Navigation Links
New insight into regulation of blood stem cells

Scientists have made a significant advance toward understanding the regulation of blood stem cells and the complex, lifelong process of blood cell formation. A research study published in the February issue of Developmental Cell expands on previous studies by using adult animals to examine the role of a key gene known to be required for blood cell formation. Information gained from this research will be useful for future studies aimed at directing stem cell differentiation in a variety of potential therapeutic contexts.

Blood cell formation, known as hematopoiesis, begins with a hematopoietic stem cell (HSC), which can either "self-renew" and make more copies of itself or differentiate into either red blood cells, various types of white blood cells, or platelets. The genes that control proliferation and differentiation have been difficult to study using traditional gene disruption methods because loss of genes thought to be critical for this process often results in embryonic death, making it impossible to study the role of the gene of interest in mature animals.

Dr. Michael P. Cooke and colleagues from the Genomics Institute of the Novartis Research Foundation in San Diego found a way around this problem. The researchers used random mutagenesis and screening to find animals with hematopoiesis defects, and they used genetics to identify the causative gene. One line mapped to a mutation in the gene c-Myb, which has a known role in regulation of blood formation.

Interestingly, they found that c-Myb is not required for every step of hematopoiesis or for every type of blood cell. Instead, c-Myb is critical for very distinct steps in the formation of specific types of blood cells. Most surprisingly, the c-Myb mutants also had a dramatic increase in the total number of HSCs, suggesting that part of the normal function of c-Myb is to hold HSC multiplication in check.

These data suggest that c-Myb is a key regulator of hematopoiesis and acts a
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. New insight into people who see colors in letters and numbers
2. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
3. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
4. New insights into how Huntingtons disease attacks the brain
5. Gambling monkeys give insight into neural machinery of risk
6. Structures of marine toxins provide insight into their effectiveness as cancer drugs
7. Flies on speed offer insight into the roles of dopamine in sleep and arousal
8. Grasshopper love songs give insight into sensory tuning
9. Studies on human genome variation provide insight into disease
10. Study provides insight into cellular defenses against genetic mutation
11. New insights into the software of life
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insight into regulation blood stem cells

(Date:7/23/2015)... Research and Markets ( http://www.researchandmarkets.com/research/rzzp3v/global_outlook_of ) ... Outlook of the Biometrics Industry 2015 " ... global biometrics market is likely to witness significant ... to the uptake of multiple technologies available. The ... the growth of biometrics in existing applications as ...
(Date:7/20/2015)... DENVER , July 20, 2015  Acuity ... Mobility Report: The Convergence of Commerce and Privacy" ... billion mobile biometric apps will be downloaded to ... users. The mobile biometrics market is projected to ... app revenue during the seven-year forecast period.    ...
(Date:7/9/2015)... , July 07, 2015 ... the addition of the "Biometrics for Banking; ... 2015-2020" report to their offering. ... contributor to this growth and the forecast is ... in revenue for companies involved in delivering biometric ...
Breaking Biology News(10 mins):Global Outlook of the Biometrics Industry 2015 2Global Outlook of the Biometrics Industry 2015 3Biometrics on Smart Mobile Devices to Redefine Digital Identity with 12.9 Billion Biometric App Downloads between 2014 and 2020 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 2Global Banking Biometrics Market 2015-2020 - Market & Technology Analysis, Adoption Strategies and Forecasts 3
... very fatty beans from which oil is refined into biodiesel in ... University of Southern Denmark along with researchers from Brazil have succeeded ... be possible to alter the bean,s structure in order to get ... however shows that this may not be an easy task. ...
... researchers has used next generation sequencing to identify ... pediatric speech disorder. The findings are published in ... Journal of Neurodevelopmental Disorders http://www.jneurodevdisorders.com/content/5/1/29 . ... rare, severe speech disorder that in some patients ...
... special issue of the International Journal of Global Warming ... loss and damage from the perspective of affected people in ... how climatic stressors affect communities, what measures households take to ... they are unable to adjust sufficiently. The guest-editors, Kees ...
Cached Biology News:Proteins in one of the world's main biodiesel plants have been mapped -- and it does not look good 2Loss and damage from climate change 2Loss and damage from climate change 3
(Date:7/27/2015)... ... July 27, 2015 , ... BlueInGreen® announced the addition of ... bring the world’s most efficient gas dissolution technology to all of Florida, excluding ... the industrial and municipal markets. With offices located in Sarasota, Sebring and Melbourne ...
(Date:7/27/2015)... ... 27, 2015 , ... Visual Assay was named as a finalist for the ... technologies and services of the past year. More than 70 judges selected the finalists, ... will be announced at the 2015 R&D 100 Awards Dinner on November 13 at ...
(Date:7/24/2015)... -- Equity Research Institute has initiated coverage ... PDLI ), Arena Pharmaceuticals Inc. (NASDAQ: ARNA ), ... (NASDAQ: NWBO ), and Acorda Therapeutics Inc. (NASDAQ: ... can be accessed at https://www.EquityResearchInstitute.com/reports?keyword=PDLI On Thursday, ... down 0.49%, the Dow Jones Industrial Average declined 0.67%, ...
(Date:7/24/2015)... 24, 2015 , Adds integrated ... Expands product offering for chronic kidney disease and oncology ... diabetes-related complications and dermatology , Increases group revenue ... or ,the Company"), a leading China ... marketing biopharmaceutical products, today announced that it has acquired ...
Breaking Biology Technology:BlueInGreen Brings Water Treatment Technology to Florida 2Visual Assay® Named Finalist in 53rd Annual R&D 100 Awards 2Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 2Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 3Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 4Biotechnology Stocks in Motion -- PDL BioPharma, Arena Pharma, StemCells, Northwest Biotherapeutics, and Acorda Therapeutics 53SBio Acquires Zhejiang Wansheng Pharmaceutical 23SBio Acquires Zhejiang Wansheng Pharmaceutical 33SBio Acquires Zhejiang Wansheng Pharmaceutical 4
... of global climate change and population growth call for sweeping ... warns a group of prestigious scientists, including an expert in ... research team, led by Nina Federoff, science and technology adviser ... a "critical need to get beyond popular biases against the ...
... process that produces both n-type and p-type doping ... the promising material for future electronic devices. ... increase conductivity in graphene nanoribbons used for interconnects. ... to graphene and then exposing it to electron-beam ...
... , CINCINNATI , Feb. 11 Kendle ... quarter and full-year 2009 financial results after the market closes on ... call and simultaneous webcast on Thursday, Feb. 25 at ... , Conference Call Instructions , To participate in the ...
Cached Biology Technology:Dramatic changes in agriculture needed as world warms and grows, researchers say 2Single-step technique produces both p-type and n-type doping for future graphene devices 2Single-step technique produces both p-type and n-type doping for future graphene devices 3Kendle Announces Details Regarding Fourth Quarter and Full-Year 2009 Earnings Conference Call and Webcast 2Kendle Announces Details Regarding Fourth Quarter and Full-Year 2009 Earnings Conference Call and Webcast 3