Navigation Links
New insight into machinery of immune cells' 'tentacles'

Researchers have identified new molecular components of the machinery that regulates formation of the tentacle-like filaments by which immune system T cells grasp other cells. This embrace by such filaments is critical for the T cell to establish communication with cells called "antigen presenting cells" (APCs). Such communication enables the T cell to program itself to target invading microbes for destruction. Antigens are proteins in invading microbes that the immune system detects to trigger a counterattack.

The researchers said their findings of the machinery of formation of such "actin filaments" could offer targets for drugs to induce the immune system to work more effectively to fight infection; or to damp its stimulation in autoimmune disease.

Led by Duke University Medical Center pharmacologist Ann Marie Pendergast, the researchers published their findings in the Jan. 10, 2006, issue of Current Biology. The research was sponsored by the National Institutes of Health. Another paper in the same issue -- by Daniel Billadeau and colleagues of the Mayo Clinic College of Medicine -- confirmed the Duke researchers' findings and also implicated the same machinery in regulating calcium mobilization in T cells.

In their studies, Pendergast and her colleagues sought to discover the signaling proteins in T cells responsible for formation, or polymerization, of the protein actin into filaments following activation of the T cells. Such actin filament formation is crucial for the T cell to attach to APCs, called B cells, which collect and display foreign proteins from invading microbes.

The ensuing "conversation" between T and B cells enables the T cell to effectively identify and target such invaders for destruction. The site of contact between the T and B cells has been dubbed the "immunological synapse," because it is a communication link between the cells just as synapses between brain cells are the sites where one brain cell signals ano
'"/>

Source:Duke University Medical Center


Page: 1 2 3

Related biology news :

1. New insight into people who see colors in letters and numbers
2. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
3. New insight into regulation of blood stem cells
4. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
5. New insights into how Huntingtons disease attacks the brain
6. Gambling monkeys give insight into neural machinery of risk
7. Structures of marine toxins provide insight into their effectiveness as cancer drugs
8. Flies on speed offer insight into the roles of dopamine in sleep and arousal
9. Grasshopper love songs give insight into sensory tuning
10. Studies on human genome variation provide insight into disease
11. Study provides insight into cellular defenses against genetic mutation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New insight into machinery immune cells tentacles

(Date:12/3/2014)... -- As part of our commitment to offering the ... announce the release of a new reader that will ... data that they need. The Atlas 2000 ... readers. Many such devices have serious shortcomings when it ... models force users to navigate numerous complicated steps in ...
(Date:11/21/2014)... 2014 Strict laws against distracted driving and ... North American and European automotive sector towards gesture recognition ... systems that are intuitive and able to retrieve information ... New analysis from Frost & Sullivan,s ... Europe and North ...
(Date:11/18/2014)... Nov. 18, 2014  The Secure Identity & ... today jointly announce the formation of The Airport ... its Identity and Biometric Entry and Exit ... received official support from BORDERPOL, the international non-profit ... and provide expertise regarding border security, traveler and ...
Breaking Biology News(10 mins):Inception Technologies to Release New Biometric Reader 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 2Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 3Gesture Recognition Intensifies with the Rise of In-car Smartphone Integration, Says Frost & Sullivan 4Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... Leatherback turtles are remarkably versatile divers. Routinely diving ... known to plunge as deep as 1250m. The animals ... prey and avoid heat in the tropics. However it ... as they plunge down. Sabrina Fossette from Swansea University ...
... Tinkering with a single gene may give perennial grasses more ... according to researchers at the Duke Institute for Genome Sciences ... are important biofuels crops and can be harvested repeatedly, just ... Center for Systems Biology. But before that can happen, the ...
... S.C. Environmental scientists at Clemson University have received ... of Energy to study how plutonium, a byproduct of ... has implications for nuclear cleanup efforts and could help ... posed by long-term nuclear waste disposal. "Plutonium contamination ...
Cached Biology News:How diving leatherback turtles regulate buoyancy 2Gene discovery suggests way to engineer fast-growing plants 2Clemson researcher will study plutonium underground for Energy Department 2
(Date:12/24/2014)... , Dec. 24, 2014 PlasmaTech Biopharmaceuticals, ... care in critical areas, announced the closing of an ... and warrants to purchase up to an aggregate 3,500,000 ... $4.00 per share and $.01 per warrant.  The warrants ... exercisable immediately, and expire 5 years from the date ...
(Date:12/24/2014)... “Preparative & Process Chromatography Market by Instrument (Liquid ... Valves, Guages, Seals), Accessories, Services, End User (Biotechnology, ... provides a detailed overview of the major drivers, ... impacting the preparative and process chromatography market along ... and share analysis. , Full Copy of ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... series is designed to introduce cutting edge ... users and partners of platform upgrades. This ... benefits; empowering users in their quest to ... tools. , According to SoundConnect’s Marketing Manager, ...
(Date:12/24/2014)... December 23, 2014 The ... such as its definition, classification, application and ... specification, manufacturing process, and product cost structure. ... applications. The analysis also covers upstream raw ... industry development trend and proposals. In the ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 2PlasmaTech Biopharmaceuticals, Inc. Announces Closing of Public Offering 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 2Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 3Preparative and Process Chromatography Market is expected to reach $9 billion by 2019 - New Report by Marketsandmarkets 4SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2
... March 7, 2012 Karyopharm Therapeutics Inc., a leader ... nine presentations covering its Selective Inhibitors of Nuclear Export ... meeting on March 31 – April 4, 2012, in ... studying the use of Karyopharm,s novel SINE, along with ...
... Inc. (OTC/BB: PROT) announced today that it has ... to which the Company has agreed to sell shares ... aggregate purchase price of approximately $3.8 million (which are ... common stock) and Series A, Series B and Series ...
... NEW YORK, March 5, 2012  Organovo, Inc., (OTCQB: ... on using its breakthrough NovoGen 3D human tissue ... research and medical applications, today announced that their ... on-demand viewing. LINK:    www.retailinvestorconferences.com ...
Cached Biology Technology:Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting 2Karyopharm Therapeutics Announces Multiple Presentations on Selective Inhibitors of Nuclear Export (SINE) in Solid and Hematologic Malignancy Models and Spontaneous Canine Cancers at the American Association of Cancer Research (AACR) Meeting 3Proteonomix Announces a Private Placement of $3.8 Million 2Proteonomix Announces a Private Placement of $3.8 Million 3Proteonomix Announces a Private Placement of $3.8 Million 4Organovo, Inc. Investor Presentation Now Available for On-Demand Viewing at RetailInvestorConferences.com 2
... Molecular Probes EnzChek Pyrophosphate Detection Kit,provides ... for measuring the inorganic pyrophosphate (PPi ... reactions, such as DNA and,RNA polymerizations, ... cyclase and the enzymatic activation of ...
... high PCR specificity *High PCR specificity ... enzyme with unique QIAGEN PCR Buffer ... provided by the stringent built-in hot ... Master Mix and simple reaction setup ...
Request Info...
... Thermo's Wellwash AC is the ... available, and is provided with liquid ... rinse bottles. The integrated orbital shaker ... guarantee excellent washing performance. The big ...
Biology Products: