Navigation Links
New lifespan extension genes found

New genes tied to lifespan extension in yeast have been identified by researchers from UC Davis and Harvard Medical School.

Drastically reducing calorie intake, or caloric restriction, is known to extend the lifespan of species including yeast, worms and rodents. Previous research linked a gene called Sir2 with lifespan extension due to caloric restriction, but worms and yeast that lack Sir2 also live longer when put on a tough diet, showing that some other genes must be at work.

Researchers led by David Sinclair at Harvard Medical School and Su-Ju Lin at UC Davis' Center for Genetics and Development and Section of Microbiology screened for other life-extending genes in yeast. They found a gene called Hst2 that accounts for most of the difference.

Deleting Hst2 and Sir2 blocked most of the beneficial effect of caloric restriction. When Hst2 was overexpressed, so that the gene was more active than normal, the yeast lived longer than normal. A third gene, Hst1, appears to act when both Sir2 and Hst2 are missing.

Sir2 and the newly identified Hst genes account for all of the life-prolonging effects of caloric restriction in yeast, Lin said.

In yeast, the effects of aging seem to be due to a build-up of toxic circular DNA molecules that accidentally get copied out of ribosomal DNA, an unstable area of the yeast genome that contains hundreds of repeated sequences.

The researchers showed that caloric restriction drastically reduces recombination of ribosomal DNA, and that deleting Hst2 and Sir2 blocks this effect.

Very similar genes are found in widely different animals including worms, flies and rodents. But the targets of these genes are likely to be different, as the toxic DNA circles have not been identified in more advanced organisms, Lin said.

The work was published in the Sept. 16 issue of Science.


'"/>

Source:University of California - Davis


Page: 1

Related biology news :

1. Researchers extend mouse lifespan by protecting against free radicals
2. MicroRNA gene that regulates lifespan found by Yale scientists
3. Fish evolve a longer lifespan by evolving a longer reproductive period, researchers find
4. Resveratrol prolongs lifespan and delays onset of aging-related traits in a short-lived vertebrate
5. New research says winning a Nobel Prize adds nearly 2 years to your lifespan
6. Researchers find link between food odors and lifespan in fruit flies
7. Growth factor stimulates rapid extension of key motor neurons in brain
8. Newly-discovered class of genes determines ?and restricts ?stem cell fate
9. Inexpensive, mass-produced genes core of synthetic biology advances at UH
10. First atlas of key brain genes could speed research on cancer, neurological diseases
11. U-M scientists find genes that control growth of common skin cancer
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/7/2017)... BEACH, New York , February 7, 2017 /PRNewswire/ ... known as ID Global Solutions Corporation [OTC: IDGS], ("Ipsidy" ... identity management and electronic transaction processing services, is pleased ... reorganization of the Company. Effective January 31, ... of the Board of Directors, CEO and President.  An ...
(Date:2/2/2017)... , Feb. 2, 2017  EyeLock LLC, a market ... new white paper " What You Should Know About ... of ensuring user authenticity is a growing concern. In ... of users. However, traditional authentication schemes such as username/password ... Biometric authentication offers an elegant solution to the ...
(Date:1/26/2017)... Jan. 26, 2017  Crossmatch, a leading provider of ... solution aimed at combatting fraud, waste and abuse in ... at the Action on Disaster Relief conference in ... for UN agencies and foreign assistance organizations throughout ... and abuse are a largely unacknowledged problem in the ...
Breaking Biology News(10 mins):
(Date:2/16/2017)... Calif. , Feb. 16, 2017  ArmaGen, ... developing groundbreaking therapies to treat severe neurological disorders, ... children treated with AGT-181, the company,s investigational therapy ... (also known as mucopolysaccharidosis type I, or MPS ... 2 proof-of-concept (POC) study, presented today at the ...
(Date:2/16/2017)... , Feb. 16, 2017   Biostage, Inc. ... "Company"), a biotechnology company developing bioengineered organ implants to ... bronchus and trachea, announced today the closing on February ... 20,000,000 shares of common stock and warrants to purchase ... of $8.0 million. The offering was priced at $0.40 ...
(Date:2/16/2017)... , Feb. 16, 2017  Dermata Therapeutics, ... products to treat a variety of dermatological diseases, ... Series 1a financing and entered into a $5 ...  Dermata intends to use the capital for general ... major advancements in the treatment of serious diseases ...
(Date:2/16/2017)...  Windtree Therapeutics, Inc. (Nasdaq: WINT ... KL4 surfactant therapies for respiratory diseases, announced today ... that aerosolized KL4 surfactant reduced lung inflammation and ... model. The Company believes that these preclinical data ... supports the role of KL4 surfactant as a ...
Breaking Biology Technology: