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New lead reported in tumor angiogenesis

not been well studied.

After further laboratory and mouse experiments, Wang said the data supported their hypothesis. "Over the past several years, various compounds have been developed to inhibit secreted proteins such as the much-studied vascular endothelial growth factor, or VEGF, which clearly plays a role in tumor angiogenesis," said Wang. "To date, though, none of these compounds have been very effective as cancer therapies, suggesting that other factors may play a role. We think that we have found one of these additional factors."

Zeng added that because the research involved cells from head and neck tumors, the discovery could provide further insight into the uniquely invasive character of these cancers. He explained that cells in head and neck tumors tend to be mobile, shifting within the developing mass and possibly establishing tumor-to-endothelial cell contact to prompt angiogenesis. "We have some evidence that inflammatory factors, and even some infectious agents, can induce jagged1 expression," said Wang. "That's what we plan to study next."

The article is titled, "Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling." The article was published in the July issue of Cancer Cell, and its authors are: Qinghua Zeng, Shenglin Li, Douglas B. Chepeha, Jong Li, Honglai Zhang, Peter J. Polverini, Jacques Nor, Jan Kitajewski, and Cun-Yu Wang.


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Source:NIH


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