Navigation Links
New insight into regulation of blood stem cells

Scientists have made a significant advance toward understanding the regulation of blood stem cells and the complex, lifelong process of blood cell formation. A research study published in the February issue of Developmental Cell expands on previous studies by using adult animals to examine the role of a key gene known to be required for blood cell formation. Information gained from this research will be useful for future studies aimed at directing stem cell differentiation in a variety of potential therapeutic contexts.

Blood cell formation, known as hematopoiesis, begins with a hematopoietic stem cell (HSC), which can either "self-renew" and make more copies of itself or differentiate into either red blood cells, various types of white blood cells, or platelets. The genes that control proliferation and differentiation have been difficult to study using traditional gene disruption methods because loss of genes thought to be critical for this process often results in embryonic death, making it impossible to study the role of the gene of interest in mature animals.

Dr. Michael P. Cooke and colleagues from the Genomics Institute of the Novartis Research Foundation in San Diego found a way around this problem. The researchers used random mutagenesis and screening to find animals with hematopoiesis defects, and they used genetics to identify the causative gene. One line mapped to a mutation in the gene c-Myb, which has a known role in regulation of blood formation.

Interestingly, they found that c-Myb is not required for every step of hematopoiesis or for every type of blood cell. Instead, c-Myb is critical for very distinct steps in the formation of specific types of blood cells. Most surprisingly, the c-Myb mutants also had a dramatic increase in the total number of HSCs, suggesting that part of the normal function of c-Myb is to hold HSC multiplication in check.

These data suggest that c-Myb is a key regulator of hematopoiesis and acts a t many distinct points to control HSCs. "It is remarkable that a single transcription factor controls the diverse processes of self-renewal, proliferation, and differentiation" says Dr. Cooke. "The next challenge is to understand how c-Myb controls HSC numbers and use this information to develop compounds that can regulate stem cell proliferation and differentiation. The ability to influence stem cell fate decisions would be expected to have a major impact on the field of stem cell therapy and to provide important in vitro model systems for the identification of genes and compounds that can be used to regulate the process of stem cell differentiation."


'"/>

Source:Cell Press


Related biology news :

1. New insight into people who see colors in letters and numbers
2. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
3. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
4. New insights into how Huntingtons disease attacks the brain
5. Gambling monkeys give insight into neural machinery of risk
6. Structures of marine toxins provide insight into their effectiveness as cancer drugs
7. Flies on speed offer insight into the roles of dopamine in sleep and arousal
8. Grasshopper love songs give insight into sensory tuning
9. Studies on human genome variation provide insight into disease
10. Study provides insight into cellular defenses against genetic mutation
11. New insights into the software of life
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... SEATTLE , April 5, 2017  The Allen ... the Allen Cell Explorer: a one-of-a-kind portal and dynamic ... large-scale 3D imaging data, the first application of deep ... edited human stem cell lines and a growing suite ... the platform for these and future publicly available resources ...
(Date:4/5/2017)... 2017 KEY FINDINGS The global ... a CAGR of 25.76% during the forecast period of ... factor for the growth of the stem cell market. ... MARKET INSIGHTS The global stem cell market is ... geography. The stem cell market of the product is ...
(Date:4/3/2017)...  Data captured by IsoCode, IsoPlexis Corporation,s ... statistically significant association between the potency of ... objective response of cancer patients post-treatment. The ... cancer patients will respond to CAR-T cell ... to improve both pre-infusion potency testing and cell ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... Iowa (PRWEB) , ... October 12, 2017 , ... ... based in Vilnius, Lithuania, announced today that they have entered into a multiyear ... is to provide CRISPR researchers with additional tools for gene editing across all ...
(Date:10/12/2017)... ... 2017 , ... AMRI, a global contract research, development and ... outcomes and quality of life, will now be offering its impurity solutions as ... regulatory requirements for all new drug products, including the finalization of ICH M7 ...
(Date:10/11/2017)... ... October 11, 2017 , ... The CRISPR-Cas9 system ... experiments and avoiding the use of exogenous expression plasmids. The simplicity of programming ... systematic gain-of-function studies. , This complement to loss-of-function studies, such as with ...
(Date:10/11/2017)... ... 11, 2017 , ... Proscia Inc ., a data ... titled, “Pathology is going digital. Is your lab ready?” with Dr. Nicolas Cacciabeve, ... and how Proscia improves lab economics and realizes an increase in diagnostic confidence.* ...
Breaking Biology Technology: