Navigation Links
New malaria vaccine shows promise in early clinical trial

A malaria vaccine remains the most desired tool to combat the worsening malaria epidemic in many developing countries. Pierre Druilhe and colleagues (from the Institut Pasteur in Paris) have completed the first human trial of a vaccine based on MSP3, a protein present on the surface of the malaria parasite, with very encouraging results.

As the researchers report in the international open-access medical journal PLoS Medicine, most of the 30 healthy volunteers who received the vaccine developed strong, specific, and in some cases long-lasting immune responses against the MSP3 protein.

However, as researchers have learned from many early HIV and malaria vaccine trials, the crucial question is whether these immune responses mean that vaccinated people are actually protected against malaria. The straightforward way to test this is to expose the vaccinated trial participants to malaria and see if they are protected. However, this risky test is not ethical during the early stages of vaccine testing.

But Druilhe and colleagues were nevertheless able to take their early trial a step further: They demonstrated that antibodies from the blood of vaccinated volunteers were able to inhibit growth of the malaria parasite in two independent laboratory assays.

"A particular strength of the MSP3 trial is that functional assays [tests to see whether the vaccine could kill parasites] were utilized to assess the quality of the antibody response produced," say Brendan Crabb and James Beeson in an accompanying Perspective. However, they also point out that important questions remain, some of which will only be answered in additional clinical trials. Based on the results described in the PLoS Medicine article, Druilhe and colleagues have started a Phase II efficacy field trial of the MSP3 vaccine in malaria-exposed individuals.


'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Scientists reveal molecular secrets of the malaria parasite
2. Simple drug has the potential to save many lives threatened by malaria
3. Molecular models advance the fight against malaria
4. Reducing malarial transmission in Africa
5. Sickle cell and protection against malaria
6. Chemists synthesize molecule that helps body battle cancers, malaria
7. Gene expands malarias invasion options
8. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
9. Measuring hidden parasites in falciparum malaria
10. Old drug, new tricks: Prospects for slashing the impact of malaria
11. Researchers discover how malaria parasite disperses from red blood cells
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New malaria vaccine shows promise early clinical trial

(Date:7/30/2014)... Wallerian degeneration is a subject of major interest ... differentially regulated during the distinct stages of Wallerian ... differentiation and dedifferentiation. Although gene expression responses in ... peripheral nerve injury are known, differences in gene ... unclear. Dr. Dengbing Yao and co-workers from Nantong ...
(Date:7/30/2014)... the roughly 3,000 pieces is still in its infant ... will be of major significance. "Amazingly often, we are ... Fushun amber that we found in Baltic amber," explained ... Baltic amber comes from the Baltic Sea region, which ... finds are, e.g., the coastal regions of Mecklenburg, Poland ...
(Date:7/29/2014)... of Bristol,s Nutrition and Behaviour Unit (NBU) has looked ... planning meals. , The research, to be presented at ... (SSIB 2014) in Seattle, USA this week [29 July ... team was led by Professor Jeff Brunstrom, and is ... part of a Biotechnology and Biological Sciences Research Council ...
Breaking Biology News(10 mins):Chinese mosquitos on the Baltic Sea 2
... continues to reduce its carbon footprint through enhanced sustainability ... efforts have been crucial to the university,s recent recognition ... Colleges." UH has been recognized as a green university ... "UH is thrilled to be recognized again by The ...
... Botanic Gardens, Kew (RBG Kew), the Royal Botanic Garden ... the Missouri Botanical Garden (MBG), have announced plans to ... the world,s plantsto be made available by the year ... information on up to 400,000 plant species worldwide. It ...
... they were the ultimate survivors. They successfully negotiated three ... end of the Cretaceous along with the dinosaurs: Ammonoids, ... cephalopods believed to be related to today,s squid and ... the course of evolution. However, what was once a ...
Cached Biology News:UH makes Princeton Review's Green List 3 years in a row 2Botanical institutions announce plans to create first online World Flora 2Botanical institutions announce plans to create first online World Flora 3First fruitful, then futile: Ammonites or the boon and bane of many offspring 2
(Date:7/30/2014)... , July 30, 2014  AtheroNova Inc. (OTCBB: ... and development of compounds to safely regress atherosclerotic ... announces that its partner, CardioNova, has accomplished first ... trial with AtheroNova,s lead compound, AHRO-001.  This Phase ... AHRO-001 Phase 1 safety trial completed in February ...
(Date:7/30/2014)... July 30, 2014 Adding to their ... weighing boat special – Buy 2 of any ... promotion will benefit lab technicians looking for durable and ... are ideal for multiple applications including weighing liquids, solid, ... of choices including diamond-shaped, hexagonal, square, aluminum weighing, and ...
(Date:7/29/2014)... have hurdled a number of significant technological challenges ... observing technology originally created for the James Webb ... Investigator Harvey Moseley, a scientist at NASA,s Goddard ... that electrostatically actuated microshutter arrays that is, ... are as functional as the current technology,s magnetically ...
(Date:7/29/2014)... 2014) Tough, ultralight foam of atom-thick sheets can ... chemical process invented at Rice University. , In ... nanoscale building, with floors and walls that reinforce each ... materials: floors and walls of graphene oxide that self-assemble ... , The researchers say the foam could find use ...
Breaking Biology Technology:AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 2AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 3AtheroNova Announces Milestone with Initiation of Phase 1b Clinical Trial of AHRO-001 4Weighing Boat Promotion Now Available at Pipette.com, Major Pipette Distributor 2Revolutionary microshutter technology hurdles significant challenges 2Revolutionary microshutter technology hurdles significant challenges 3Revolutionary microshutter technology hurdles significant challenges 4Tough foam from tiny sheets 2
... Formulation and CHO cGMP Media Library for Cell Culture ... a business segment within SAFC(R), a member of the ... that it has expanded its portfolio of products and ... line applications with the introduction of EX-CELL(TM) CD ...
... 8 Advanced Life Sciences Holdings, Inc. (Nasdaq: ... novel once-a-day antibiotic, to treat respiratory tract infections and ... filed a shelf registration statement on Form S-3 with ... and when the shelf registration statement is declared effective ...
... guide designed to help consulting engineers and ... environmentsBUFFALO GROVE, Ill., April 8 Siemens ... Life Science Solutions Design Guide written expressly ... are looking to design and specify effective ...
Cached Biology Technology:SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 2SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 3SAFC Biosciences(R) Expands Media Capability for Chinese Hamster Ovary (CHO) Cell Lines 4Advanced Life Sciences Announces Filing of Shelf Registration Statement 2Advanced Life Sciences Announces Filing of Shelf Registration Statement 3Siemens Offers Life Science Solutions Design Guide for Consulting Engineers 2
Mouse monoclonal antibody raised against a full length recombinant GPT. NCBI Entrez Gene ID = GPT...
Mouse monoclonal antibody raised against a partial recombinant TPR. NCBI Entrez Gene ID = TPR...
... Each kit contains sufficient materials for 1,464 array sample ... Membrane: 4 each , Blocker BSA in PBS (10X): ... BupH Phosphate Buffered Saline: 8 packs , 10% Tween-20: ... Luminol Enhancer: 2 x 25 ml , SuperSignal West ...
... 100-120 V, is used for biolistic particle ... device employs an adjustable helium pulse to ... microcarriers from the inner wall of a ... This system has a 2 square-centimeter target ...
Biology Products: