Navigation Links
New insights into neural tube defects

Environmental and genetic factors lead to neural tube defects in 1 in every 1,000 births and cause 1 in 20 of every spontaneous abortion. One cause of these defects is the failure of cells within the neural tube to migrate to the middle of the developing neural tube.

A study in this week's issue of Nature is the first to report on the molecular mechanism that directs cells to migrate to the correct local within the developing neural tube of vertebrates.

Marek Mlodzik, PhD, Professor, Molecular, Cell and Development Biology at Mount Sinai School of Medicine has previously reported that the asymmetrical distribution of specific proteins within neural tissues in fruit flies controls the orientation and migration of cells.

Working with colleagues Brian Ciruna, Diana Lee, and Alexander Schier, who were at New York University when the research was conducted, and Andreas Jenny of Mount Sinai, Dr. Mlodzik's and Dr. Schier's laboratories have now found that a similar mechanism is at work in vertebrates.

During cell division the polarity of a cell is lost. Therefore, the newly formed daughter cells initially lack the information to direct them to migrate to the midline where they are needed for proper neural tube development. The report in Nature is the first to demonstrate that the polarity is restored to the daughter cells after rather than during cell division and to provide the specific molecules involved in restoring polarity.

After cell division, proteins that direct the polarity of the cell distribute asymmetrically. This distribution restores polarity in the daughter cell, directing them to migrate to the midline of the neural tube.


'"/>

Source:The Mount Sinai Hospital / Mount Sinai School of Medicine


Page: 1

Related biology news :

1. New insights into how Huntingtons disease attacks the brain
2. New insights into the software of life
3. Marsupial genome reveals insights into mammalian evolution
4. Frog’s ear canal may provide insights for understanding human hearing loss
5. Engineered heart tissue offers insights into irregular heartbeats, defibrillator failure
6. AIDS vaccine research offers new insights on survival
7. Mutant mouse provides insights into breast cancer
8. From hot springs to rice farms, scientists reveal new insights into the secret lives of archaea
9. New insights into autoimmunity and depression
10. Gene keeps neural cells on correct developmental path
11. Researchers discover stem cell guide that may be key for targeting neural stem cell treatments
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insights into neural tube defects

(Date:3/23/2015)... ANGELES , March 23, 2015  In the ... Federal fraud case conviction losses. This figure accounts for ... which, according to The Nilson Report, exceeds $11 billion ... investigative tool after a crime has occurred. Investor ... and polygraph expert Joe Paolella partnered to ...
(Date:3/20/2015)... Mar. 19, 2015 Research and Markets ( ... Geometry - Global Strategic Business Report" report to their ... Hand Geometry in US$ Thousands. The report provides separate comprehensive ... Japan , Europe , ... and Rest of World. Annual estimates and forecasts ...
(Date:3/19/2015)... 2015  NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... growing mobile commerce market, announces its biometric payment technology, the ... aired this week on Washington DC,s ... a segment "The Next Great Thing", host Laura Evans ... pay, and ,a really big breakthrough in mobile payment.,  ...
Breaking Biology News(10 mins):Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 2NXT-ID's Wocket Smart Wallet Featured on Fox News Segment, "The Next Great Thing" 3
... incidence and severity of allergic asthma in early life, according ... published today in the journal EMBO reports , shows ... profound impact on allergic asthma. "It has long ... those in developed countries are more prone to allergic ...
... zones known as marine protected areas provide many direct ... such zones appear to offer limited help to corals ... new study. To protect coral reefs from climate ... policies that can meaningfully reduce greenhouse gas emissions, researchers ...
... Biophysics professors at Western University, in London, Canada, have developed ... a desk. Jerry Battista, Chair of the Department of ... and Kevin Jordan of the London Regional Cancer Program at ... as a novel and interactive way to teach CT imaging ...
Cached Biology News:Exposure to antibiotics linked to severity of allergic asthma: UBC research 2Rising ocean temperatures harm protected coral reefs 2Rising ocean temperatures harm protected coral reefs 3Mini-CT scanner developed as a teaching tool 2
(Date:4/17/2015)... , April 17, 2015  Centrillion ... a SBIR grant from the National Human ... Institutes of Health (NIH). The grant will ... in the development of breakthrough genomic technologies, ... specially fabricated substrates. Centrillion has been developing ...
(Date:4/17/2015)... -- Guggenheim Securities, the investment banking and capital markets division ... William Tanner as a Managing Director and senior ... work at Guggenheim in May 2015 in the firm,s ... "Bill brings a wealth of biotech experience, in both ... acclaimed healthcare team," said Matthew Johnson , Senior ...
(Date:4/17/2015)... BellBrook Labs announced today that they ... powerful Orthogonal Pooled Screening (OPS) Platform developed and ... Lankenau Institute for Medical Research (LCGC) in Wynnewood, ... successful drug discovery outcomes using far more efficient ... available nowhere else, coupled to a state-of-the-art compound ...
(Date:4/16/2015)... CA (PRWEB) April 16, 2015 Cytokinetics, ... to report first quarter results on Thursday, April 30, ... Cytokinetics’ senior management will host a conference call at ... results and the company’s outlook for the future. , ... be accessed from the homepage and in the Investor ...
Breaking Biology Technology:Guggenheim Securities Hires Biotech Analyst William Tanner in Expansion of Healthcare Coverage 2BellBrook Labs and Lankenau Institute Partner to Accelerate Drug Discovery using Orthogonal Pooled Screening 2Cytokinetics to Announce First Quarter Results on April 30, 2015 2Cytokinetics to Announce First Quarter Results on April 30, 2015 3
... institute on Monday in Milwaukee. Milwaukee ... southeastern Wisconsin is the goal behind the formation of ... a $1 million grant from the University of ... Health Technologies is intended to foster more cooperation between ...
... help to explain Wisconsin's efforts to compete in a ... in Milwaukee, Hewlett-Packard vice president Kevin Gilroy said the ... to stand out in the crowd. The worldwide "digital ... capital are no longer barriers to entry in business. ...
... (PDS) has hired a new vice president as it plans ... , ,The company which maintains offices in Oconomowoc, Brookfield ... services for medium-sized and large organizations. Austin Park, the company's ... restructuring his group and bringing it new focus. , ,Park, ...
Cached Biology Technology:New biomedical institute aims to unite business and academia in SE Wisconsin 2New biomedical institute aims to unite business and academia in SE Wisconsin 3New biomedical institute aims to unite business and academia in SE Wisconsin 4In an increasingly 'flat' world, Wisconsin must adapt to compete 2In an increasingly 'flat' world, Wisconsin must adapt to compete 3
delta-like 1 homolog (Drosophila)...
...
... mutS are mismatch repair minus strains of ... repair of the newly synthesized unmethylated strand ... making them helpful in such systems as ... Systems. Both ES1301 and BMH 71-18 mutS ...
Polaroid black & white positive, 3 x 4 inch pack film, ISO 3000/ 36 ASA DIN (20 expsures). For use in the Polaroid Direct Copy Camera (PHC34)....
Biology Products: