Navigation Links
New malaria vaccine shows promise in early clinical trial

A malaria vaccine remains the most desired tool to combat the worsening malaria epidemic in many developing countries. Pierre Druilhe and colleagues (from the Institut Pasteur in Paris) have completed the first human trial of a vaccine based on MSP3, a protein present on the surface of the malaria parasite, with very encouraging results.

As the researchers report in the international open-access medical journal PLoS Medicine, most of the 30 healthy volunteers who received the vaccine developed strong, specific, and in some cases long-lasting immune responses against the MSP3 protein.

However, as researchers have learned from many early HIV and malaria vaccine trials, the crucial question is whether these immune responses mean that vaccinated people are actually protected against malaria. The straightforward way to test this is to expose the vaccinated trial participants to malaria and see if they are protected. However, this risky test is not ethical during the early stages of vaccine testing.

But Druilhe and colleagues were nevertheless able to take their early trial a step further: They demonstrated that antibodies from the blood of vaccinated volunteers were able to inhibit growth of the malaria parasite in two independent laboratory assays.

"A particular strength of the MSP3 trial is that functional assays [tests to see whether the vaccine could kill parasites] were utilized to assess the quality of the antibody response produced," say Brendan Crabb and James Beeson in an accompanying Perspective. However, they also point out that important questions remain, some of which will only be answered in additional clinical trials. Based on the results described in the PLoS Medicine article, Druilhe and colleagues have started a Phase II efficacy field trial of the MSP3 vaccine in malaria-exposed individuals.


'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Scientists reveal molecular secrets of the malaria parasite
2. Simple drug has the potential to save many lives threatened by malaria
3. Molecular models advance the fight against malaria
4. Reducing malarial transmission in Africa
5. Sickle cell and protection against malaria
6. Chemists synthesize molecule that helps body battle cancers, malaria
7. Gene expands malarias invasion options
8. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
9. Measuring hidden parasites in falciparum malaria
10. Old drug, new tricks: Prospects for slashing the impact of malaria
11. Researchers discover how malaria parasite disperses from red blood cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/18/2017)... -- Socionext Inc., a global expert in SoC-based imaging and computing solutions, ... which features the company,s hybrid codec technology. A demonstration utilizing TeraFaces ... will be showcased during the upcoming Medtec Japan at Tokyo Big ... Las Vegas Convention Center April 24-27. ... Click here for an image of ...
(Date:4/13/2017)... April 13, 2017 According to a new market ... Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, ... Market is expected to grow from USD 14.30 Billion in 2017 to ... of 17.3%. ... MarketsandMarkets Logo ...
(Date:4/11/2017)... April 11, 2017 No two people ... at the New York University Tandon School of ... have found that partial similarities between prints are ... in mobile phones and other electronic devices can ... The vulnerability lies in the fact that fingerprint-based ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... At its national board meeting ... I. Sheikh, the co-founder, CEO and chief research scientist of Minnesota-based Advanced Space ... membership in ARCS Alumni Hall of Fame . ASTER Labs is a ...
(Date:10/11/2017)... ... October 11, 2017 , ... Personal eye wash is a basic first aid supply ... a time. So which eye do you rinse first if a dangerous substance enters both ... Duo Eye Wash with its unique dual eye piece. , “Whether its dirt and ...
(Date:10/11/2017)... ... October 11, 2017 , ... Proscia Inc ... hosting a Webinar titled, “Pathology is going digital. Is your lab ready?” with ... adoption best practices and how Proscia improves lab economics and realizes an increase ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 ... London (ICR) and University of ... prognostic tool to risk-stratify patients with multiple myeloma (MM), in ... nine . The University of Leeds ... by Myeloma UK, and ICR will perform the testing services ...
Breaking Biology Technology: