Navigation Links
New malaria vaccine shows promise in early clinical trial

A malaria vaccine remains the most desired tool to combat the worsening malaria epidemic in many developing countries. Pierre Druilhe and colleagues (from the Institut Pasteur in Paris) have completed the first human trial of a vaccine based on MSP3, a protein present on the surface of the malaria parasite, with very encouraging results.

As the researchers report in the international open-access medical journal PLoS Medicine, most of the 30 healthy volunteers who received the vaccine developed strong, specific, and in some cases long-lasting immune responses against the MSP3 protein.

However, as researchers have learned from many early HIV and malaria vaccine trials, the crucial question is whether these immune responses mean that vaccinated people are actually protected against malaria. The straightforward way to test this is to expose the vaccinated trial participants to malaria and see if they are protected. However, this risky test is not ethical during the early stages of vaccine testing.

But Druilhe and colleagues were nevertheless able to take their early trial a step further: They demonstrated that antibodies from the blood of vaccinated volunteers were able to inhibit growth of the malaria parasite in two independent laboratory assays.

"A particular strength of the MSP3 trial is that functional assays [tests to see whether the vaccine could kill parasites] were utilized to assess the quality of the antibody response produced," say Brendan Crabb and James Beeson in an accompanying Perspective. However, they also point out that important questions remain, some of which will only be answered in additional clinical trials. Based on the results described in the PLoS Medicine article, Druilhe and colleagues have started a Phase II efficacy field trial of the MSP3 vaccine in malaria-exposed individuals.


'"/>

Source:Public Library of Science


Page: 1

Related biology news :

1. Scientists reveal molecular secrets of the malaria parasite
2. Simple drug has the potential to save many lives threatened by malaria
3. Molecular models advance the fight against malaria
4. Reducing malarial transmission in Africa
5. Sickle cell and protection against malaria
6. Chemists synthesize molecule that helps body battle cancers, malaria
7. Gene expands malarias invasion options
8. University of Nevada, Reno research team discovers hormone that causes malaria mosquito to urinate
9. Measuring hidden parasites in falciparum malaria
10. Old drug, new tricks: Prospects for slashing the impact of malaria
11. Researchers discover how malaria parasite disperses from red blood cells
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/17/2017)... -- NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or ... 2016 Annual Report on Form 10-K on Thursday April 13, 2017 ... ... Investor Relations section of the Company,s website at http://www.nxt-id.com  under ... http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... , Apr. 11, 2017 Research and ... Market 2017-2021" report to their offering. ... The global eye tracking market to grow at a ... report, Global Eye Tracking Market 2017-2021, has been prepared based on ... covers the market landscape and its growth prospects over the coming ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
Breaking Biology News(10 mins):
(Date:5/18/2017)... ... 17, 2017 , ... NDA Partners Chairman Carl Peck, MD , announced ... Laboratories and President of Pharmaceutical Development Business Unit of Cardinal Health, has joined the ... Health, he was former Chief Operating Officer at Anaborex, Senior VP and General Manager ...
(Date:5/18/2017)... ... May 17, 2017 , ... Cognition Corporation ( ... just released version 9.0 of the Cognition Cockpit platform. , “Our whole team ... David Cronin, CEO of Cognition. “We’re thrilled to finally be able to release ...
(Date:5/18/2017)... Mo. (PRWEB) , ... May 17, 2017 , ... ... vessels and equipment for varying industries, including food and dairy, munitions, and pharmaceutical/biotech, ... optimal operator safety and ease of use. The improvement in technology comes on ...
(Date:5/18/2017)... ... 2017 , ... Many complicated neurological disorders appear to have ... while men are at greater risk for Parkinson’s disease. Understanding some of the ... of a research program at Worcester Polytechnic Institute (WPI) funded by a new ...
Breaking Biology Technology: