Navigation Links
New fruit fly protein illuminates circadian response to light

r sleep-wake cycle to the new light-dark schedule.

"The behavior of the mutant flies is similar to that displayed in a person who has prolonged jetlag," notes Sehgal. In search of answers to the mutant's defective circadian response to light, Sehgal and colleagues looked to the molecular details of the clock cells in the jetlag flies.

When a fruit fly is exposed to light, a photoreceptor called cryptochrome (CRY) transduces the light signal and kicks off a series of reactions within the clock cells of the brain. Under normal conditions, CRY will respond to light by binding to a protein called timeless (TIM). A second protein, a member of the F-box protein family, also binds to TIM, signaling TIM for cellular destruction.

Genetic analysis revealed that the jetlag flies possess a mutation in a gene that encodes a member of the F-box protein family. A closer examination of the protein produced by the mutated sequence led researchers to JET, a new protein within the F-box protein family.

"Since the degradation of TIM always happens in the presence of light, the animal associates the absence of TIM with daytime hours," explains Sehgal. The mutated JET protein reduces the light-dependent degradation of TIM and the circadian response to light.

Sehgal and others were able to reverse the behaviors in the jetlag flies by genetically replacing the mutated gene sequence with the normal sequence, which led to the production of the wild-type (control) JET protein. When the jetlag flies acquired the normal JET protein, regular TIM degradation took place and the fruit fly was better able to adjust to shifts in the light-dark cycle.

Future studies in the Sehgal lab will focus on continuing to identify other molecules required for the circadian response to light. "Some of the molecules required for the circadian light response in flies may be conserved in humans. Over time, we will have a better understanding of how the human clock res
'"/>

Source:University of Pennsylvania School of Medicine


Page: 1 2 3

Related biology news :

1. Master gene controls healing of skin in fruit flies and mammals
2. UI researcher studies deafness in fruit flies, humans
3. Gap-climbing fruit flies reveal components of goal-driven behaviors
4. Hormones and growth: The control of body size and developmental growth rate in fruit flies
5. Aloe vera coating may prolong freshness, safety of fruits and vegetables
6. Hanging baskets of sex and death help fruit growers
7. Researchers find gland that tells fruit flies when to stop growing
8. Past experience of pheromones induces dominant courtship behavior in fruit flies
9. A resetting signal keeps circadian rhythm on track in Drosophila fruit flies
10. Drunken elephants: The marula fruit myth
11. UCSD study finds anthrax toxins also harmful to fruit flies
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New fruit fly protein illuminates circadian response light

(Date:10/22/2014)... DENVER , Oct. 20, 2014  Leading identity ... years time half of the world,s population will have ... in Europe . Asia ... dominate the market accounting for more than 60% of ... Acuity,s report  -- "The Global National ...
(Date:10/18/2014)... patients with undiagnosed, suspected genetic conditions, a certain type ... molecular diagnostic yield than traditional molecular diagnostic methods, according ... study is being released to coincide with the American ... which sequences the protein­coding region of the genome (the ... a cell or organism), has been rapidly applied in ...
(Date:10/16/2014)... human body. Battles are won, lost or sometimes ... stalemate—known as tumor dormancy—can last up to 25 ... is poorly understood. , A new computational ... a Professor of Chemistry at Princeton University, may ... the switch to a malignant state. Published today ...
Breaking Biology News(10 mins):Half the World's Population Will Have Chip-Based National Electronic Identity (eID) Cards by 2018 2Study examines type of exome sequencing and molecular diagnostic yield 2Study examines type of exome sequencing and molecular diagnostic yield 3Modeling tumor dormancy 2
... Langone Medical Center,s Departments of Orthopaedic Surgery and Radiology ... detect subtle changes in joint cartilage microstructure and ... of early osteoarthritis (OA). By using these techniques during ... the management of the disease from eventual joint reconstruction ...
... Texas A&M Institute of Renewable Natural Resources have discovered fresh ... in Texas, according to a research associate with the institute. ... single individual of false spike "Quadrula mitchelli" with tissue still ... recently alive in the San Saba River ...
... SAN FRANCISCO, CAAugust 14, 2011Scientists at the Gladstone Institutes ... proteins that, when out of balance, can prevent the normal ... be important in some types of cancer. "The news, ... Nature Cell Biology , adds to the understanding of the ...
Cached Biology News:NYU Langone experts find MRI techniques can detect early osteoarthritis 2Researchers discover freshwater mussel species thought to be extinct 2Researchers discover freshwater mussel species thought to be extinct 3Researchers discover freshwater mussel species thought to be extinct 4Gladstone scientists offer new insight into the regulation of stem cells and cancer cells 2Gladstone scientists offer new insight into the regulation of stem cells and cancer cells 3
(Date:10/25/2014)... and NEW YORK , ... (OTCQB: ACCPD), formerly Access Pharmaceuticals, Inc. (ACCP), a ... announced it has implemented a 1-for-50 reverse split ... of trading on Friday, October 24, 2014. PlasmaTech,s ... under new CUSIP number 72754H109 and temporary ticker ...
(Date:10/25/2014)... , October 24, 2014 ... http://www.researchandmarkets.com/research/t5t5pd/the_global_market ) has announced the addition of ... Graphene And Other 2-D Nanomaterials "  report ... http://photos.prnewswire.com/prnh/20130307/600769) , ,CNTs and graphene are the ... to man, with a performance-per-weight greater than ...
(Date:10/22/2014)... 21, 2014 The Americas Inorganic ... refrigerants market in Americas with analysis and forecast ... the Americas Inorganic Refrigerants Market report, to get ... also provides a glimpse of the segmentation in ... by various tables and figures. , ...
(Date:10/22/2014)... WriteResult, LLC – a premier ... working with a team of researchers from Yale University’s ... Farming Collaborative to provide electronic questionnaire data collection through ... which started in May, aims to evaluate the impact ... exposure to and participation in urban agriculture to impact ...
Breaking Biology Technology:PlasmaTech Biopharmaceuticals, Inc. Announces Reverse Stock Split, Ticker Change and Launches New Corporate Website 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 2The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 3The Global Market for Carbon Nanotubes, Graphene and Other 2-D Nanomaterials 4The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 2The Americas Inorganic Refrigerants Market is estimated to grow to $71.6 million by 2018 - New Report by MicroMarket Monitor 3myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 2myPROpad™ Topic of Panel Discussion at the Yale Food Systems Symposium 3
... 22 Insmed Inc. (Nasdaq:,INSM), a developer of follow-on ... the recently disclosed temporary suspension,of NASDAQ,s minimum bid closing ... the Company now has until March 20, 2009 to ... a closing bid price of $1.00 or more for ...
... NicOx,S.A. (Euronext Paris: COX) today reported financial results for the nine,months ... quarter of 2008:, - Positive top-line results from the 302 ... co-primary efficacy endpoints at week-13 (p naproxcinod 750 ... non-inferiority to naproxen 500 mg bid at week-13 and 26. ...
... to Show Encouraging and Durable Anti-Tumor Activity and ... Dose Escalation Continues -, - Results Presented at ... Targets and ... MDVN ) today announced the presentation of new data from an,ongoing Phase ...
Cached Biology Technology:NASDAQ's Temporary Suspension of Minimum Bid Closing Price Rules Extends Insmed's Compliance Date to March 20, 2009 2NicOx Reports Results for the First Three Quarters of 2008 2NicOx Reports Results for the First Three Quarters of 2008 3NicOx Reports Results for the First Three Quarters of 2008 4NicOx Reports Results for the First Three Quarters of 2008 5NicOx Reports Results for the First Three Quarters of 2008 6NicOx Reports Results for the First Three Quarters of 2008 7NicOx Reports Results for the First Three Quarters of 2008 8NicOx Reports Results for the First Three Quarters of 2008 9NicOx Reports Results for the First Three Quarters of 2008 10Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients 2Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients 3Medivation Announces Presentation of 24-Week Clinical Data of MDV3100 in Castration-Resistant Prostate Cancer Patients 4
... The T2-04 is an ultra-compact pump available ... (T2-04 TH) and ideal for use in portable ... 7 slpm, this pump works well in environments ... weight, and compact size are critical., Offers ...
XA7 B6...
Curcumin is an extract of turmeric root with antioxidant, anti-tumor promoter, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages....
... The MEGAscript RNAi Kit ... of large mass amounts of ... in non-mammalian systems. The MEGAscript ... Ambions patented high-yield transcription technol-ogy ...
Biology Products: