Navigation Links
New gene reduces retinal degeneration in fruit flies

Johns Hopkins researchers have discovered a gene in fruit flies that helps certain specialized neurons respond more quickly to bright light. The study, published in the April 4 issue of Current Biology, also has implications for understanding sensory perception in mammals.

In teasing apart the molecular interactions and physiology underlying light perception, the researchers studied a gene they dubbed "Lazaro" that is expressed 15 times higher in the fly eye than the rest of the fly head. They found that this gene is required for a second biochemical pathway that controls the activity of a protein called the TRP channel. TRP channels are found in fruit fly neurons responsible for sensing light. The fly TRP channel is the founding member of a family of related proteins in mammals that are essential for guiding certain nerves during development and for responding to stimuli including heat, taste and sound.

By shining bright light onto and recording electrical changes in single nerve cells in the fly eye, researchers found that neurons carrying a mutation in this gene cannot respond as well to light as compared to neurons carrying normal copies of this gene. In fact, the mutant neurons turn off their response to light four times faster than normal neurons. Because Lazaro helps fly TRP channels work at their maximum, it is possible that a Lazaro-like gene in mammals might also play a role in how well mammalian TRP channels work.

"These results have implications for understanding sensory signaling in mammals," says the study's senior author, Craig Montell, Ph.D., a professor in the biological chemistry department in the Institute of Basic Biomedical Sciences at Hopkins.

The researchers also discovered that alterations in this new gene greatly reduce the retinal degeneration caused by a different mutant. They named this new gene Lazaro after the novel Lazarillo de Tormes, in which the orphan boy Làzaro helps a blind man see.

Of th
'"/>

Source:Johns Hopkins Medical Institutions


Page: 1 2

Related biology news :

1. Male circumcision reduces risk of HIV transmission from women to men
2. Deficiency of growth hormone and IGF-1 reduces cancer and kidney disease, but creates other problems
3. New miniaturised chip dramatically reduces time taken for DNA analysis
4. New processing method reduces peanut allergenicity
5. Blocking the nerve receptor EP1 in mouse models reduces brain damage caused by stroke
6. Study finds that nutritionally enhanced rice reduces iron deficiency
7. Overfishing in inland waters reduces biodiversity and threatens health
8. Aspirin reduces cardiovascular risks in men and women -- but differently
9. Prenatal nicotine exposure reduces breathing response of newborns...
10. Heat-shock protein vaccine reduces alveolar bone loss
11. New compound reduces stroke damage
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New gene reduces retinal degeneration fruit flies

(Date:9/17/2014)... a great deal about complex social behavior by studying ... to teach too. , With their unusually large brains ... live in a complex social environment---not merely in a ... ants, but in a dynamic setting of alliances and ... mammals: dolphins, whales, primates, and social carnivores, like hyenas ...
(Date:9/16/2014)... American Menopause Society (NAMS) has published its key, ... womenon everything from hot flashes to heart disease. ... Recommendations for Clinical Care of Midlife Women," was ... Menopause . This is the first, comprehensive set ... women freely available to all clinicians who care ...
(Date:9/16/2014)... that we inherit certain traits from our parents that ... these genes play out by taking certain drugs or ... what a team of researchers at the Boston University ... of epigenetics research. , Epigenetics regulates gene expression ... histone proteins, which prevent permanent mutations or alterations within ...
Breaking Biology News(10 mins):Being social: Learning from the behavior of birds 2Epigenetic drugs: A hope to treat cancer resistance and reduce cancer relapse? 2Epigenetic drugs: A hope to treat cancer resistance and reduce cancer relapse? 3
... 29, 2010) -- Wind turbines may be one of ... larger they also get noisier, become more of an ... solution: ocean-based wind turbines. While offshore turbines already have ... where the tower extends directly into the seabed. That ...
... -- The U.S. Supreme Court ruled 5-4 Monday that a ... the ability to patent software should not be limited. ... the "machine or transformation" test is not the sole test ... however, cannot be patented. IEEE-USA was party to an ...
... the Arctic climate system may be more sensitive to greenhouse ... atmospheric carbon dioxide may be high enough to bring about ... University of Colorado at Boulder, the international study indicated that ... High Arctic during the Pliocene Epoch 2.6 to 5.3 million ...
Cached Biology News:Arctic climate may be more sensitive to warming than thought, says new study 2Arctic climate may be more sensitive to warming than thought, says new study 3Arctic climate may be more sensitive to warming than thought, says new study 4
(Date:9/18/2014)... OMICS Group International invites researchers, authors and academicians ... Access Week’ by actively contributing their research outcome ... from 20-26th October, 2014. , Pharmaceutical Sciences ... with a tremendous speed to provide improved medical ... is gearing with innovation and technological revolution to ...
(Date:9/18/2014)... and diabetes prevention, could actually hasten the development of ... in a surprising way: by changing the composition and ... of bacteria residing in our intestines. These findings, the ... today in Nature . Among other things, says ... who led this research together with Prof. Eran Segal ...
(Date:9/18/2014)... 18, 2014 Silicon-valley Electronic Data Capture ... Digitaliza TXT , the latest addition to Clinovo’s CRO ... Research Organization (CRO) Program, Clinovo further expands its global ... of ClinCapture training, we are now able to build ... Pulido. “We can also rely on Clinovo to fully ...
(Date:9/17/2014)... , Sept. 17, 2014  PDL BioPharma, Inc. (PDL) ... independent registered accounting firm, Ernst & Young LLP ("EY") that ... confirmed in a letter delivered to the Company on September ... September 16, 2014.  PDL has issued the ... have received a number of inquiries on the reason for ...
Breaking Biology Technology:Pharma and Omics Journals to Address Global Challenges during Open Access Week 2Pharma and Omics Journals to Address Global Challenges during Open Access Week 3Gut bacteria, artificial sweeteners and glucose intolerance 2Gut bacteria, artificial sweeteners and glucose intolerance 3Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 2Digitaliza TXT Joins Clinovo’s CRO Partnership Program, Bringing Its Open Source EDC System, ClinCapture to Latin America 3PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 2PDL BioPharma Issues Statement on Resignation of Ernst and Young as Corporate Auditors 3
Complement C1q subcomponent subunit C precursor. [Source:Uniprot/SWISSPROT;Acc:P02747] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Monoclonal Mouse Anti-Human Cytokeratin 16 (48 kD)...
Mouse monoclonal [CRC64] to Integrin alpha 2b + beta 3 ( Abpromise for all tested applications). Antigen: Human platelets Entrez Gene ID: 23295 Swiss Protein ID: P05106...
PFM8 Antibody...
Biology Products: