Navigation Links
New imaging technique tracks traffic patterns of white blood cells

Researchers at Mount Sinai School of Medicine have just developed an advanced imaging technique to capture the movement of the microdomains of leukocytes or white blood cells. Microdomains are restricted areas on the surface of the cells in which receptors and signaling molecules accumulate during cell activation. Using digital multi-channel videomicroscopy, researchers were able to view white blood cell subsets and their forming microdomains in the vascular system in real time. In the upcoming March issue of Nature Methods, the new research displays the migration and inner workings of white blood cells in the small veins and bone marrow of mice.

"Intravital micropscopy (IVM) has contributed enormously to the recent mechanistic advances in leukocyte trafficking," wrote Mount Sinai School of Medicine researchers lead author Elaine Y. Chiang, Andres Hidalgo, Jungshan Chang and Paul S. Frenette of the Department of Medicine’s Immunobiology Center and Black Family Stem Cell Institute in New York. "Multichannel digital fluorescence videomicropscopy vastly improves on prior intravital observations of leukocyte behavior in vivo by allowing the near-simultaneous observation of cell surface markers and microdomains."

Researchers explored various mouse models including that of Sickle Cell disease which is a common inherited blood disorder in the United States, affecting 72,000 Americans according to the National Institutes of Health (NIH). Sickle Cell disease is a blood disorder that affects hemoglobin, a protein inside red blood cells that help carry oxygen throughout the body. Abnormal hemoglobin polymerizes, and red blood cells become sickle-shaped. Sickle-shaped red blood cells then clog blood vessels by sticking to white blood cells and depriving the body of needed oxygen.

Using this new imaging method, red blood cells in a mouse model of Sickle Cell disease were shown to interact specifically with neutrophils, a subset of inflammatory white
'"/>

Source:The Mount Sinai Hospital / Mount Sinai School of Medicine


Page: 1 2

Related biology news :

1. New imaging method gives early indication if brain cancer therapy is effective, U-M study shows
2. Duke engineers develop new 3-D cardiac imaging probe
3. Confocal imaging promises early detection of skin cancer
4. Newer imaging techniques may lead to over-treatment
5. Researchers use 3-D imaging system to unveil swimming behavior of microscopic plankton
6. Microscopic brain imaging in the palm of your hand
7. New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
8. Purdues gold nanorods brighten future for medical imaging
9. PET imaging reveals the immune system at work
10. New technique puts brain-imaging research on its head
11. T-rays: New imaging technology spotlighted by American Chemical Society
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New imaging technique tracks traffic patterns white blood cells

(Date:12/15/2014)... , Dec. 12, 2014 Research and Markets ... "Global Facial Recognition Market 2015-2019" report to ... Facial recognition is a technology used for ... overall facial feature of a person such as nose, ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays a role ... Hypertension – the medical term for high blood pressure – ... and the inflatable cuff that,s used in measuring blood pressure ... there,s nothing new about hypertension, its triggers and its effects. ...
(Date:12/10/2014)... a leader in performance biometric data sensor technology, today ... licensees for highly accurate, clinically validated biometric technology. This ... fitness and health sectors, but first responders/military and gaming ... as useful as the biometric data it delivers. As ...
Breaking Biology News(10 mins):Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4Wearable Technology Products Demand Highly Accurate Biometric Technology 2
... promising new vaccine against a pre-cancerous cervical virus shows ... cancer, according to a study presented today during the ... Cancer Prevention Research meeting in Baltimore. , ... in early October, confirmed the vaccine's efficacy from available ...
... Grand Challenges in Global health initiative to genetically engineer ... aid in testing the safety and effectiveness of potential ... Foundation, the Yale project will be headed by Richard ... at Yale University School of Medicine, and Howard Hughes ...
... gene enabling an insect virus to enter new cells was ... virus's use, researchers at Boyce Thompson Institute (BTI) at Cornell ... group of viruses that can liquefy their insect hosts in ... a sneeze in mammals, as potential pesticides. But the viruses ...
Cached Biology News:Updated data on novel HPV vaccine confirms efficacy in large population 2Grand Challenges in Global Health initiative funds Yale project 2Stolen gene allows insect virus to enter cells 2Stolen gene allows insect virus to enter cells 3
(Date:1/22/2015)... Dr. Greg Leyer of UAS Labs recently ... Supplements Pre-Conference seminar on probiotics in San Diego, CA. ... education conference for health care professionals. This year’s pre-conference seminar ... probiotics in health. Dr. Leyer spoke about the emerging topics ...
(Date:1/22/2015)... BRUNSWICK , Nueva Jersey , 22 de ... Award for Biomedical Research abre hoy su llamada a ... personas cuya investigación científica ha hecho, o tiene el ... la salud humana. Las nominaciones se aceptarán hasta el ...
(Date:1/22/2015)...  Derma Sciences, Inc. (Nasdaq: DSCI ), ... care, announces that AMNIOEXCEL® and AMNIOMATRIX®, amniotic allografts ... the Premier, Inc. Regenerative Skin Grafting contract portfolio. ... and AMNIOMATRIX® product lines, which continue to be ...
(Date:12/24/2014)... AUSTIN, Texas , Dec. 24, 2014  Vermillion, ... focused on gynecologic disease, announced today that the ... investors including Oracle Investment Management, Jack W. ... directors. Total proceeds were $10.5 million, before offering ...
Breaking Biology Technology:El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 2El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 3El Dr. Paul Janssen Award for Biomedical Research emite su llamada a los nominados para 2015 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 2Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 3Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 4Derma Sciences Expands Access of its AMNIOTIC TISSUE Product Line with New Premier, Inc. Agreement 5Vermillion Announces Closing of Equity Financing 2Vermillion Announces Closing of Equity Financing 3
... , ... announced that its Oragene®•DNA product has been selected by Prometheus as the sample collection ... for this type of genetic testing service as it solves sample collection challenges inherent ... ...
... SUNRISE, Fla., Aug. 18 Bioheart, Inc., (OTC ... and biologics that help monitor, diagnose and treat heart failure ... Directors have joined the Company,s executive management team. In addition ... of Directors, Karl E. Groth, Ph.D., became the Chief Executive ...
... , , BOSTON, Aug. 18 ... is pleased to host their September Congress taking place at the ... economic climate, with heightened M & A activity in the pharma ... governance has become more critical," says Sharon Langan, Senior Program Manager, ...
Cached Biology Technology:DNA Genotek Sample Collection Kit Selected by Prometheus for MyCeliacID™ Genetic Test 2DNA Genotek Sample Collection Kit Selected by Prometheus for MyCeliacID™ Genetic Test 3Bioheart Strengthens Executive Team in Order to Accelerate Business Plan and Enhance Its Position in the Cardiovascular Stem Cell Therapy Industry 2Bioheart Strengthens Executive Team in Order to Accelerate Business Plan and Enhance Its Position in the Cardiovascular Stem Cell Therapy Industry 3Bioheart Strengthens Executive Team in Order to Accelerate Business Plan and Enhance Its Position in the Cardiovascular Stem Cell Therapy Industry 4Bioheart Strengthens Executive Team in Order to Accelerate Business Plan and Enhance Its Position in the Cardiovascular Stem Cell Therapy Industry 5Bioheart Strengthens Executive Team in Order to Accelerate Business Plan and Enhance Its Position in the Cardiovascular Stem Cell Therapy Industry 6Bioheart Strengthens Executive Team in Order to Accelerate Business Plan and Enhance Its Position in the Cardiovascular Stem Cell Therapy Industry 7CBI Hosts 5th Annual Pharma/Biotech Enterprise Governance, Risk and Controls Congress 2
... Monoclonal Mouse Antibody to Cytokeratin 5 ... is a high molecular weight, basic type ... and the superficial cell layers of stratified ... epithelia and in mesothelial cells and mesothelioma. ...
...
Aldolase A (N-15)...
Bovine Renal Artery Endothelial Cells (BRAEC) (>500,000 cells)...
Biology Products: