Navigation Links
New imaging method gives early indication if brain cancer therapy is effective, U-M study shows

later that it had no effect? Using MRI tumor diffusion values to accurately predict the treatment response early on could allow some patients to switch to a more beneficial therapy and avoid the side effects of a prolonged and ineffective treatment," said Brian Ross, Ph.D., professor of radiology and biological chemistry at the U-M Medical School and a member of the U-M Comprehensive Cancer Center.

In the study, 20 participants with brain tumors underwent diffusion MRI before beginning a new treatment involving chemotherapy, radiation therapy or a combination. Three weeks later, they had another diffusion MRI. After finishing their treatment, the participants underwent standard MRI to determine whether their tumor responded to the therapy.

After three weeks ?more than two months before the final MRI scan ?researchers found significant differences between the patients' scans. Some areas reflected an increase in water diffusion, suggesting tumor cell death; other areas saw a decrease in diffusion, which Ross said could be accounted for by the swelling some cells undergo before dying; and in some participants, researchers saw no change in diffusion.

"In the end, we found if the diffusion changes in any way, up or down, it correlates to a positive outcome. The magnitude or amount of change relates to the effectiveness of treatment. This indicates a different mixture of cell death pathways within the tumors. In the end, any change is good. When you think about it, if the treatment is not having an effect, the tumor will continue to grow without any change to water diffusion," Ross said.

The researchers found that for each of the 20 patients, a change in the diffusion MRI accurately predicted the tumor's response. Researchers plan to test the technique with breast cancer and head and neck cancer.

In addition to Ross, U-M study authors are Bradford Moffat, Ph.D., assistant professor of radiology; Thomas Chenevert, Ph.D., professor of
'"/>

Source:University of Michigan Health System


Page: 1 2 3

Related biology news :

1. Duke engineers develop new 3-D cardiac imaging probe
2. Confocal imaging promises early detection of skin cancer
3. Newer imaging techniques may lead to over-treatment
4. Researchers use 3-D imaging system to unveil swimming behavior of microscopic plankton
5. Microscopic brain imaging in the palm of your hand
6. New imaging technology shown to detect pancreatic inflammation in type 1 diabetes
7. Purdues gold nanorods brighten future for medical imaging
8. PET imaging reveals the immune system at work
9. New technique puts brain-imaging research on its head
10. T-rays: New imaging technology spotlighted by American Chemical Society
11. UCLA imaging study of children with autism finds broken mirror neuron system
Post Your Comments:
(Date:7/11/2014)... Researchers from Salk Institute for Biological Studies, BGI, ... the safety and reliability of the existing targeted ... method, TALEN-HDAdV, which could significantly increased gene-correction efficiency ... study published online in Cell Stell Cell ... cell-based gene therapy. , The combination of stem ...
(Date:7/11/2014)... Ume University, Sweden, have explored two different ways ... sequence leading to the formation of oxygen molecules ... in the scientific journal Nature Communications . ... day synthetic catalysts for water oxidation, which are ... the direct storage of solar energy in fuels ...
(Date:7/11/2014)... of mesenchymal stem cells can stimulate neurogenesis in the ... disease (AD) and improve tissue and function injury under ... on the therapeutic effect of adipose-derived stem cells (ADSCs) ... on oxidative injury and neurogenesis in the brain of ... of Life Sciences, Tsinghua University, China transplanted ADSCs into ...
Breaking Biology News(10 mins):A new genome editing method brings the possibility of gene therapies closer to reality 2Molecular snapshots of oxygen formation in photosynthesis 2
... snakes, tumour cells shed their skin. Cancer is not ... accumulates changes to evade natural defences adapting to new ... neighbouring organs, eventually causing metastasis. Until now little ... processes in a tumour. There is a particularly intriguing ...
... Yale University researchers have identified a key genetic gear ... that could have broad implications for global agriculture. The ... Molecular Cell. "Farmers are limited by the ... controls basic functions such as photosynthesis and flowering, we might ...
... detective work by an international group of researchers may have ... tree-killing fungus that has hit six of the world,s seven ... 1) in the peer-reviewed journal Phytopathology , California emerged ... is the cause of cypress canker disease. It was ...
Cached Biology News:Why cancer cells change their appearance? 2Tree-killing pathogen traced back to California 2Tree-killing pathogen traced back to California 3Tree-killing pathogen traced back to California 4Tree-killing pathogen traced back to California 5
(Date:7/10/2014)... DUBLIN , July 10, 2014 ... the addition of the "International Photonic Integrated ... - Forecasts to 2019" report to their ... The concept of photonic integration traces ... twentieth century. The promise of photonic integration went ...
(Date:7/10/2014)... University of Adelaide research may help in the fight ... can detect tiny quantities of explosives with the use ... the journal Sensors and Actuators B: Chemical , ... can detect explosives in concentrations as low as 6.3 ... of only a few minutes. , "Traditionally explosives detection ...
(Date:7/10/2014)... has been extremely challenging because there are many genetic ... cause disease. Now investigators reporting in the July 3rd ... Cell describe a strategy that may help reveal ... factors or environmental exposures to affect the development of ... that may predispose individuals to schizophrenia. , The ...
(Date:7/10/2014)... forever. Nanophysics makes sure of that. Mechanics researchers at Linkping ... Physical Review E . Knowledge that can be of ... be able to sit still forever, and walk around upside ... soon be able to buy smart new fasteners that hold ... is, sooner or later the grip is lost, no matter ...
Breaking Biology Technology:International Photonic Integrated Circuit (Monolithic Integration, Hybrid Integration, Module Integration) Market - Forecasts to 2019 2Detecting trace amounts of explosives with light 2New strategy could uncover genes at the root of psychiatric illnesses 2Even geckos can lose their grip 2
... , , BOTHELL, ... BLFS), a leading developer, manufacturer, and marketer of biopreservation tools ... its BloodStor biopreservation media product platform. The product family ... cells, as well as other variants for peripheral blood derived ...
... FREDERICK, Md., Aug. 28 SABiosciences announces its inclusion ... 30 Best Places to Work Industry Survey. Best Places to Work ... environment, dedicated management, and innovative ways to motivate their workforce. SABiosciences ... and pharmaceutical companies. , , "We ...
... , , , ... TUSTIN, Calif., Aug. 28 Avid Bioservices, Inc., a leading provider of ... it has further strengthened its executive team with the appointments of Truc ... business operations. These additions reflect Avid,s recent successes in expanding its ...
Cached Biology Technology:BloodStor(TM) Stem Cell Biopreservation Media Platform Launched by BioLife Solutions 2BloodStor(TM) Stem Cell Biopreservation Media Platform Launched by BioLife Solutions 3SABiosciences Ranked 17th on the Best Places to Work Industry Award for Biotech and Pharmaceutical Companies 2Avid Bioservices Expands Executive Team as it Prepares for Continued Growth 2Avid Bioservices Expands Executive Team as it Prepares for Continued Growth 3Avid Bioservices Expands Executive Team as it Prepares for Continued Growth 4Avid Bioservices Expands Executive Team as it Prepares for Continued Growth 5
Anti-gamma Glutamyl Transferase (gammaGT) Host: mouse monoclonal Species Reactivity: human Applications: WB, IP, FC Storage: 4C...
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... Product Goat polyclonal to ... (Microorganism). Reactivity / Specificity Cross-reacts ... species. Background Information Cholesterol oxidases ... II oxidases and are implicated in bacterial ...
Anti-ACTH Immunogen: Porcine ACTH conjugated to BSA. Available Date: 38566...
Biology Products: