Navigation Links
New gene scanning technology marks a major advance in disease research

Gene scanning techniques developed by Professor Ian Day and colleagues at the University of Southampton are set to have a major impact on healthcare in the future.

One of two gene mutation scanning techniques devised by Professor Day and his team in the Human Genetics Division of the University's School of Medicine has been successfully applied to search for rare genetic mutations in the population at large.

Their method, called meltMADGE, which combines thermal ramp electrophoresis with microplate array diagonal gel electrophoresis (MADGE), enables significantly higher levels of scanning at a fraction of the cost.

Using the Southampton technique a network of British medical researchers from the Universities of Southampton, Bristol and University College London, funded by the UK's Medical Research Council, British Heart Foundation and Department of Health, studied a gene which affects blood cholesterol levels. In analyses of nearly 10,000 middle-aged individuals, they found some rare mutations associated with very high cholesterol, some with moderately high cholesterol and some with no effect.

This is the first time that it has been possible to find out whether there may be unknown rare genetic variations in the population which may cause mild forms of a particular disease or feature in just one or two individuals, or may even protect them against disease.

Professor Day commented: 'This development enables us to look at the whole population and find rare and "special" individuals with gene changes which may have either mild, moderate, severe or protective disease effects, a bit like the medical equivalent of finding a needle in a haystack.

'While this approach is currently at the research level, in the future it could lead to a very personalised genetic profile of a whole range of genes relevant to lifestyle, health and drug prescribing, leading to more personalised medicine and screening.'

Professor Day's group is using combinations of meltMADGE and a second technology called endo VII MADGE to explore variations in the whole population of disease genes relevant to growth, obesity and cardiovascular disease.


'"/>

Source:Cold Spring Harbor Laboratory


Related biology news :

1. Novel technology detects human DNA mutations
2. Novel antiviral technology inhibits RSV infection in mice
3. The BIOS Initiative - open source biotechnology is born
4. Revolutionary nanotechnology illuminates brain cells at work
5. Study: homemade gene expression technology unreliable
6. First technology to remove prions that cause vCJD from blood launched
7. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
10. First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
11. Vietnam war technology could aid elephant conservation
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2018)... BOSTON (PRWEB) , ... August 01, 2018 , ... Dr. ... today announced the winning recipients of the 2018 IAC Awards at the 23rd World ... awards, the committee also named four faculty to receive the Distinguished Fellowship Awards. , ...
(Date:8/1/2018)... ... August 01, 2018 , ... ... RN’s, LPN’s, MA's and Administrative staff. , This full day course is an ... The course will expose your staff to regenerative medicine procedures and processing techniques, ...
(Date:7/31/2018)... CHICAGO, Ill and CARLSBAD, Calif. (PRWEB) , ... July 31, 2018 ... ... SnapGene software to connect seamlessly with LabArchives , the leading cloud-based ... of molecular biology procedures and LabArchives enables researchers to store all of their research ...
Breaking Biology News(10 mins):
(Date:8/1/2018)... ... August 01, 2018 , ... ... significant impact of a proprietary biofield energy treated supplement that potentially improves ... biomarkers for systemic and organ-specific inflammation, as well as, immune function response. ...
(Date:7/27/2018)... WASHINGTON (PRWEB) , ... July ... ... Biobased and Renewable Products Advocacy Group (BRAG®) and representatives of the Biotechnology ... discuss the two groups’ recently-issued white paper, “Proposal for a Toxic Substances ...
(Date:7/25/2018)... , ... July 25, 2018 , ... ... research utilizing its state-of-the-art Digital Vivarium™ and Vium Cloud approach to accelerate preclinical ... Chief Scientific Officer. Additionally, the company announced the appointment of Jeff Caron to ...
(Date:7/24/2018)... ... July 23, 2018 , ... Mark Stutheit, an evidence-based ... increase immunity and improve anti-inflammatory, and immune function responses. , Biomarkers for systemic ... research were significantly reduced. Results are as follows:, , ...
Breaking Biology Technology: