Navigation Links
New hereditary breast cancer gene discovered

A new hereditary breast cancer gene has been discovered by scientists at the Lundberg Laboratory for Cancer Research and the Plastic Surgery Clinic at the Sahlgrenska Academy in Sweden. The researchers found that women with a certain hereditary deformity syndrome run a nearly twenty times higher risk of contracting breast cancer than expected.

Several research teams around the world have long been searching for new hereditary breast cancer genes, but thus far few have been found.

"Our findings are extremely important, providing new knowledge of hereditary cancer genes and how they can cause breast cancer. The discovery also makes it possible to uncover breast cancer in women who have a predisposition for Saethre-Chotzen malformation syndrome," says Göran Stenman.

By detailed mapping of families with Saethre-Chotzen syndrome, the Göteborg scientists have now found that women with this syndrome have an elevated risk of contracting breast cancer. Saethre-Chotzen is a syndrome that primarily involves malformations of the skull, face, hands, and feet. The syndrome is caused by mutations in a gene called TWIST1.

"Our findings show that women with this syndrome run a nearly twenty times greater risk of contracting breast cancer than expected. Moreover, many of the women were young when they were affected by breast cancer," says Göran Stenman.

The findings of the study show that women with this syndrome should be receive early mammograms in order to discover breast cancer at an early stage.

"We have already started to use this new knowledge in our work with patients and now recommend regular mammograms for young women with this syndrome. Several early cases of breast cancer have already been uncovered with mammography," says Pelle Sahlin, chief physician at the Plastic Surgery Clinic.

The scientists are now going to perform various experiments to chart the mechanism of how TWIST1 increases the risk of breast cancer. Studies are also under way to find out what proportion of cases of hereditary breast cancer are caused by mutations in the TWIST1 gene.
'"/>

Source:Swedish Research Council


Related biology news :

1. UF scientists test improved gene therapy method for hereditary heart conditions
2. Gene therapy for hereditary lung disease advances
3. Study examines risk of soft tissue sarcomas in hereditary retinoblastoma survivors
4. Viral DNA sequence a possible trigger for breast cancer
5. Used in a new way, RNA interference permanently silences key breast cancer gene
6. Biomarkers isolated from saliva successfully predict oral and breast cancer
7. Study reveals dramatic difference between breast cancers in US and Africa
8. Compounds in plastic packaging act as environmental estrogens altering breast genes
9. Alcohol consumption disrupts breastfeeding hormones
10. VCU Massey Cancer Center study shows enzyme linked to spread of breast cancer cells
11. Scientists discover genetic pathway responsible for breast cancer cell growth

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/8/2016)... Calif. , Dec. 8, 2016  Singulex, Inc., ... Molecule Counting technology, entered into a license and supply ... serving science. The agreement provides Singulex access to Thermo ... Europe is used to diagnose systemic ... United States to aid in assessing the ...
(Date:12/7/2016)... , December 7, 2016 BioCatch , ... expansion of its patent portfolio, which grew to over 40 granted and ... , , ... recently filed patent entitled " System, Device, and Method Estimating ... that enables device makers to forego costly hardware components needed to estimate ...
(Date:12/7/2016)... 7, 2016   Veridium , a leader ... of new CEO James Stickland . Stickland, ... of experience, has served in senior executive roles ... specialized in expanding a pipeline of venture capital ... most recently served as managing director of U.K.-based ...
Breaking Biology News(10 mins):
(Date:1/16/2017)... ... January 16, 2017 , ... Appellate Court of New Jersey ... appeal filed by India-based Dishman Pharmaceutical & Chemical Ltd. company (DPCL) for its ... of its Dishman Group’s 100% wholly owned New Jersey-based subsidiary Dishman USA located ...
(Date:1/14/2017)... 13, 2017  The Alliance for Safe Biologic Medicines ... FDA final guidance on biologic naming: ... in emphasizing the importance of distinct naming for all ... the benefits biosimilars will bring to patients, including new ... the portion of the Guidance dealing with suffix design ...
(Date:1/13/2017)... Island, NY (PRWEB) , ... January 13, 2017 ... ... teamed up with several companies to offer its customers three new solutions for ... probe would come in handy if a customer has an oddly-shaped sample that ...
(Date:1/12/2017)... ... January 12, 2017 , ... ... 26-year-old Lisa Rosendahl’s doctors gave her only a few months to live. Now ... combination that has stabilized Rosendahl’s disease and increased both the quantity and quality ...
Breaking Biology Technology: