Navigation Links
New lead reported in tumor angiogenesis

Scientists supported by the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health, have added a key new piece to the puzzle of how tumor cells induce new blood vessels to form and fuel their abnormal growth, a well-known process called angiogenesis.

As published in this month's issue of the journal Cancer Cell, the scientists found that in addition to the well-known strategy of secreting proteins to trigger angiogenesis, tumor cells also physically attach to a protein displayed on the surfaces of cells that line the walls of our blood vessels. This physical interaction, like a finger pushing a button, sends a signal within these cells to grow and sprout new capillaries.

The finding, while technical in nature, has potentially major implications for anti-angiogenic therapy, one of the hottest areas in cancer research. Dr. Cun-Yu Wang, a scientist at the University of Michigan and senior author on the paper, said the finding suggests a future anti-angiogenic strategy of blocking not only the secreted molecules but also the cell-to-cell contact.

Wang said these early data also suggest the intriguing possibility of directing growth-inhibiting drugs at the normal blood vessel cells to stop angiogenesis. "It's well established that tumor cells can become resistant to chemotherapy," said Dr. Wang. "For endothelial cells, which are the cells that line the walls of the blood vessels, there is no indication that resistance is a problem. It's an intriguing idea, and one that we think might be well worth pursuing."

This month's paper, as is often the case in the world of science, involves a great deal of hard work - and a little luck. Wang said his group began a few years ago studying a secreted protein called hepatocyte growth factor, or HGF, and its role in helping head and neck tumors to turn cancerous. HGF does so, in part, by helping to induce nearby blood vessels to grow misguidedly toward a
'"/>

Source:NIH


Page: 1 2 3

Related biology news :

1. Surprising findings reported about iron overload
2. Loss of a universal tRNA feature reported
3. DNA analysis suggests under-reported kills of threatened whales
4. Mouse brain tumors mimic those in human genetic disorder
5. Researchers add new tool to tumor-treatment arsenal
6. Self-assembled nano-sized probes allow Penn researchers to see tumors through flesh and skin
7. Pulsating ultrasound enhances gene therapy for tumors
8. Scientists identify molecule that regulates well-known tumor suppressor
9. New tumor-suppressor gene discovered
10. NSAID drug protects against intestinal tumors in mice, despite poor diet and gene losses
11. Natural tumor suppressor in body discovered by UCSD medical researchers
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New lead reported tumor angiogenesis

(Date:5/24/2013)... studying noise in one French Quarter neighborhood of New ... municipal ordinances, Annette Hurley, PhD, Assistant Professor of Audiology ... Arriaga, a third-year LSUHSC doctor of audiology student, recommend ... hearing health. Their case study is published online in ... Management ., "An important part of an audiologist,s practice ...
(Date:5/23/2013)... , Automated conserved noncoding sequence (CNS) discovery ... grasses , Within the genome of each species, ... little change in position and sequence over millions of ... of these evolutionarily stable sequences, so-called conserved noncoding sequences ... genes or the condensation of chromosomes, but the function ...
(Date:5/23/2013)... per year, carrying more than 284 million tons of cargo, ... dollars in toll fees for the Panama Canal Authority. Each ... of water are used from Gatun Lake, which is also ... in the isthmus. , However, the advent of very ... the ships at sea, has demanded change. The Panama Canal ...
Breaking Biology News(10 mins):Please do try this at home 2Frontiers news briefs: May 23 2Frontiers news briefs: May 23 3Reforestation study shows trade-offs between water, carbon and timber 2Reforestation study shows trade-offs between water, carbon and timber 3
... control everything of importance in biology. The genome rules all ... realizing that among the diverse forms of RNA, a kind ... other and with genes directly to manage the genome from ... by the vast stretches of DNA that do not code ...
... in a gene known as SOS1 account for many ... disorder which occurs in one in 1,000-2,500 live births. ... and learning disabilities, as well as heart problems and ... at Harvard Medical School-Partners Healthcare Center for Genetics ...
... on a person's ability to recover from a heart ... Nuclear Medicine. , "Using positron emission tomography (PET) and ... study the regenerative capacity of the heart's sympathetic nervous ... develop new nerves to replace damaged ones--is slower in ...
Cached Biology News:Peering into the shadow world of RNA 2Peering into the shadow world of RNA 3Study uncovers mutation responsible for Noonan Syndrome 2Diabetes slows nerve recovery after heart transplant 2
(Date:5/23/2013)... Can economic incentives such as gift ... of the public to increase their donations of blood? ... Carey Business School Assistant Professor Mario Macis says ... large body of recent research that supports their argument, ... issue of Science that the World Health Organization and ...
(Date:5/23/2013)...  Rahal Letterman Lanigan Racing (RLL) and StemCyte, Inc., ... banking and therapeutics, announced today that StemCyte has become ... Indy car driven by James Jakes ... IndyCar 2013 season.   StemCyte, Inc. and Rahal ... of umbilical cord blood banking and its educational initiative ...
(Date:5/23/2013)... HILLS, Calif. , May 23, 2013  Saddleback ... recently became the first hospital on the ... robotic technology. This new surgical option provides women with ... Marc Winter , M.D., ... gynecologist and surgeon and medical director of minimally invasive ...
(Date:5/23/2013)... , May 23, 2013 Z Trim Holdings, ... ingredients to a variety of industries, announced that Chef ... panel discussion at this year,s National Restaurant Association ("NRA") ... on behalf of the Research Chefs Association.  Chef Ryan ... The Good, the Bad and the Ugly," joining four ...
Breaking Biology Technology:Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 2Offering Economic Incentives to Attract Blood Donations Should Be Encouraged, Research Team writes in Science 3StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 2StemCyte, Inc. Joins Rahal Letterman Lanigan Racing As Associate Sponsor Of No. 16 IndyCar Program For James Jakes Beginning With The 97th Indianapolis 500 3Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 2Saddleback Memorial Surgeon First on the West Coast to Perform Single-Site Robotic Hysterectomy 3Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 2Z Trim's Chef Erin Ryan sits on Expert Panel at NRA Show 3
... Oct. 31 ThermoGenesis,Corp. (Nasdaq: KOOL ), a ... stem cells, announced today it will report,financial results for ... November 6, 2008., Company,s Conference Call and Webcast, ... 6, 2008 at,2:00 PM Pacific (5:00 PM Eastern) to ...
... Corp. (OTC,Bulletin Board: SCOM) ("Sharps" or the "Company"), ... quantity generators of medical,waste, today announced the appointment ... Chief Operating Officer, effective October 27,2008. Mr. Grow, ... Board of Directors,since October of 2005, will retain ...
... Oct. 31 LI-COR Biosciences now offers,the LI-COR ... blot washing,and secondary antibody addition for Western blots. ... or multiple blots, the,LI-COR Blot Washer is an ... user-defined, preset wash cycles. Up to 20 presets ...
Cached Biology Technology:ThermoGenesis Corp. to Announce First Quarter Fiscal 2009 Results on November 6, 2008 2Sharps Compliance Corp. Announces Appointment of John R. Grow as President and Chief Operating Officer 2Sharps Compliance Corp. Announces Appointment of John R. Grow as President and Chief Operating Officer 3LI-COR Blot Washer Automates Western Blot Processing 2
... Transcend Non-Radioactive Translation Detection Systems allow ... vitro. Using these systems, biotinylated lysine ... during translation, eliminating the need for ... amino acids. This biotinylated lysine is ...
...
... value of your microarray data using ... support you need from consultation to ... up to date methods. Utilize our ... Expression Profiling Service or from your ...
... the value of your microarray data using ... you need from consultation to extensive data ... methods. Utilize our expertise in combination with ... your own microarray experiments., ,Normalization and basic ...
Biology Products: