Navigation Links
New lifespan extension genes found

New genes tied to lifespan extension in yeast have been identified by researchers from UC Davis and Harvard Medical School.

Drastically reducing calorie intake, or caloric restriction, is known to extend the lifespan of species including yeast, worms and rodents. Previous research linked a gene called Sir2 with lifespan extension due to caloric restriction, but worms and yeast that lack Sir2 also live longer when put on a tough diet, showing that some other genes must be at work.

Researchers led by David Sinclair at Harvard Medical School and Su-Ju Lin at UC Davis' Center for Genetics and Development and Section of Microbiology screened for other life-extending genes in yeast. They found a gene called Hst2 that accounts for most of the difference.

Deleting Hst2 and Sir2 blocked most of the beneficial effect of caloric restriction. When Hst2 was overexpressed, so that the gene was more active than normal, the yeast lived longer than normal. A third gene, Hst1, appears to act when both Sir2 and Hst2 are missing.

Sir2 and the newly identified Hst genes account for all of the life-prolonging effects of caloric restriction in yeast, Lin said.

In yeast, the effects of aging seem to be due to a build-up of toxic circular DNA molecules that accidentally get copied out of ribosomal DNA, an unstable area of the yeast genome that contains hundreds of repeated sequences.

The researchers showed that caloric restriction drastically reduces recombination of ribosomal DNA, and that deleting Hst2 and Sir2 blocks this effect.

Very similar genes are found in widely different animals including worms, flies and rodents. But the targets of these genes are likely to be different, as the toxic DNA circles have not been identified in more advanced organisms, Lin said.

The work was published in the Sept. 16 issue of Science.


'"/>

Source:University of California - Davis


Page: 1

Related biology news :

1. Researchers extend mouse lifespan by protecting against free radicals
2. MicroRNA gene that regulates lifespan found by Yale scientists
3. Fish evolve a longer lifespan by evolving a longer reproductive period, researchers find
4. Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate
5. New research says winning a Nobel Prize adds nearly 2 years to your lifespan
6. Researchers find link between food odors and lifespan in fruit flies
7. Growth factor stimulates rapid extension of key motor neurons in brain
8. Newly-discovered class of genes determines ?and restricts ?stem cell fate
9. Inexpensive, mass-produced genes core of synthetic biology advances at UH
10. First atlas of key brain genes could speed research on cancer, neurological diseases
11. U-M scientists find genes that control growth of common skin cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/26/2016)... , April 27, 2016 ... the  "Global Multi-modal Biometrics Market 2016-2020"  report to ... ) , The analysts forecast the ... CAGR of 15.49% during the period 2016-2020.  ... number of sectors such as the healthcare, BFSI, ...
(Date:4/13/2016)... April 13, 2016  IMPOWER physicians supporting Medicaid patients ... a new clinical standard in telehealth thanks to a ... the higi platform, IMPOWER patients can routinely track key ... body mass index, and, when they opt in, share ... visit to a local retail location at no cost. ...
(Date:3/22/2016)... March 22, 2016 ... Sensors Market for Consumer Industry by Type (Image, ... Application (Communication & IT, Entertainment, Home Appliances, ... Forecast to 2022", published by MarketsandMarkets, the ... to reach USD 26.76 Billion by 2022, ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Supplyframe, the Industry ... Supplyframe Design Lab . Located in Pasadena, Calif., the Design Lab’s mission ... hardware projects are designed, built and brought to market. , The Design Lab ...
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... -- On Wednesday, June 22, 2016, the NASDAQ ... Dow Jones Industrial Average edged 0.27% lower to finish at ... Stock-Callers.com has initiated coverage on the following equities: Infinity Pharmaceuticals ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ... Learn more about these stocks by accessing their free trade ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, a ... designed, tuned and optimized exclusively for Okuma CNC machining centers at The International ... a collaboration among several companies with expertise in toolholding, cutting tools, machining dynamics ...
Breaking Biology Technology: