Navigation Links
New light microscope sharpens scientists' focus

where one protein is located is nice," Betzig said, "but what you really want to know is where multiple proteins are in relation to one another." The researchers are now exploring the use of additional labeling molecules, to ultimately enable scientists to get a molecular level view of how proteins interact with one another inside cells.

These are the interactions that drive cellular activity, and watching them in action will be important to understanding the interface between molecular and cellular biology. "As the PALM technology advances, it may prove to be a key factor in unlocking at the molecular level secrets of intracellular dynamics that are unattainable by other methods," observed Davidson, who directs the optical microscopy division at FSU.

The researchers also acknowledge that the time needed to collect the thousands of single molecule images that go into each PALM picture is cumbersome. With the camera snapping one to two pictures each second, it can take two to 12 hours to image a single sample. Activating more molecules per frame would reduce the number images that must be collected, and making the molecules brighter would reduce the time needed to take each image. Either would help to speed the PALM process ?a high priority for the Hess and Betzig as they continue to refine the technique.

The two inventors are eager to continue developing their technique into something that is practical for use by biologists -- a process that they anticipate will be easier when they and their microscope move to the Janelia Farm campus in the coming months. "I think we've come a long way in the last year, from two unemployed guys with just an idea to having good jobs and a good set of data," Betzig noted. "Now if we can begin to refine this technique, we should really be able to take it to a lot of new applications."


'"/>

Source:Howard Hughes Medical Institute


Page: 1 2 3 4 5 6

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Recent breakthroughs in common adult leukemia highlighted in New England Journal of Medicine
3. Bacteria collection sheds light on urinary tract infections
4. Sea skate experiment sheds light on human cell transport
5. X-Ray Beams And Fruit Fly Flight Simulator Aid Scientists View Of Muscle Power
6. McGill researchers shed light on formation of carcinogen in food
7. Scientists discover how plants disarm the toxic effects of excessive sunlight
8. Medical molecules designed to respond to visible light that can penetrate tissue
9. Genetic defects give the immune system the green light to attack the pancreas
10. Researchers find gene that may be at root of potato blight
11. Remote control flies? Fly behavior controlled by laser light

Post Your Comments:
(Date:11/4/2009)...4 GenVault Corporation (Carlsbad, ...., has joined its Board of Directors. Dr. Brody, ...stitute, is an acclaimed physician-scientist and u...tute, Dr. Brody served as president of The Johns H... Academy of Engineering and the Institute of Medic...
(Date:11/3/2009)...ultimate loner of the ocean, cruising thousands of...rs has discovered that the sharks have maintained ...ens of thousands of years the white sharks in the ...es into a population genetically distinct from sha...a large, highly mobile species," said Salvador Jor...
(Date:11/3/2009)...Ind. - Chief executives in 35 of the top Fortune 5...r "ideal salaries" in 2008, according to a new typ...versity researcher to determine fair CEO compensat...rporate governance issues of the day is how to det...nkatasubramanian, a professor of chemical engineer...
Breaking Biology News(10 mins):Dr. William Brody, President of the Salk Institute for Biological Studies, Appointed to GenVault's Board of Directors 2Dr. William Brody, President of the Salk Institute for Biological Studies, Appointed to GenVault's Board of Directors 3Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers 2Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers 3Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers 4New theory on fairness in economics targets CEO pay 2New theory on fairness in economics targets CEO pay 3New theory on fairness in economics targets CEO pay 4Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 1Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 2Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 3Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 4Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 5Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 6Catalyst Pharmaceutical Partners Reports Second Quarter 2009 Financial Results 13447 7NeurogesX Reports Second Quarter 2009 Results 13446 1NeurogesX Reports Second Quarter 2009 Results 13446 2NeurogesX Reports Second Quarter 2009 Results 13446 3NeurogesX Reports Second Quarter 2009 Results 13446 4NeurogesX Reports Second Quarter 2009 Results 13446 5NeurogesX Reports Second Quarter 2009 Results 13446 6NeurogesX Reports Second Quarter 2009 Results 13446 7NeurogesX Reports Second Quarter 2009 Results 13446 8NeurogesX Reports Second Quarter 2009 Results 13446 9NeurogesX Reports Second Quarter 2009 Results 13446 10NeurogesX Reports Second Quarter 2009 Results 13446 11NeurogesX Reports Second Quarter 2009 Results 13446 12Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 1Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 2Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 3Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 4Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 5Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 6Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 7Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 8Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 9Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 10Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 11Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 12Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 13Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 14Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 15Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 16Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 17Warner Chilcott Reports Operating Results for the Quarter Ended June 30 2009 and Updates 2009 Full Year Guidance 53933 18
... Cancer Research at the University of California, ...rkable property of the contractile ring, a structu...the contractile ring works to divide the cell may ...ontrolled cell division in cancer. , The researc...he length of the contractile ring are reduced duri...
...iety (ACerS) announced today that it is launching ...edicated to glass research: The International Jou...enerations of glass and glass-related materials ar... many of the world,s emerging technologies, includ... environmental, optical and defense technologies s...
.... , In the context of the climatic change of th... global warming are of great interest. That is the...pension of solid or liquid particles on a gaseous ...cooling of the atmosphere. , Juan Luis Guerrero ...nique for atmospheric characterization by elastic ...
Other Biology News:Study may aid efforts to prevent uncontrolled cell division in cancer 2New journal on advanced glass research to debut 2A research work will be the reference to characterize the climatic impact of desert dust 2
(Date:11/5/2009)... Brooke Sanders brings a new look to Pro R... November 5, 2009 -- Professional Reprographics, O... company is pleased to present Brooke Sanders to t...hics/PR specialist. The addition of Brooke to the ... within Professional Reprographics., , ,Brooke bri...
(Date:11/4/2009)... The Human Anthrax Vaccine Program must be...the feature film "A Call to Arms:2009 Edition...ot;Fatal Immunity: The Human Anthrax Vaccine Story...esent danger of top secret government science turn...accountability to its victims. It is available fo...
(Date:11/4/2009)... Va., Nov. 4 Star Scie...at the company plans to introduce the CigRx(TM) nu...ock Creek Pharmaceuticals, for worldwide marketing...Inc . (Nasdaq: VTIV). inVentiv Health offers a c...very stage of the product lifecycle, in a range of...
(Date:11/4/2009)... Calif., Nov. 4 Onyx Pha...d that it will present at the Credit Suisse 18th A... 11, at 9:30 a.m. Mountain Time (8:30 a.m. Pacific...ast of the presentation on our website at: http:...,, It is recommended that listeners log on 15 m...
Breaking Biology Technology:Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 2Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 3Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 4Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 5Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 6Scott Miller's 'A Call To Arms' And 'Fatal Immunity' Are Available For World-Wide Licensing 7Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 2Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 3Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 4
...UT CREEK, CAGenomics is accelerating improvements ...ernative to fossil fuel for the nation,s transport....S. Department of Energy Joint Genome Institute (D...Nature . In "Genomics of cellulosic biofuels," Ru...ic technologies will contribute to a substantially...
...SON Electronic devices get smaller and more compl...price for miniaturization, especially when it come...he floor. Wouldn,t it be great if they bounced ins... University researchers, led by Apparao Rao, profe...f tiny, shock-absorbing carbon springs which possi...
...ON, Mass., Aug. 13 Indevus,Pharmaceuticals, Inc. ....S.,Patent No. 7,410,978 (the ",978 patent"), enti...is licensed exclusively to the Company by the pate...e ,978 patent covers the Company,s approved produc...spium chloride which is indicated for the,treatmen...
Other Biology Technology:DOE JGI Director Eddy Rubin highlights the genomics of plant-based biofuels in the journal Nature 2DOE JGI Director Eddy Rubin highlights the genomics of plant-based biofuels in the journal Nature 3DOE JGI Director Eddy Rubin highlights the genomics of plant-based biofuels in the journal Nature 4Clemson scientists put a (nano) spring in their step 2Indevus Pharmaceuticals Announces Issuance of U.S. Patent for SANCTURA XR(TM) 2Indevus Pharmaceuticals Announces Issuance of U.S. Patent for SANCTURA XR(TM) 3
GIBCO Streptomycin Sulfate from Invitrogen
GIBCO Dulbeccos Modified Eagle Medium (D-MEM) (1X); powder (low glucose) from Invitrogen
Goat Anti-Adducin beta (C-16) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.
Rat TNF-alpha ELISA Kit, OptEIA from BD Biosciences Pharmingen
Biology Products: