Navigation Links
New hereditary breast cancer gene discovered

A new hereditary breast cancer gene has been discovered by scientists at the Lundberg Laboratory for Cancer Research and the Plastic Surgery Clinic at the Sahlgrenska Academy in Sweden. The researchers found that women with a certain hereditary deformity syndrome run a nearly twenty times higher risk of contracting breast cancer than expected.

Several research teams around the world have long been searching for new hereditary breast cancer genes, but thus far few have been found.

"Our findings are extremely important, providing new knowledge of hereditary cancer genes and how they can cause breast cancer. The discovery also makes it possible to uncover breast cancer in women who have a predisposition for Saethre-Chotzen malformation syndrome," says Göran Stenman.

By detailed mapping of families with Saethre-Chotzen syndrome, the Göteborg scientists have now found that women with this syndrome have an elevated risk of contracting breast cancer. Saethre-Chotzen is a syndrome that primarily involves malformations of the skull, face, hands, and feet. The syndrome is caused by mutations in a gene called TWIST1.

"Our findings show that women with this syndrome run a nearly twenty times greater risk of contracting breast cancer than expected. Moreover, many of the women were young when they were affected by breast cancer," says Göran Stenman.

The findings of the study show that women with this syndrome should be receive early mammograms in order to discover breast cancer at an early stage.

"We have already started to use this new knowledge in our work with patients and now recommend regular mammograms for young women with this syndrome. Several early cases of breast cancer have already been uncovered with mammography," says Pelle Sahlin, chief physician at the Plastic Surgery Clinic.

The scientists are now going to perform various experiments to chart the mechanism of how TWIST1 increases the risk of breast cancer. Studies are also under way to find out what proportion of cases of hereditary breast cancer are caused by mutations in the TWIST1 gene.
'"/>

Source:Swedish Research Council


Related biology news :

1. UF scientists test improved gene therapy method for hereditary heart conditions
2. Gene therapy for hereditary lung disease advances
3. Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors
4. Viral DNA sequence a possible trigger for breast cancer
5. Used in a new way, RNA interference permanently silences key breast cancer gene
6. Biomarkers isolated from saliva successfully predict oral and breast cancer
7. Study reveals dramatic difference between breast cancers in US and Africa
8. Compounds in plastic packaging act as environmental estrogens altering breast genes
9. Alcohol consumption disrupts breastfeeding hormones
10. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
11. Scientists discover genetic pathway responsible for breast cancer cell growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/16/2018)... ... October 15, 2018 , ... ... solutions for highly regulated industries, is a silver sponsor and exhibitor at the ... , The Biomanufacturing World Summit brings together the “who’s who” of ...
(Date:10/16/2018)... ... October 16, 2018 , ... ... development, announces a new publication titled, “ Graphene-based Biosensor for On-Chip Detection of ... describes Agile R100 as a “new portable digital device for biosensing… that can ...
(Date:10/16/2018)... and BOSTON (PRWEB) , ... ... ... , a global leader in delivering cloud-based enterprise-class unified communications and collaboration ... delivers enhanced network stability by directly connecting CallTower data centers to a ...
Breaking Biology News(10 mins):
(Date:10/16/2018)... ... October 15, 2018 , ... Since the inception of the ... by eye wherein key features are used for classification. While this type of ... highly limited in that it is a qualitative and low-throughput approach where only ...
(Date:10/16/2018)... ... October 15, 2018 , ... The American Medical Informatics Association (AMIA) is ... receive their awards at the AMIA 2018 Annual Symposium , taking place Nov. ... attendees. This year garnered more than 700 submissions. The AMIA Signature Awards program provides ...
(Date:10/13/2018)... , ... October 12, 2018 , ... ... society for laser education, innovation and commercialization, celebrates its 50th birthday in New ... Applications of Lasers and Electro-Optics (ICALEO) conference. , In celebration of its ...
(Date:10/11/2018)... ... October 10, 2018 , ... ... announces the appointment of Wendy Nelson, PhD, as its new CEO. , Dr. ... experience in the biotech industry. Most recently, Dr. Nelson was VP of ...
Breaking Biology Technology: