Navigation Links
New method for identifying microbes

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory have developed a new, high-throughput technique for identifying the many species of microorganisms living in an unknown "microbial community." The method, described in the March 2006 issue of Applied Environmental Microbiology, has many applications -- from assessing the microbes present in environmental samples and identifying species useful for cleaning up contamination to identifying pathogens and distinguishing harmless bacteria from potential bioterror weapons.

"Microbial communities are enormously diverse and complex, with hundreds of species per milliliter of water or thousands per gram of soil," said Brookhaven biologist Daniel (Niels) van der Lelie, lead author of the study. "Elucidating this complexity is essential if we want to fully understand the roles microbes play in global cycles, make use of their enormous metabolic capabilities, or easily identify potential threats to human health."

Growing cultures of microbes to identify species is slow and error prone as the culture conditions often screen out important members of the community. Sequencing entire genomes, while highly specific and informative, would be too labor intensive and costly. So scientists have been searching for ways to identify key segments of genetic code that are short enough to be sequenced rapidly and can readily distinguish among species.

The Brookhaven team has developed just such a technique, which they call "single point genome signature tagging." Using enzymes that recognize specific sequences in the genetic code, they chop the microbial genomes into small segments that contain identifier genes common to all microbial species, plus enough unique genetic information to tell the microbes apart.

In one example, the scientists cut and splice pieces of DNA to produce "tags" that contain 16 "letters" of genetic code somewhat "upstream" from the beginning of the gene that codes
'"/>

Source:DOE/Brookhaven National Laboratory


Page: 1 2

Related biology news :

1. Color-blind method opens new doors in DNA sequencing
2. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
3. Studies reveal methods viruses use to sidestep immune system
4. An entropy-based gene selection method for cancer classification using microarray data
5. New methods of gene delivery using lasers
6. Breakthrough method in nanoparticle synthesis paves the way for new pharmaceutical and biomedical applications
7. Shift of weather patterns necessitates rethinking of reforestation methods
8. Scientists use manufacturing methods to reconstruct mastodon
9. Researchers develop promising new gene network analysis method
10. New method shows it is possible to grow bone for grafts within a patients body
11. Researchers develop new method for facile identification of proteins in bacterial cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New method for identifying microbes

(Date:10/17/2014)... German . Why ... order to reproduce? And why are there two sexes anyway? ... issue of the research journal Molecular Human Reproduction ... from Bielefeld University Bielefeld has compiled this special issue on ... female to copulate with several males in quick succession – ...
(Date:10/16/2014)... wages war on the human body. Battles are ... In pancreatic cancer, this stalemate—known as tumor dormancy—can ... malignant, a phenomena that is poorly understood. ... laboratory of Salvatore Torquato, a Professor of Chemistry ... surrounding tumor dormancy and the switch to a ...
(Date:10/16/2014)... thinking on how the bowel lining develops and, in ... cancer starts. , The researchers produced evidence that stem ... that are a feature of the bowel lining, and ... development, a controversial finding as scientists are still divided ... technologies, Dr Chin Wee Tan and Professor Tony Burgess ...
Breaking Biology News(10 mins):Sperm wars 2Modeling tumor dormancy 2Cryptic clues drive new theory of bowel cancer development 2
... 2004, Washington University in St. Lous researcher Jianmin Cui was ... channel his lab had been studying for five years. ... a large family whose members suffered from epilepsy, sudden attacks ... and paroxysmal dyskinesia (GEPD). By analyzing the DNA of ...
... attacks in the United States are fostering development of ... to protect people against the potentially deadly bacteria in ... sweeping overview of scientific research on medical technology to ... Journal of Medicinal Chemistry . In ...
... are reporting that particle size affects the toxicity of zinc ... 100 nanometers are slightly more toxic to colon cells than ... equivalent amounts of soluble zinc, and direct particle to cell ... in ACS, Chemical Research in Toxicology , a monthly ...
Cached Biology News:Solving the puzzle of the BK ion channel 2Solving the puzzle of the BK ion channel 3Solving the puzzle of the BK ion channel 4Solving the puzzle of the BK ion channel 5New medical weapons to protect against anthrax attacks 2
(Date:10/20/2014)... Oct. 20, 2014 Asterias Biotherapeutics, Inc. ... has signed a Notice of Grant Award (NGA) ... effective October 1, 2014.  The NGA provides for ... the release of additional grant funds pursuant to ... for clinical development of Asterias, product, AST-OPC1. The ...
(Date:10/20/2014)... , Oct. 20, 2014 PureTech , ... tackling big healthcare problems, announced today the closing ... with participation from Invesco Perpetual, a $120 Billion ... to drive PureTech,s existing pipeline forward and to ... has the scientific creativity to really go for ...
(Date:10/19/2014)... The Latin American hardware encryption display market report ... analysis and forecast of revenue. This market was valued ... reach $2,366.8 million by 2018, at a CAGR of ... TOC of the Latin American hardware encryption market report ... It also provides a glimpse of the segmentation of ...
(Date:10/19/2014)... The Asian Automatic patient billing report defines and ... of revenue. The Automatic patient billing market in Asia ... 2018, at a developing CAGR of 7.2% from 2013 ... Asian Automatic patient billing market, to get an idea ... glimpse of the segmentation of this market in the ...
Breaking Biology Technology:Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 2Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 3Asterias Biotherapeutics Announces Notice of Grant Award with CIRM for Phase 1/2a Clinical Trial of AST-OPC1 in Complete Cervical Spinal Cord Injury 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 2PureTech Announces Expansion with Oversubscribed $55M Funding Round 3PureTech Announces Expansion with Oversubscribed $55M Funding Round 4PureTech Announces Expansion with Oversubscribed $55M Funding Round 5PureTech Announces Expansion with Oversubscribed $55M Funding Round 6The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 2The Latin American hardware encryption display market is expected to reach $2,366.8 million by 2018 - New Report by MicroMarket Monitor 3The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 2The Asian Automatic patient billing market is estimated to grow to around $463.9 million by 2018 - New Report by MicroMarket Monitor 3
... HUNTINGTON BEACH, California and AMSTERDAM, September ... today announced the,successful closing of a US $23 million ... undisclosed family investment firm that provided,approximately half of the ... of US $1 million each, while the remaining,capital was ...
... , ATLANTA, Sept. 22 The International ... Rose Associates has joined its global network. IESF is the ... welcome Sanford Rose Associates (SRA) as one of its global ... offices primarily located throughout the USA will considerably enhance IESF,s ...
... , , PRINCETON, N.J., Sept. 22 ... clinical development services to innovative pharmaceutical, biotechnology, generic drug ... Brennan has joined the Company as general counsel. , ... have Chris join the PharmaNet Development Group management team," ...
Cached Biology Technology:Agendia Raises US $23 Million in Series E Financing 2Sanford Rose Associates Joins the International Executive Search Federation 2Christopher Brennan Joins PharmaNet Development Group as General Counsel 2
...
DTT 50 l...
...
Chicken polyclonal to YebU ( Abpromise for all tested applications). Antigen: Synthetic peptide, corresponding to amino acids 196-244 of E. coli YebU....
Biology Products: