Navigation Links
New insights into neural tube defects

Environmental and genetic factors lead to neural tube defects in 1 in every 1,000 births and cause 1 in 20 of every spontaneous abortion. One cause of these defects is the failure of cells within the neural tube to migrate to the middle of the developing neural tube.

A study in this week's issue of Nature is the first to report on the molecular mechanism that directs cells to migrate to the correct local within the developing neural tube of vertebrates.

Marek Mlodzik, PhD, Professor, Molecular, Cell and Development Biology at Mount Sinai School of Medicine has previously reported that the asymmetrical distribution of specific proteins within neural tissues in fruit flies controls the orientation and migration of cells.

Working with colleagues Brian Ciruna, Diana Lee, and Alexander Schier, who were at New York University when the research was conducted, and Andreas Jenny of Mount Sinai, Dr. Mlodzik's and Dr. Schier's laboratories have now found that a similar mechanism is at work in vertebrates.

During cell division the polarity of a cell is lost. Therefore, the newly formed daughter cells initially lack the information to direct them to migrate to the midline where they are needed for proper neural tube development. The report in Nature is the first to demonstrate that the polarity is restored to the daughter cells after rather than during cell division and to provide the specific molecules involved in restoring polarity.

After cell division, proteins that direct the polarity of the cell distribute asymmetrically. This distribution restores polarity in the daughter cell, directing them to migrate to the midline of the neural tube.


'"/>

Source:The Mount Sinai Hospital / Mount Sinai School of Medicine


Page: 1

Related biology news :

1. New insights into how Huntingtons disease attacks the brain
2. New insights into the software of life
3. Marsupial genome reveals insights into mammalian evolution
4. Frog’s ear canal may provide insights for understanding human hearing loss
5. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
6. AIDS vaccine research offers new insights on survival
7. Mutant mouse provides insights into breast cancer
8. From hot springs to rice farms, scientists reveal new insights into the secret lives of archaea
9. New insights into autoimmunity and depression
10. Gene keeps neural cells on correct developmental path
11. Researchers discover stem cell guide that may be key for targeting neural stem cell treatments
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/22/2016)... June 22, 2016 On Monday, the Department ... industry to share solutions for the Biometric Exit Program. ... and Border Protection (CBP), explains that CBP intends to ... the United States , in order ... defeat imposters. Logo - http://photos.prnewswire.com/prnh/20160622/382209LOGO ...
(Date:6/20/2016)... June 20, 2016 Securus Technologies, a ... solutions for public safety, investigation, corrections and monitoring ... involved, it has secured the final acceptance by ... for Managed Access Systems (MAS) installed. Furthermore, Securus ... to be installed by October, 2016. MAS distinguishes ...
(Date:6/15/2016)... York , June 15, 2016 ... new market report titled "Gesture Recognition Market by Application ... Forecast, 2016 - 2024". According to the report, the  ... 11.60 billion in 2015 and is estimated to ... USD 48.56 billion by 2024.  Increasing ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... NEW YORK , June, 23, 2016  The ... students to envision new ways to harness living systems ... of Modern Art (MoMA) in New York ... more than 130 participating students, showcased projects at MoMA,s ... included Paola Antonelli , MoMA,s senior curator of ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
(Date:6/23/2016)... NEWPORT BEACH, Calif. , June 23, 2016 /PRNewswire/ ... offering new biological discoveries to the medical community, has ... and co-founder Matthew Nunez . "We ... provide us with the capital we need to meet ... funding will essentially provide us the runway to complete ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only free validated ... will showcase its product’s latest features from June 26 to June 30, 2016 ... on Disrupting Clinical Trials in The Cloud during the conference. DIA (Drug ...
Breaking Biology Technology: