Navigation Links
New insights into the software of life

A series of discoveries by an international consortium of scientists, including a team from The University of Queensland's Institute for Molecular Bioscience (IMB), will transform our understanding of how our genome works to produce a complex organism like a human being.

The findings of the consortium 'FANTOM', led by the Genomic Sciences Center, RIKEN Yokohama Institute and Genome Science Laboratory and RIKEN Wako Institute, will be published today in two papers in the prestigious journal Science.

Spokesman for the IMB team Professor David Hume, who has been a member of the FANTOM consortium for the past 5 years, and a senior author on both papers, said the massive data sets produced by the consortium, which were on the same scale as the completion of the human genome sequence, provided the scientific community with the tools to understand the control of protein production, truly the software of life.

"Genes provide the code for making the building blocks of our bodies - the proteins ?and the consortium has a made a massive step towards identifying all of those building blocks. But the genome must also contain the code to ensure that protein building blocks are made in the right place at the right time.

"The new data provides several indications of the molecular basis of evolution and why we are so much more complex than the simple worm, despite the fact that we only have a small number of additional conventional genes.

"In simple terms, the data shows that in mammals each individual gene uses multiple different mechanisms to produce different forms of protein. In a sense, each 'gene' is actually multiple different genes," Professor Hume explained.

The second of the papers in Science deals extensively with another area to which the IMB team has made a major contribution; outputs of the genome (RNAs) that do not code for protein.

IMB Director Professor John Mattick, co-author of these papers, has predicte d the importance of non-coding RNA in development and evolution in a series of papers published internationally over the past five years, including an article published in this same issue of Science entitled Functional genomics of non-coding RNA.

"I congratulate all IMB staff and students involved in this research collaboration, particularly David Hume who has been pivotal in developing the IMB's partnership with RIKEN over several years."

As part of the collaboration with RIKEN, Professor Hume's group has recently been awarded a grant from RIKEN to continue the translation of this work into the next phase, the Human Genome network project.


Source:Research Australia

Related biology news :

1. New insights into how Huntingtons disease attacks the brain
2. Marsupial genome reveals insights into mammalian evolution
3. Frog’s ear canal may provide insights for understanding human hearing loss
4. New insights into neural tube defects
5. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
6. AIDS vaccine research offers new insights on survival
7. Mutant mouse provides insights into breast cancer
8. From hot springs to rice farms, scientists reveal new insights into the secret lives of archaea
9. New insights into autoimmunity and depression
10. UWs Rosetta software to unlock secrets of many human proteins
11. GeneNotes - A novel information management software for biologists
Post Your Comments:

(Date:10/29/2015)... 29, 2015 Today, LifeBEAM , ... with 2XU, a global leader in technical performance ... hat with advanced bio-sensing technology. The hat will ... monitor key biometrics to improve overall training performance. ... two companies will bring together the most advanced technology, ...
(Date:10/26/2015)... India , October 26, 2015 ... --> adds ... 2015 to 2021 as well as ... 2015-2019 research reports to its collection ... . --> ...
(Date:10/23/2015)... , October 23, 2015 ... announce a mobile plug and play integration of physiological ... tasks SensoMotoric Instruments (SMI) present a ... solutions for eye tracking and physiological data registration. It ... SMI Eye Tracking Glasses 2w and physiological signals ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 /CNW/ - iCo Therapeutics ("iCo" ... reported financial results for the quarter ended September ... in Canadian dollars and presented under International Financial ... States ," said Andrew Rae , ... regarding iCo-008 are not only value enriching for ...
(Date:11/24/2015)... ... November 24, 2015 , ... International Society ... one of the premier annual events for pharmaceutical manufacturing: 2015 Annual Meeting. The ... where ISPE hosted the largest number of attendees in more than a decade. ...
(Date:11/24/2015)... N.C. , Nov. 24, 2015  Clintrax Global, Inc., a ... North Carolina , today announced that the company has set ... represented a 391% quarter on quarter growth posted for Q3 of ... and Mexico , with the establishment ... in December 2015. --> United Kingdom ...
(Date:11/24/2015)... ... 24, 2015 , ... This fall, global software solutions leader SAP and AdVenture ... develop and pitch their BIG ideas to improve health and wellness in their schools. ... to win the title of SAP's Teen Innovator, an all-expenses paid trip to Super ...
Breaking Biology Technology: