Navigation Links
New lab technique churns out fungus' potential cancer fighter

For the first time, researchers have developed a way to synthesize a cancer-killing compound called rasfonin in enough quantity to learn how it works.

Derived from a fungus discovered clinging to the walls of a New Zealand cave, the chemical tricks certain cancer cells into suicide while leaving healthy cells untouched.

"In 2000, scientists in Japan discovered that this compound might have some tremendous potential as a prototype anticancer agent, but no one has been able to study or develop it because it's so hard to get enough of it from natural sources," says Robert K. Boeckman, professor of chemistry.

"You either grow the fungus that makes it, or you go through a complicated chemical synthesis process that still yields only a minute amount," he says. "Now, after five years of effort, we've worked out a process that lets researchers finally produce enough rasfonin to really start investigating how it functions, and how we might harness it to fight cancer."

In 2000, researchers from Chiba University in Japan and the University of Tokyo simultaneously discovered a compound in certain fungi that selectively destroyed cells depending upon a gene called ras--one of the first known cancer-causing genes. They had found rasfonin, a compound that seemed tailor-made to knock out ras-dependent cancers like pancreatic cancer.

After six years, however, rasfonin's secrets remain a mystery because researchers can't make enough of it to carry out tests.

To bring about a new drug, organic chemists must produce a new chemical in enough quantity to test it under many different circumstances to tease out its modus operandi. Until now, no method existed to generate rasfonin, aside from growing more fungus--a time-consuming and terribly inefficient method.Boeckman, the Marshall D. Gates, Jr. Professor of Chemistry at the University of Rochester, has now revealed a process that produces 67 times more rasfonin than any previous method. For
'"/>

Source:University of Rochester


Page: 1 2

Related biology news :

1. New lab technique identifies high levels of pathogens in therapy pool
2. Brain-mapping technique aids understanding of sleep, wakefulness
3. Study reveals new technique for fingerprinting environmental samples
4. Researchers pioneer new gene therapy technique using natural repair process
5. Newer imaging techniques may lead to over-treatment
6. Gene silencing technique offers new strategy for treating, curing disease
7. Mosaic mouse technique offers a powerful new tool to study diseases and genetics
8. Researchers devise new technique for creating human stem cells
9. New technique rapidly detects illness-causing bacteria
10. New bioinformatics technique for systematically analyzing key regions in DNA that help control gene activity
11. New technique may speed DNA analysis
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New lab technique churns out fungus potential cancer fighter

(Date:11/4/2014)... Temple University School of Medicine announced today that ... initiative funded by the Bill & Melinda Gates ... Obstetrics, Gynecology and Reproductive Sciences; and Vice Chair ... School of Medicine will pursue an innovative global ... Biomarkers to Assess Fetal Neurodevelopment.", Grand Challenges Explorations ...
(Date:11/4/2014)... England , November 4, 2014 ... and vertical market growth   Fuel3D , ... has closed a funding round totaling $6.4 million (£4 million). ... million) funding secured earlier this year and paves the way ... in 2015. The funding round was led by ...
(Date:11/3/2014)... DUBLIN , Nov. 3, 2014 Research ... report "Cell Therapy - Technologies, Markets and Companies" ... evaluates cell therapy technologies and methods, which have already started ... Hematopoietic stem cell transplantation is replacing the old fashioned bone ... described. Cell therapy is bound to become a part of ...
Breaking Biology News(10 mins):Temple University School of Medicine receives Grand Challenges Explorations grant 2Fuel3D Secures $6.4 Million in Expansion Funding 2Fuel3D Secures $6.4 Million in Expansion Funding 3Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 2Global Cell Therapy - Technologies, Markets and Companies: 2014 Report 3
... indicates that wild salmon may account for just 10 ... vast majority of the fish come from hatcheries. The ... decline in the population this year, which will probably ... and recreational salmon fishing. The role of ...
... 15 years of biodiversity and climate change research ... announced formation of its Asia Center to forge ... use of environmental resources. One of the first ... Philadelphia, is with Nanjing University, one of the ...
... Inzana, the Tyler J. and Frances F. Young Professor ... Pathobiology in the Virginia-Maryland Regional College of Veterinary Medicine ... the United States Department of Agriculture to study the ... Disease Complex (BRDC). The $374,000 grant will allow ...
Cached Biology News:Hatchery fish outnumber wild chinook salmon in troubled fall run 2Hatchery fish outnumber wild chinook salmon in troubled fall run 3Hatchery fish outnumber wild chinook salmon in troubled fall run 4Hatchery fish outnumber wild chinook salmon in troubled fall run 5Academy establishes Asia Center to protect the environment 2Academy establishes Asia Center to protect the environment 3Academy establishes Asia Center to protect the environment 4Veterinary college researchers explore function of biofilm in bovine respiratory disease 2
(Date:11/24/2014)... Senior Vice President, General Manager for Clinical ... acumen Elsevier , a world-leading provider ... congratulates Diane Bartoli , Senior Vice President and ... Solutions, for being recognized in the 13 th ... Profiles in Diversity Journal ® . ...
(Date:11/22/2014)... 2014 Two new educational webinars hosted by ... for ALS research and how the pharmaceutical industry can make ... Bucket Challenge: Where Does the ALS Money Go? , Featuring ... 2014, Time: 1:30pm ET, Register to attend , ... Merit Cudkowicz, Julianne Dorn Professor of Neurology at Massachusetts General ...
(Date:11/22/2014)... Prominent academics, leaders of the ... December 3rd at Genetic Rx, a networking conference ... take place at the Joseph B. Martin Conference ... the present and future of genetic medicines—including siRNA, ... editing—as well as the treatment of patients with ...
(Date:11/22/2014)... (PRWEB) November 21, 2014 RURO, ... solutions provider, has released Limfinity® version 5.1.4. , ... projects of Limfinity® than ever in RURO’s 8 ... and minority framework enhancement. Limfinity® version 5.1.4 is ... above and beyond bug fixes! , Limfinity® 5.1.4 ...
Breaking Biology Technology:Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 2Elsevier Clinical Solutions' Diane Bartoli Featured In Profiles in Diversity Journal's 13th Annual Women Worth Watching Issue 3DrugDev Webinars in December to Explore What Comes Next for ALS Research and How We Can Make Life Easier for Clinical Sites 2Pioneering Academics and Key Industry Leaders to Discuss Rare Diseases and the Emergence of New Genetic Medicines at Genetic Rx on December 3rd 2RURO Announces Limfinity® version 5.1.4 2
... /PRNewswire-FirstCall/ - The Board of Directors of,Neptune ... decided,not to re-price any options including the ... directors., About Neptune Technologies, Neptune ... for nutraceutical and pharmaceutical applications and is,sponsoring ...
... Trusted LASIK Surgeons launched its revolutionary Trusted LASIK Surgeons ... order to provide a resource for consumers seeking to ... directory apart is a unique screening process ensuring that ... Eye Surgery, Laser Surgeons in the United States are ...
... Shareholders to Reject Entire Management,Slate of InSite Vision, ... AUSTIN, Texas and HOUSTON, Sept. 11 PTV ... firm, is pleased to,announce that RiskMetrics Group -(Formerly ... corporate governance firm, recommended that the,stockholders of InSite ...
Cached Biology Technology:Neptune Technologies decided not to re-price options 2Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 2Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 3Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 4Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 5Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 6Trusted LASIK Surgeons Welcomes Leading LASIK Eye Surgery Expert, Inventor David Huang, M.D., Los Angeles, to Its Unique Lasik Directory Service 7RiskMetrics (ISS), An Independent Proxy Advisory Firm, Recommends Voting the GOLD Card for Four of PTV's Nominees: Anderson, McInerney, Melrose, and O'Holla 2RiskMetrics (ISS), An Independent Proxy Advisory Firm, Recommends Voting the GOLD Card for Four of PTV's Nominees: Anderson, McInerney, Melrose, and O'Holla 3RiskMetrics (ISS), An Independent Proxy Advisory Firm, Recommends Voting the GOLD Card for Four of PTV's Nominees: Anderson, McInerney, Melrose, and O'Holla 4
... The enzyme glycerol 3-phosphate dehydrogenase ... phosphate (DHAP) and glycerol 3-phosphate, with ... increases significantly during differentiation of progenitor ... activity of this enzyme has been ...
... with an Affinity Chitin-binding Tag) utilizes the ... elements (termed inteins) to purify recombinant proteins ... 1 and 2). This system distinguishes itself ... ability to separate a recombinant protein from ...
... pET Host Strain Competent Cell Sets ... optimizing vector/host strain combinations The ... into E. coli is to ... can be prepared in the laboratory, greater ...
... EZ DNA Methylation Kit uses a simplified ... DNA methylation analysis. The kit is based ... place between cytosine and sodium bisulfite where ... DNA Methylation Kits innovative in-column desulphonation reaction ...
Biology Products: