Navigation Links
New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids

The immune system is a complex and powerful weapon that provides protection against bacteria and viruses that, if left unchecked, would wreak havoc throughout the human body. The ability of the immune system to recognize the body's own tissues is essential, but sometimes the immune system loses the ability to distinguish "self" from potentially harmful invaders. This can lead to autoimmune disease characterized by destruction of healthy tissues. Although it is not clear exactly what causes the immune system to go awry, there is increasing evidence that in some cases infections with viruses or bacteria may play a role. Now, a new study published in the June issue of Immunity provides evidence that bacterial infections induce a kind of self-recognition that may contribute to some autoimmune diseases such as multiple sclerosis (MS) and Guillain-Barre syndrome (GBS).

There is evidence that the development of certain autoimmune diseases may be associated with a bacterial or viral infection that stimulates production of antibodies and immune cells called T cells, which are targeted against bacterial proteins that closely resemble "self" proteins, leading to crossreactivity with healthy tissues. Dr. Gennaro De Libero from University Hospital in Basel, Switzerland, and colleagues identified a different mechanism where bacterial infections promote activation of T cells that recognize molecules called glycosphingolipids (GSL) that are present in bacteria and humans. The researchers show that infection with some bacteria or even just exposure to pieces of the outer wall of the bacteria results in an increase in "self" GSL synthesis by cells that promote the immune response and subsequent stimulation of autoreactive GSL-specific T cells.

"Collectively, these findings suggest that recognition of self by infection is an important mechanism leading to autoreactive T cell activation and, possibly, participates in the pathogenesis of some autoimmune diseases, such as
'"/>

Source:Cell Press


Page: 1 2

Related biology news :

1. New insight into people who see colors in letters and numbers
2. Alaskan puzzles, monitoring provide insight about North Pacific salmon runs
3. New insight into regulation of blood stem cells
4. New insights into how Huntingtons disease attacks the brain
5. Gambling monkeys give insight into neural machinery of risk
6. Structures of marine toxins provide insight into their effectiveness as cancer drugs
7. Flies on speed offer insight into the roles of dopamine in sleep and arousal
8. Grasshopper love songs give insight into sensory tuning
9. Studies on human genome variation provide insight into disease
10. Study provides insight into cellular defenses against genetic mutation
11. New insights into the software of life
Post Your Comments:
(Date:5/20/2015)... DUBLIN , May 20, 2015 ... Markets ( http://www.researchandmarkets.com/research/h8t4x6/5year ) has announced the ... of the Global Iris Recognition Market" ... http://photos.prnewswire.com/prnh/20130307/600769) , ,This research service analyses ... across the government and commercial sectors, ...
(Date:5/18/2015)... , May 18, 2015 Fingerprint ... sensors FPC1020, FPC1025, FPC1145, FPC1155 and FPC1035 from one if ... June until and including Q3 2015 and the sensors will ... . Communicated order values for 2015 hereby amount to 740 ... Q1 2015 of 140 MSEK and a number of smaller ...
(Date:5/11/2015)... 11, 2015 Curemark LLC, a privately held ... a new Phase III double blind, randomized, placebo-controlled clinical ... CM-AT, on all children ages 3-8 with Autism. Previously, ... III double blinded clinical trial for CM-AT in children ... the digestive enzyme chymotrypsin. This new trial will help ...
Breaking Biology News(10 mins):Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 230 Million and Raises Revenue Guidance for 2015 2Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2
... Genetic disease risk differences between one individual and another are ... the genes themselves, or else differences at the heart of ... By gene regulation we mean the decision that the cell ... activate or suppress the expression of a gene. In theory, ...
... those with HIV have recognized a relationship between how faithfully ... virus is to develop drug resistance. More recently, research has ... and resistance is different for each of the drugs that ... New research conducted by Harvard scientists could help explain ...
... ARBOR, Mich. Scientists have restored the sense of smell ... a hopeful sign for people who can,t smell anything from ... in curing congenital anosmia -- the medical term for lifelong ... other conditions that also stem from problems with the cilia. ...
Cached Biology News:A new light shed on genetic regulation's role in the predisposition to common diseases 2Design help for drug cocktails 2Design help for drug cocktails 3Can't smell anything? This discovery may give you hope 2Can't smell anything? This discovery may give you hope 3
(Date:6/1/2015)... June 1, 2015  Turing Pharmaceuticals AG announced that ... Salinas , MD, MSc,  has joined the company ... Dr. Salinas, who holds a medical degree as ... record of significant accomplishments in the pharmaceutical industry, ... Dr. Salinas has played a leadership role in ...
(Date:6/1/2015)... and YONGIN, South Korea ... great pride that Green Cross Biotherapeutics Inc. (GCBT) kicked ... be located on the Montreal Technoparc,s Saint-Laurent Campus. The ... field investment projects in Canada ... of the first intravenous immunoglobulin (IVIG) and albumin manufacturing ...
(Date:6/1/2015)... , June 1, 2015 ... Decipher® genomic analysis platform, successfully classified various ... genomic expression of certain biomarkers, including one ... Importantly, this unique genomic signature has potential ... to neoadjuvant chemotherapy in patients with muscle-invasive ...
(Date:6/1/2015)... Inc. (TSX-V: BRM) ("Biorem" or "the Company") today announced results for ... first quarter financial statements and MD&A have been filed on SEDAR ... 31,(in CDN$,000 except per share data) , 2015 , ... profit , 1,531 , 329 Ebitda* , ... , (531) Basic earnings (loss) per share ...
Breaking Biology Technology:Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 2Turing Pharmaceuticals Names Eliseo Salinas, MD and MSc, President of Research and Development 3Green Cross Biotherapeutics Kicks Off Construction in Montreal 2Green Cross Biotherapeutics Kicks Off Construction in Montreal 3GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 2GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 3GenomeDx's Decipher Platform Validates Genomic Signature that may Predict Resistance to Chemotherapy in Bladder Cancer Patients in Study Presented at ASCO 2015 Annual Meeting 4Biorem Reports Increased Revenues and Earnings for First Quarter 2Biorem Reports Increased Revenues and Earnings for First Quarter 3
... in reconstructive and aesthetic plastic surgeryMEDFORD, Mass., ... growth-stage medical device company developing silk-based biomaterial ... has received 510(k) clearance from the U.S. ... SeriScaffold (TM) silk-based, long term bioresorbable ...
... /PRNewswire/ - ImmunoVaccine Technologies Inc. (IVT), a vaccine ... the National Institute of Allergy and Infectious Diseases ... in Maryland, USA. The research collaboration involves formulating ... and exploring potential vaccines for HIV and malaria. ...
... its financial results for the year ending 31,December 2008. , , ... process for intravenous iclaprim in US, - Restructuring ... "intravenous-to-oral" Phase II trial with oral, ... - Share placing, Cash and financial investments of CHF ...
Cached Biology Technology:Serica Technologies Receives FDA 510(k) Clearance for SeriScaffold(TM) Technology for Soft Tissue Repair 2Serica Technologies Receives FDA 510(k) Clearance for SeriScaffold(TM) Technology for Soft Tissue Repair 3Serica Technologies Receives FDA 510(k) Clearance for SeriScaffold(TM) Technology for Soft Tissue Repair 4ImmunoVaccine Technologies Signs Agreement with National Institutes of Health to Explore Vaccines for HIV and Malaria 2Arpida Announces Full Year 2008 Financial Results 2Arpida Announces Full Year 2008 Financial Results 3Arpida Announces Full Year 2008 Financial Results 4Arpida Announces Full Year 2008 Financial Results 5
... Radiolabeled Ligands\n\nReceptor-related research has long been enabled ... ligands selected to keep pace with new ... products and services for receptor research and ... If you do not find exactly what ...
... The ICS-1500 system provides excellent performance ... pumping, electrolytic suppression, and column heater ... offers outstanding sensitivity and stability. The ... baselines for trace-level work. Operate in ...
... chemical suppression and thermally stabilized digital conductivity ... of common anions and cations over broad ... equilibrate, and fully automated with Chromeleon® SE ... maximum sample throughput at minimum cost. ...
... UNIchip AV-400 contains 400 unique human ... glass slide. The proteins, all intracellular ... classification, are arrayed in quadruplicate for ... a specific chip layout guarantee high ...
Biology Products: