Navigation Links
New mechanism for essential genome-wide gene silencing identified

Most of the time in most cells of the body, the great majority of genes are silenced, locked away within the compacted but orderly material that makes up chromosomes. Estimates are that only about 10 percent of the roughly 25,000 genes in the human genome are activated, or "on," at any given time in a particular cell ?the default setting for most genes is "off," or repressed.

Reliable gene silencing is vital to the health of an organism. Improperly activated genes can and do lead to cancer, for example. Gene silencing is also thought to protect the genome from viruses and other potentially damaging entities, thus preserving genetic integrity.

In a new study, researchers at The Wistar Institute and colleagues have identified an important new global mechanism for this essential gene silencing, or gene repression. A report on the findings appears in the April 15 issue of Genes & Development.

"We've discovered what looks to be an evolutionarily ancient mechanism for broadly repressing and protecting the genome," says Shelley L. Berger, Ph.D., the Hilary Koprowski Professor at The Wistar Institute and senior author on the study. "We believe it to be the first identified mechanism of its kind."

The new mechanism centers on histones, relatively small proteins around which DNA is coiled to create structures called nucleosomes. Compact strings of nucleosomes, then, form into chromatin, the substructure of chromosomes.

In the study, conducted in a type of yeast called Saccharomyces cerevisiae, the scientists showed that a protein called SUMO binds to histones and acts to repress transcription of genes, and it does so at many different sites across the genome. While several other histone-related mechanisms have been identified for activating genes in yeast, this is the first one recognized as repressing gene transcription.

The finding is significant because gene-regulation strategies first observed yeast and other lower-orde
'"/>

Source:The Wistar Institute


Page: 1 2

Related biology news :

1. A new mechanism of regulating RNA degradation
2. Plants, animals share molecular growth mechanisms
3. PET/MRI scans may help unravel mechanisms of prenatal drug damage
4. Researchers discover molecular mechanism that desensitizes us to cold
5. Chemists identify immune system mechanism for methamphetamine binges
6. Key mechanism in genetic inheritance during cell division identified
7. Researchers unlock mechanism creating jigsaw puzzle-like plant cells
8. Mouse gene shows new mechanism behind cardiac infarction in man
9. UCSD research reveals mechanism involved with type of fatal epilepsy
10. Ancient immune defense mechanism is no match for HIV-1
11. Malaria mechanism revealed
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New mechanism for essential genome wide gene silencing identified

(Date:1/22/2015)... , January 22, 2015 , ... tenth year  The European Patent Office to present a ... Two British nominations to be featured: Christofer Toumazou and ... featuring former finalists and winners of the Award   ...
(Date:12/22/2014)... 2014  NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... the growing mobile commerce market, announces it has retained famous ... the 2015 International CES debut of the Wocket™ biometric smart ... at the NXT-ID booth January 6th and 7 th , ...
(Date:12/19/2014)... Inc., the leading personal genetics company, today announced the publication ... of individuals from across the United States ... hundred years ago, the United States ... continents. This study illuminates how American history and the ongoing ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 2NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 3NXT-ID Hires Master Pickpocket and Security Consultant Apollo Robbins for Wocket Smart Wallet CES 2015 Debut 423andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... in Pharmacology Why are menthol cigarettes ... more frequently, find it more difficult to quit smoking, and ... the effect of menthol is that it masks the harsh ... But Nadine Kabbani from George Mason University in ...
... commended the U.S. Food and Drug Administration, or FDA, today ... Food Safety Modernization Act. The first rule would require importers ... FDA safety standards. The second rule would establish standards to ... to help ensure that food imports are safe. Sandra Eskin, ...
... University have discovered a new way to join materials together ... heard is normally used to smash particles apart in ... by McGill professor Jake Barralet, from the faculties of Dentistry ... they could instead bond together into strong agglomerates, about the ...
Cached Biology News:Frontiers news briefs: July 23 2Frontiers news briefs: July 23 3Frontiers news briefs: July 23 4Quantum of sonics: Bonded, not stirred 2
(Date:1/22/2015)... Diagenode, Inc., a leading global ... and complete solutions for epigenetics research, recently launched ... the need for manual processing. The new ChIPettor ... of histones or transcription factors and a semi-automated ...
(Date:1/22/2015)... Jan. 22, 2015  Derma Sciences, Inc. (Nasdaq: ... on advanced wound care, announces that AMNIOEXCEL® and ... been added to the Premier, Inc. Regenerative Skin ... for the AMNIOEXCEL® and AMNIOMATRIX® product lines, which ...
(Date:12/24/2014)... BOTHELL, Wash. , Dec. 24, 2014   BioLife Solutions ... manufacturer and marketer of proprietary clinical grade hypothermic storage ... thermal shipping products for cells and tissues  ("BioLife" or ... Annual Meeting of Stockholders on May 4, 2015 (the "Annual ...
(Date:12/24/2014)... 23, 2014 On Friday, December 19, ... Omnibus and Continuing Resolution Appropriations Act of 2015, which ... to receive funding through the Congressionally Directed Medical Research ... The Hydrocephalus Association (HA), working in conjunction with its ...
Breaking Biology Technology:Diagenode Launches Unique Semi-Automated Solution for Chromatin Immunoprecipitation 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5BioLife Solutions Sets Date for Annual Meeting of Stockholders 2Rare Brain Condition Now Eligible for Department of Defense Research Dollars 2
... -- WuXi PharmaTech (NYSE:,WX), China,s leading provider ... announce today that its Chairman and Chief ... one of the 2007 China Top 10 ... (Logo: http://www.newscom.com/cgi-bin/prnh/20040705/CNM002LOGO ), The ...
... LLC, today announced the,first implantation of its proprietary InterPlate(TM) ... as an interbody device in September 2007. The,unique design ... RSB Spine has recently completed the national rollout of ... which is being very well,received by spine surgeons across ...
... Product Progresses in Phase 2 ... ... ), a biotechnology company focused on the development of,compounds for the treatment ... as senior vice president of research,and development. Dr. Taub brings extensive experience ...
Cached Biology Technology:WuXi PharmaTech (NYSE: WX) CEO Honored among the 2007 China Top 10 Influential Entrepreneurs 2WuXi PharmaTech (NYSE: WX) CEO Honored among the 2007 China Top 10 Influential Entrepreneurs 3RSB Spine, LLC Announces First Implantation of the InterPlate(TM) L for the Lumbar Spine 2VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 2VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 3VIA Pharmaceuticals Names Rebecca Taub Senior Vice President of Research and Development 4
pH-insensitive fluorescence (pH 2-12)...
PPOX Immunogen: PPOX (AAH02357, 378 a.a. ~ 478 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
KRIT1 Immunogen: KRIT1 (NP_004903, 637 a.a. ~ 737 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rabbit polyclonal to MAP3K12 ( Abpromise for all tested applications). Antigen: Synthetic peptide conjugated to KLH from the C-terminal region of human MAP3K12 Entrez Gene ID: 7786 Swiss ...
Biology Products: