Navigation Links
New gene reduces retinal degeneration in fruit flies

Johns Hopkins researchers have discovered a gene in fruit flies that helps certain specialized neurons respond more quickly to bright light. The study, published in the April 4 issue of Current Biology, also has implications for understanding sensory perception in mammals.

In teasing apart the molecular interactions and physiology underlying light perception, the researchers studied a gene they dubbed "Lazaro" that is expressed 15 times higher in the fly eye than the rest of the fly head. They found that this gene is required for a second biochemical pathway that controls the activity of a protein called the TRP channel. TRP channels are found in fruit fly neurons responsible for sensing light. The fly TRP channel is the founding member of a family of related proteins in mammals that are essential for guiding certain nerves during development and for responding to stimuli including heat, taste and sound.

By shining bright light onto and recording electrical changes in single nerve cells in the fly eye, researchers found that neurons carrying a mutation in this gene cannot respond as well to light as compared to neurons carrying normal copies of this gene. In fact, the mutant neurons turn off their response to light four times faster than normal neurons. Because Lazaro helps fly TRP channels work at their maximum, it is possible that a Lazaro-like gene in mammals might also play a role in how well mammalian TRP channels work.

"These results have implications for understanding sensory signaling in mammals," says the study's senior author, Craig Montell, Ph.D., a professor in the biological chemistry department in the Institute of Basic Biomedical Sciences at Hopkins.

The researchers also discovered that alterations in this new gene greatly reduce the retinal degeneration caused by a different mutant. They named this new gene Lazaro after the novel Lazarillo de Tormes, in which the orphan boy Làzaro helps a blind man see.

Of th
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Male circumcision reduces risk of HIV transmission from women to men
2. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
3. New miniaturised chip dramatically reduces time taken for DNA analysis
4. New processing method reduces peanut allergenicity
5. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
6. Study finds that nutritionally enhanced rice reduces iron deficiency
7. Overfishing in inland waters reduces biodiversity and threatens health
8. Aspirin reduces cardiovascular risks in men and women -- but differently
9. Prenatal nicotine exposure reduces breathing response of newborns...
10. Heat-shock protein vaccine reduces alveolar bone loss
11. New compound reduces stroke damage
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New gene reduces retinal degeneration fruit flies

(Date:4/17/2014)... One day about eight years ago, Katia Silvera , ... her father were on a field trip in a mountainous ... they had never seen before. , Unable to identify it, ... The orchid turned out to be an unnamed species. So ... . , "Lophiaris" is the genus name, comprising about 40 ...
(Date:4/17/2014)... If a restaurant ... he can expect his premises to be trashed. Warnings like ... is enough to make restaurant owners pay up. Similarly, mafia-like ... in other birds, nests. If the host birds throw the ... destroying the entire nest. Consequently, it is beneficial for hosts ...
(Date:4/17/2014)... fragmentation of forests in the Amazon help create ... to rapid and widespread forest loss during drought ... findings show that forests in the Amazon could ... with forest fires lead to large-scale loss of ... assistant professor of geography, Penn State. , "We ...
Breaking Biology News(10 mins):Orchid named after UC Riverside researcher 2Orchid named after UC Riverside researcher 3Fear of the cuckoo mafia 2Fear of the cuckoo mafia 3Drought and fire in the Amazon lead to sharp increases in forest tree mortality 2Drought and fire in the Amazon lead to sharp increases in forest tree mortality 3
... An international team of investigators at Sanford-Burnham Medical Research ... Centre for Molecular Life Sciences and other organizations have ... also plays a significant role in Frank-Ter Haar syndrome ... on February 12 in the American Journal of ...
... CINCINNATI -- Scientists have discovered a molecular pathway that works ... may lead to new therapies for repairing injury in a ... week,s Proceedings of the National Academy of Sciences ... Children,s Hospital Medical Center and the Brigham & Women,s Hospital ...
... reveals that a common underlying mechanism is shared by ... complex defects in brain development and function. Rett syndrome ... Retardation, X-linked syndrome (ATR-X) have each been linked with ... DNA that make up chromosomes and control how genetic ...
Cached Biology News:Researchers identify mechanism for Frank-Ter Haar syndrome 2Scientists discover molecular pathway for organ tissue regeneration and repair 2A common thread links multiple human cognitive disorders 2
(Date:1/15/2014)... Rochester, NY (PRWEB) January 15, 2014 The ... cause a major disease. One of these latent viruses is ... is rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a chronic ... the theory, a study found that RA patients have high ...
(Date:1/15/2014)... (PRWEB) January 15, 2014 2013 was ... Scottsdale’s Brain State Technologies®. They saw continued independent research ... Center who were awarded a $1 million grant from ... in “Brain and Behavior” a peer reviewed journal, Amy ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider ... treatment of tinnitus. Patients listen to sound therapy that ... period of weeks to months, their tinnitus volume decreases. , ... Notched Music and Notched White Noise. Now, AudioNotch is pleased ...
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: ... 1360 Almshouse Road, Warrington, Pa. , Details: The ... to finding a cure for hepatitis B and improving the ... annual Crystal Ball on Friday, April 11 at Warrington Country ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... the Risks of DVT to Mark U.S. House of ... Coalition to Prevent DVT today announced the launch of ... deep-vein thrombosis (DVT) and to encourage dialogue between healthcare ... A customized recreational vehicle will visit hospitals and ...
... Christine Lawless, MD, has accepted the position as Medical ... medical education (CME), beginning March 2, 2009. Recognized as ... cardiology, Dr. Lawless recently completed her clinical tenure at ... she was Associate Professor of Internal Medicine and Co-Director ...
... March 10 WaferGen Biosystems, Inc. (OTC Bulletin ... analysis systems, today announced that Kumar Kastury, Ph.D., ... will present data on the company,s SmartChip(TM) Real-Time ... Anniversary Quantitative PCR Conference. The conference will ...
Cached Biology Technology:The Coalition to Prevent Deep-Vein Thrombosis (DVT) RV Tour Takes to the Road to Educate the Nation About the Importance of DVT Risk Assessment 2The Coalition to Prevent Deep-Vein Thrombosis (DVT) RV Tour Takes to the Road to Educate the Nation About the Importance of DVT Risk Assessment 3The Coalition to Prevent Deep-Vein Thrombosis (DVT) RV Tour Takes to the Road to Educate the Nation About the Importance of DVT Risk Assessment 4The Coalition to Prevent Deep-Vein Thrombosis (DVT) RV Tour Takes to the Road to Educate the Nation About the Importance of DVT Risk Assessment 5Former President of Sports Cardiology Consultants, LLC Christine Lawless, MD, MBA, ABCL, FACC, FACSM, Named Medical Director of CME Enterprise 2WaferGen to Present Data on SmartChip(TM) Real-Time PCR System at Cambridge Healthtech Institute's Quantitative PCR Conference 2WaferGen to Present Data on SmartChip(TM) Real-Time PCR System at Cambridge Healthtech Institute's Quantitative PCR Conference 3WaferGen to Present Data on SmartChip(TM) Real-Time PCR System at Cambridge Healthtech Institute's Quantitative PCR Conference 4
iNOS/NOS Type II Purified Anti-Mouse, Anti-Rat, Anti-Human clone Polyclonal, Isotype Rabbit Ig, 150 µg Consult technical datasheet for details....
...
... gradient system uses two Adept CE 4100 ... CE 4200 dual wavelength detector for added flexibility. ... by PowerStream data processing software and interface unit, ... The supplied analytical pumps may be substituted ...
... Highly nutritious peptone, used ... production of bacterial toxins, ... of bacteria with high ... Haemophilus, Neisseria, Pasteurella, Salmonella ...
Biology Products: