Navigation Links
New gene scanning technology marks a major advance in disease research

Gene scanning techniques developed by Professor Ian Day and colleagues at the University of Southampton are set to have a major impact on healthcare in the future.

One of two gene mutation scanning techniques devised by Professor Day and his team in the Human Genetics Division of the University's School of Medicine has been successfully applied to search for rare genetic mutations in the population at large.

Their method, called meltMADGE, which combines thermal ramp electrophoresis with microplate array diagonal gel electrophoresis (MADGE), enables significantly higher levels of scanning at a fraction of the cost.

Using the Southampton technique a network of British medical researchers from the Universities of Southampton, Bristol and University College London, funded by the UK's Medical Research Council, British Heart Foundation and Department of Health, studied a gene which affects blood cholesterol levels. In analyses of nearly 10,000 middle-aged individuals, they found some rare mutations associated with very high cholesterol, some with moderately high cholesterol and some with no effect.

This is the first time that it has been possible to find out whether there may be unknown rare genetic variations in the population which may cause mild forms of a particular disease or feature in just one or two individuals, or may even protect them against disease.

Professor Day commented: 'This development enables us to look at the whole population and find rare and "special" individuals with gene changes which may have either mild, moderate, severe or protective disease effects, a bit like the medical equivalent of finding a needle in a haystack.

'While this approach is currently at the research level, in the future it could lead to a very personalised genetic profile of a whole range of genes relevant to lifestyle, health and drug prescribing, leading to more personalised medicine and screening.'

Professor Day's group is using combinations of meltMADGE and a second technology called endo VII MADGE to explore variations in the whole population of disease genes relevant to growth, obesity and cardiovascular disease.


'"/>

Source:Cold Spring Harbor Laboratory


Related biology news :

1. Novel technology detects human DNA mutations
2. Novel antiviral technology inhibits RSV infection in mice
3. The BIOS Initiative - open source biotechnology is born
4. Revolutionary nanotechnology illuminates brain cells at work
5. Study: homemade gene expression technology unreliable
6. First technology to remove prions that cause vCJD from blood launched
7. Integration of Agilents MS technology, Proteome Systems software to help scientists in proteomics research
8. Agilent Technologies new genome analysis technology set to accelerate Australia fight against mesothelioma
9. Recombinant DNA technology may enable oral, rather than injectable, delivery of protein drugs
10. First production of human monoclonal antibodies in chicken eggs published in Nature Biotechnology
11. Vietnam war technology could aid elephant conservation
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/24/2016)... , May 24, 2016 Ampronix facilitates superior patient care by providing unparalleled ... medical LCD display is the latest premium product recently added to the range of ... ... ... Sony 3d Imaging- LCD Medical Display- Ampronix News ...
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC , ... announced the opening of an IoT Center of Excellence ... and expand the development of embedded iris biometric applications. ... level of convenience and security with unmatched biometric accuracy, ... identity aside from DNA. EyeLock,s platform uses video technology ...
(Date:5/9/2016)... May 9, 2016 Elevay is ... to expanding freedom for high net worth professionals seeking ... today,s globally connected world, there is still no substitute ... ever duplicate sealing your deal with a firm handshake. ... by taking advantage of citizenship via investment programs like ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... June 27, 2016 , ... Newly created ... services and solutions to the healthcare market. The company's primary focus is on ... sales and marketing strategies that are necessary to help companies efficiently bring their ...
(Date:6/24/2016)... 24, 2016 Epic Sciences unveiled a ... susceptible to PARP inhibitors by targeting homologous recombination ... The new test has already been incorporated into ... cancer types. Over 230 clinical trials ... pathways, including PARP, ATM, ATR, DNA-PK and WEE-1. ...
(Date:6/23/2016)... , June 23, 2016   Boston ... of novel compounds designed to target cancer stemness ... has been granted Orphan Drug Designation from the ... treatment of gastric cancer, including gastroesophageal junction (GEJ) ... inhibitor designed to inhibit cancer stemness pathways by ...
(Date:6/23/2016)... , June 23, 2016  The Prostate Cancer Foundation (PCF) is ... treatments and faster cures for prostate cancer. Members of the Class of 2016 ... countries. Read More About the Class of 2016 PCF ... ... ...
Breaking Biology Technology: