Navigation Links
New gene scanning technology marks a major advance in disease research

Gene scanning techniques developed by Professor Ian Day and colleagues at the University of Southampton are set to have a major impact on healthcare in the future.

One of two gene mutation scanning techniques devised by Professor Day and his team in the Human Genetics Division of the University's School of Medicine has been successfully applied to search for rare genetic mutations in the population at large.

Their method, called meltMADGE, which combines thermal ramp electrophoresis with microplate array diagonal gel electrophoresis (MADGE), enables significantly higher levels of scanning at a fraction of the cost.

Using the Southampton technique a network of British medical researchers from the Universities of Southampton, Bristol and University College London, funded by the UK's Medical Research Council, British Heart Foundation and Department of Health, studied a gene which affects blood cholesterol levels. In analyses of nearly 10,000 middle-aged individuals, they found some rare mutations associated with very high cholesterol, some with moderately high cholesterol and some with no effect.

This is the first time that it has been possible to find out whether there may be unknown rare genetic variations in the population which may cause mild forms of a particular disease or feature in just one or two individuals, or may even protect them against disease.

Professor Day commented: 'This development enables us to look at the whole population and find rare and "special" individuals with gene changes which may have either mild, moderate, severe or protective disease effects, a bit like the medical equivalent of finding a needle in a haystack.

'While this approach is currently at the research level, in the future it could lead to a very personalised genetic profile of a whole range of genes relevant to lifestyle, health and drug prescribing, leading to more personalised medicine and screening.'

Professor Day's group
'"/>

Source:Cold Spring Harbor Laboratory


Page: 1 2

Related biology news :

1. Novel technology detects human DNA mutations
2. Novel antiviral technology inhibits RSV infection in mice
3. The BIOS Initiative - open source biotechnology is born
4. Revolutionary nanotechnology illuminates brain cells at work
5. Study: homemade gene expression technology unreliable
6. First technology to remove prions that cause vCJD from blood launched
7. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
10. First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
11. Vietnam war technology could aid elephant conservation
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New gene scanning technology marks major advance disease research

(Date:4/24/2014)... New Rochelle, NY, April 24, 2014D-ribose is a ... nutritional supplement, and as a starting compound for ... of Escherichia coli to increase the ... step toward achieving more efficient industrial-scale production of ... in Industrial Biotechnology , a peer-reviewed journal ...
(Date:4/24/2014)... simple and cheap way of making a high-powered lens ... microscope. , Costing less than a cent, the lenses ... countries and remote areas. , The lens fabrication technique ... National University (ANU) Research School of Engineering, who collaborated ... Medical Research to find ways to transform the lentil-sized ...
(Date:4/24/2014)... Initial treatment for a brain infection caused by fungus could ... due to study by University of Liverpool scientists. , ... often fatal but are relatively neglected in medical research. ... Africa, Australasia and South East Asia and mainly affect people ... people a year. , The University research team has tested ...
Breaking Biology News(10 mins):Droplet lens 2Treatment for deadly yeast disease reduced to 3 days 2
... Reportlinker.com announces that a new market research report is ... Forecast to 2012 - http://www.reportlinker.com/p096440/Global-Biometric-Forecast-to-2012.html ... the fastest emerging markets for the past few years ... and the advent of new technologies that offered numerous ...
... and "Invasive Alien Species in the Caribbean Basin of Concern ... will be presented at a joint meeting between the Southeastern ... Caribbean Division of the American Phytopathological Society (APS). The ... San Juan, March 19-22, 2011, as hundreds of entomologists and ...
... To the surprisingly inventive uses for banana peels ... of house plants scientists have added purification of ... which concludes that minced banana peel performs better than ... journal Industrial & Engineering Chemistry Research . ...
Cached Biology News:Reportlinker Adds Global Biometric Forecast to 2012 2CSI and alien invaders in Puerto Rico 2
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014 ... two institutes from the National Institutes of Health (NIH) ... safer, more effective treatments to patients on a faster ... Advancing Translational Sciences (NCATS) and the National Eye Institute ...
(Date:1/14/2014)... 14, 2014 In recent years, growing ... methods in product development and promotion has led to ... mistrust, fueled by concerns about the insidious impact of ... of spectacular fines to the world’s biggest pharmas for ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Global ... developing innovative information technology solutions for patients, physicians, ... care stakeholders, announced today the signing of a ... Food and Drug Administration (FDA). This initiative ...
(Date:1/14/2014)... UK (PRWEB) January 13, 2014 Bob ... with more than 20 years in the industry, has ... photonics . Hainsey will serve as the society’s Science ... Dr. Hainsey join SPIE as our Technology Strategist, further ...
Breaking Biology Technology:Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 2The Sunshine Act: Necessary Regulation or Unnecessary Dysregulation? New Life Science Webinar Hosted by Xtalks and IRB Services 3Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... With the first observation of thermoelectric effects at ... transistors have a nanoscale cooling effect that reduces their ... William King and electrical and computer engineering professor Eric ... April 3 advance online edition of the journal ...
... conventional optical instruments, light cannot be focused to spot ... effects. An important approach to beat this diffraction ... an allusion to their radiofrequency counterparts. They have the ... nanometer-scale dimensions, which are orders of magnitude smaller than ...
... Diego have produced the first high resolution structure of a ... was published in a paper in this week,s early online ... of Sciences by a team of chemists headed by ... UCSD. The scientists said the ability to carry structural ...
Cached Biology Technology:Self-cooling observed in graphene electronics 2Transmission lines for nanofocusing of infrared light 2Transmission lines for nanofocusing of infrared light 3
...
RABBIT ANTI PORCINE CARBOXYPEPTIDASE B...
LabFax: Immunochemistry...
... Maker, 1. Modular system for large ... up to six lab-cast or precast ... with 18- or 24-cm Immobiline DryStrip ... gel cassettes.Innovative design simplifies loading and ...
Biology Products: