Navigation Links
New hereditary breast cancer gene discovered

A new hereditary breast cancer gene has been discovered by scientists at the Lundberg Laboratory for Cancer Research and the Plastic Surgery Clinic at the Sahlgrenska Academy in Sweden. The researchers found that women with a certain hereditary deformity syndrome run a nearly twenty times higher risk of contracting breast cancer than expected.

Several research teams around the world have long been searching for new hereditary breast cancer genes, but thus far few have been found.

"Our findings are extremely important, providing new knowledge of hereditary cancer genes and how they can cause breast cancer. The discovery also makes it possible to uncover breast cancer in women who have a predisposition for Saethre-Chotzen malformation syndrome," says Göran Stenman.

By detailed mapping of families with Saethre-Chotzen syndrome, the Göteborg scientists have now found that women with this syndrome have an elevated risk of contracting breast cancer. Saethre-Chotzen is a syndrome that primarily involves malformations of the skull, face, hands, and feet. The syndrome is caused by mutations in a gene called TWIST1.

"Our findings show that women with this syndrome run a nearly twenty times greater risk of contracting breast cancer than expected. Moreover, many of the women were young when they were affected by breast cancer," says Göran Stenman.

The findings of the study show that women with this syndrome should be receive early mammograms in order to discover breast cancer at an early stage.

"We have already started to use this new knowledge in our work with patients and now recommend regular mammograms for young women with this syndrome. Several early cases of breast cancer have already been uncovered with mammography," says Pelle Sahlin, chief physician at the Plastic Surgery Clinic.

The scientists are now going to perform various experiments to chart the mechanism of how TWIST1 increases the risk of breast cancer. Studies are also under way to find out what proportion of cases of hereditary breast cancer are caused by mutations in the TWIST1 gene.
'"/>

Source:Swedish Research Council


Related biology news :

1. UF scientists test improved gene therapy method for hereditary heart conditions
2. Gene therapy for hereditary lung disease advances
3. Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors
4. Viral DNA sequence a possible trigger for breast cancer
5. Used in a new way, RNA interference permanently silences key breast cancer gene
6. Biomarkers isolated from saliva successfully predict oral and breast cancer
7. Study reveals dramatic difference between breast cancers in US and Africa
8. Compounds in plastic packaging act as environmental estrogens altering breast genes
9. Alcohol consumption disrupts breastfeeding hormones
10. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
11. Scientists discover genetic pathway responsible for breast cancer cell growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/26/2017)...  Securus Technologies, a leading provider of civil ... investigation, corrections and monitoring, announces the appointment of ... "Too often, too many offenders return to jail ... trying to tackle this ongoing problem and improve ... members. While significant steps are underway, Securus continues to ...
(Date:2/21/2017)... February 21, 2017 Der weltweite ... wachsen. Nach einem Gespräch mit mehr als 50 Vertretern aus ... zu überwinden gilt, um diese Prognose zu realisieren. ... ... Mobilisierung der finanziellen Mittel für die Biobank, die Implementierung ...
(Date:2/13/2017)... WASHINGTON , Feb. 13, 2017 Former ... U.S. Senate Judiciary Committee, Janice Kephart of ... regarding President Donald Trump,s "Executive Order: Protecting ... States" (Jan. 27, 2017):  "As President Trump,s ... 9th Circuit has now essentially banned the travel ban, ...
Breaking Biology News(10 mins):
(Date:3/29/2017)... March 29, 2017 /PRNewswire/ - The University of Missouri ... a business of Sterigenics International, and General Atomics (GA), ... submitted to the U.S. Nuclear Regulatory Commission (NRC). This ... of molybdenum-99 (Mo-99). Once operational, production from this facility ... demand for Mo-99, which currently must be imported from ...
(Date:3/29/2017)... The Global Microfluidic Chips Market by Manufacturers, ... and comprehensive study on the existing state of the global Microfluidic ... Europe and Asia-Pacific , ... and Africa . ... Browse 172 Tables and Figures, 13 Major Company ...
(Date:3/28/2017)... ... , ... Mass spectrometry is becoming more widely for clinical testing and evaluation ... potential to perform challenging analyses in complex matrices and sample types. While mass spectrometry ... it to be routinely used for medical testing. , In this webinar, ...
(Date:3/28/2017)... Ann Arbor, Michigan (PRWEB) , ... March 28, ... ... company was awarded a Phase II Small Business Innovation Research (SBIR) grant from ... will receive approximately $750,000 over two years to develop a suite of BioGel™ ...
Breaking Biology Technology: