwest National Laboratory in Richland, Wash., have harnessed living cells to monitor responses to a variety of biologically active test agents. They presented their findings Friday at the American Association for the Advancement of Science annual meeting.

"Our process requires that live cells be grown on an infrared transparent substrate giving us an opportunity to closely examine the biological effects in living cells," said Sundaram. Live cell Fourier transform infrared, FTIR, spectroscopy offers several attractive features for these investigations. These include the potential to detect biologically active nanoparticles without any prior knowledge of cell signaling pathways affected by them or need of a contrast agent to detect the biological response. Thus, live cell FTIR spectroscopy is expected to be a sentinel of exposure to help identify the physico-chemico properties of nanoparticles that mediate biological activity, without bias of what that biological activity represents.

The PNNL scientists are also developing infrared transparent chemistries that are expected to improve FTIR measurements in live cell experiments. "We believe this report outlines the first use of FTIR spectroscopy to exami ne the biological response of living cells to nanoparticles, and expect this technology will enable us to identify chemical changes associated with the biological response," said Weber. FTIR spectroscopy measures a broad spectrum of chemical bonds and will provide information that is complementary to genomic and proteomic approaches.

FTIR spectra are captured in minutes in live cell studies, offering a tool to rapidly detect whether nanoparticles are biologically active. This information can be used to prioritize nanoparticles for further study to ascertain the nature of the biological activity in terms of toxicity.

A broader approach underway at PNNL for discovering what environmental nanomaterials can do once they enter the body ?and how they enter and where they go ?is part of a large collaborative effort funded by NIH, DOE and private industry. This research is aimed at developing predictive respiratory system models for laboratory animals and humans. A key component of this multi-institution collaborative effort is a $10 million, 5-year Bioengineering Research Partnership, BRP, funded by the National Heart Lung and Blood Institute that is designed to devise 3-D imaging and computational models that provide unsurpassed detail of respiratory systems in humans and other mammals.

Advancements in medical imaging, data analysis and computation have increased "the speed and accuracy of developing detailed models of the complete respiratory system," reported Richard Corley, PNNL staff scientist and director of the multi-institutional BRP. "New imaging techniques also show promise for validating particle deposition models. Atlases of airway geometries and functional characteristics are also being constructed to facilitate analyses of variability, reduce uncertainties in animal to human extrapolations and contribute to a more quantitative representation of environment-disease interactions."


'"/>

Source:DOE/Pacific Northwest National Laboratory


Related biology news :

1. A bathroom that cleans itself
2. New stem-cell findings can help the body to cure itself
3. Smart genetic therapy helps the body to heal itself
4. No carrier necessary: This drug delivers itself
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/3/2017)... April 3, 2017  Data captured by ... platform, detected a statistically significant association between ... to treatment and objective response of cancer ... to predict whether cancer patients will respond ... as well as to improve both pre-infusion potency ...
(Date:3/29/2017)... 29, 2017  higi, the health IT company that ... North America , today announced a Series B ... of EveryMove. The new investment and acquisition accelerates higi,s ... to transform population health activities through the collection and ... higi collects and secures data today on behalf ...
(Date:3/24/2017)... -- Research and Markets has announced the addition of ... - Industry Forecast to 2025" report to their offering. ... The Global Biometric Vehicle ... around 15.1% over the next decade to reach approximately $1,580 million ... estimates and forecasts for all the given segments on global as ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... (PRWEB) , ... October 11, 2017 , ... ComplianceOnline’s Medical ... place on 7th and 8th June 2018 in San Francisco, CA. The Summit brings ... well as several distinguished CEOs, board directors and government officials from around the world ...
(Date:10/11/2017)... ... 11, 2017 , ... Disappearing forests and increased emissions are the main causes ... each year. Especially those living in larger cities are affected by air pollution related ... the most pollution-affected countries globally - decided to take action. , “I knew I ...
(Date:10/10/2017)... Los Angeles, CA (PRWEB) , ... ... ... Pharmaceuticals, Inc., a development-stage cancer-focused pharmaceutical company advancing targeted antibody-drug conjugate (ADC) ... all uses of targeted HPLN (Hybrid Polymerized Liposomal Nanoparticle), a technology developed ...
(Date:10/10/2017)... Oct. 10, 2017 SomaGenics announced the receipt ... to develop RealSeq®-SC (Single Cell), expected to be the ... RNAs (including microRNAs) from single cells using NGS methods. ... need to accelerate development of approaches to analyze the ... "New techniques for measuring levels of mRNAs in ...
Breaking Biology Technology: