Navigation Links
New influenza vaccine takes weeks to mass produce

Using cell-based methods researchers have developed a commercially viable method for mass producing effective vaccines against potential pandemic influenza strains in weeks instead of the months required for traditional egg-based vaccines. They report their results today at the 2006 ASM Biodefense Research

The next flu pandemic could happen any time," says Keyang Wang, a scientist at Protein Sciences Corporation (PSC) and a researcher on the study. "The most effective method to control such an outbreak is the widespread use of a vaccine, preferably in a pro-active manner, so that the immune system is primed prior to actual virus exposure. The traditional egg-based method requires 3 to 6 months to develop the vaccine. With our cell-based method, as soon as the pandemic strain is identified, a matched vaccine can be massively produced within 4 weeks."

The vaccine strategy pursued by Protein Sciences, known commercially as FluBlok, uses a purified protein from the surface of the virus called hemagglutinin (the H part of a virus' designation, like H5N1 for the current avian influenza) to elicit an immune response to a specific strain of influenza. The protein is produced by first extracting the genes responsible for the production of hemagglutinin from the influenza virus and inserting them into a baculovirus. Specific host cells are then infected with the baculovirus and produce recombinant hemagglutinin (rHA). Phase II clinical trials show that rHA-based vaccines produced using this system are safe, elicit immunity equal to or greater than egg-based vaccines, and are 100% effective in the prevention of cell culture confirmed influenza.

Wang and his colleagues report the successful production of rHA from 4 strains of influenza that scientists believe to be likely the cause of the next pandemic (H5, H7, H9, and H2) at a level where manufacturing costs are expected to be equal to or less than that of traditional egg-based vaccines.

"It has been suggested that the next pandemic strain may be derived from H5, H7, H9 or H2 influenza viruses. The preparation of the recombinant baculoviruses for the production of these antigens and the successful purifications gives us a great advantage in fighting against a potential influenza pandemic, if it derived from any of these strains," says Wang. "Starting from a stocked recombinant baculovirus bank, a closely matched vaccine can be massively produced within 2 weeks."

PSC has recently signed a Letter of Intent which will support commercial scale manufacturing with the capacity to produce 6 Million doses of monovalent pandemic vaccine per week.


'"/>

Source:American Society for Microbiology


Related biology news :

1. Computers to be used to find blueprint for new influenza drug
2. Less virulent strains of avian influenza can infect humans
3. Drug resistant avian influenza viruses more common in Southeast Asia than North America
4. New vaccine platform may fight infections with causes from influenza to bioterrorism
5. First big influenza genome study reveals flu evolution
6. Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs
7. Study outlines genetic differences between potential pandemic influenza strains
8. Avian influenza virus in mammals spreads beyond the site of infection to other organ systems
9. How can we protect patients with weakened immune systems from influenza?
10. Mouse study reveals new clues about virulence of 1918 influenza virus
11. Molecular anatomy of influenza virus detailed
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/16/2017)...   Bridge Patient Portal , an enterprise ... EMR Systems , an electronic medical record solutions ... established a partnership to build an interface between ... Centricityâ„¢ products, including Centricity Practice Solution (CPS), Centricity ... new integrations will allow healthcare delivery networks using ...
(Date:4/17/2017)... April 17, 2017 NXT-ID, Inc. (NASDAQ: ... the filing of its 2016 Annual Report on Form 10-K on ... ... is available in the Investor Relations section of the Company,s website ... SEC,s website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/11/2017)... N.Y. , April 11, 2017 ... fingerprints, but researchers at the New York University ... College of Engineering have found that partial similarities ... security systems used in mobile phones and other ... thought. The vulnerability lies in the ...
Breaking Biology News(10 mins):
(Date:9/25/2017)... and Portland, OR (PRWEB) , ... ... ... CallTower , an industry-leading Unified Communications (UC) and Collaboration company, and Bigleaf ... real-time, announced today a strategic alliance to extend CallTower’s Unified Communication applications ...
(Date:9/25/2017)... ... September 25, 2017 , ... Having met specific ... Design has been found to provide product development services that consistently ... our clients have a lot at stake when they invest in ...
(Date:9/25/2017)... ... September 25, 2017 , ... ... presenting multiple case studies, presentations and demonstrations at SCDM 2017, held September ... managers, medical review teams and CRO partners for more automated capabilities across ...
(Date:9/22/2017)... ... September 22, 2017 , ... ... raised nearly $200,000 via Kickstarter. The proceeds will be used to fund production ... B2v2, exceeding the original Kickstarter goal by nearly 1,000%. , The B2v2 is ...
Breaking Biology Technology: