Navigation Links
New finding points way to foiling anthrax's tricks

dents Rebecca J. Abergel and Trisha M. Hoette approached an anthrax research laboratory run by B. Rowe Byers, professor of microbiology at the University of Mississippi Medical Center, to obtain samples of anthrax siderophores. Because bacteria secrete siderophores, these molecules can be separated from the bacteria and studied without danger of infection.

Using these anthrax bacteria extracts, Abergel and Hoette isolated the two siderophores, bacillibactin and petrobactin, and showed that siderocalin tightly binds bacillibactin, preventing it from capturing iron from human cells. However, siderocalin does not prevent petrobactin from binding iron.

Interestingly, bacillibactin is very similar to siderophores in other bacteria, including enterobactin, which is produced by several pathogenic bacteria that live in the gut, such as Salmonella enterica and pathogenic strains of E. coli. These two bacteria also contain a second siderophore, aerobactin, with a molecular structure similar to petrobactin.

The researchers suggest that producing a second, stealth siderophore - petrobactin or aerobactin - that has a different molecular structure than bacillibactin and enterobactin may be a common response by bacteria to the human body's production of siderocalin.

The research could lead to anti-anthrax drugs that target petrobactin synthesis or iron-uptake, or to anthrax sensors that detect petrobactin, which is not known to occur in any other pathogenic bacteria.
'"/>

Source:University of California - Berkeley


Page: 1 2 3

Related biology news :

1. Surprising findings reported about iron overload
2. Liposome finding implies electrical effect on cell development
3. Evolution of life on Earth may hold key to finding life in outer space
4. LIAI scientists make major finding on potential smallpox treatment
5. Study findings offer potential new targets for antibiotics
6. The worlds deepest dinosaur finding - 2256 metres below the seabed
7. Protein finding could lead to treatment for inflammatory diseases
8. Oops! Researchers publish new findings on the brains response to costly mistakes
9. Inside rocks, implications for finding life on Mars
10. Biodiversity key to sustainable biofuel according to University of Minn. researchers findings
11. New findings offer more complete view of breast cancer gene mutations in US population
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New finding points way foiling anthrax tricks

(Date:7/2/2015)... 2015 Research and ... the "Natural Language Processing Market by Type ... Pattern & Image Recognition) - Worldwide Forecast to ... The key vendors occupying the market are 3M, ... Corporation, NetBase Solutions, SAS Institute Inc., Verint Systems ...
(Date:6/30/2015)... June 30, 2015 To bolster its efforts and ... Corp. announced today the addition of two new team members. ... board advisor and David Raviv will act as ... HYPR Corp.,s commitment to providing the most secure solutions for ... co-founded Layer 7 Technologies, a provider of security and ...
(Date:6/26/2015)... June 26, 2015 ATL Technology, LLC, a top ... specialties in single use solutions, headquartered in Springville, ... (a California corporation with locations in ... San Jose, Costa Rica ). This acquisition ... with ATL Technology,s existing facility in ...
Breaking Biology News(10 mins):Natural Language Processing Market by Type (Rule-Based, Statistical, and Hybrid), Technologies (Recognition, IVR, OCR, Pattern & Image Recognition) - Worldwide Forecast to 2020 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 2HYPR Corp. Expands Biometric Authentication Team with Enterprise All Stars 3ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2
... Medicine scientists have identified a component of the ... the virus to rapidly and successfully invade the ... Gregory Smith, associate professor in immunology and microbiology ... found that viral protein 1-2, or VP1/2, allows ...
... bacteria on their surfaces, not all of which cause disease. ... non-pathogenic bacteria, scientists report that these surface bacteria vary depending ... are published March 27 in the open access journal ... the University of Colorado, Boulder. The study focused on ...
... Sam Gandy, MD, PhD, of the Icahn School of Medicine ... working to reprogram skin cells into brain cells to gain ... the Consortium, Dr. Gandy is collaborating with Scott Noggle, PhD, ... Disease and Director of the New York Stem Cell Foundation ...
Cached Biology News:How herpesvirus invades nervous system 2Mount Sinai leads global program using stem cells to accelerate cures for Alzheimer's disease 2
(Date:7/29/2015)... July 29, 2015 ... the addition of the "Global Biosimilars Market, ... The Global Biosimilars Market, 2015 - ... rapidly growing biosimilars market. With the blockbuster biologics ... minimize costs, biosimilars are being viewed as viable ...
(Date:7/29/2015)... 2015  Therapath Neuropathology ( www.Therapath.com ), a ... VA and Military Medical centers both domestically and ... and Sweat Gland Nerve Fiber Density (SGNFD) for ... ). Demonstration of a reduction ... punch skin biopsy is a highly sensitive and ...
(Date:7/29/2015)... NJ (PRWEB) , ... July 29, 2015 , ... The ... approval of combination products , in particular, drug/device combinations. The current system received ... by the Initiative for Patient Centered Innovation (iPCI) of Fairleigh Dickinson University’s ...
(Date:7/29/2015)... ... July 29, 2015 , ... Finding gooey or crusty material in the ... there are a considerable number of terms in popular use to describe it, ophthalmologists ... a mixture of mucus, blood cells, skin cells and dust, but until now there ...
Breaking Biology Technology:Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 2Global Biosimilars Market to 2025: Monoclonal Antibodies (mAbs), Insulin, Interferons, G-CSF/ GM-CSF, Erythropoietins and Others 3Neuropathology services for VA and Military health systems 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 2Third Medical Innovation Impact Index Issued by Fairleigh Dickinson University’s Initiative for Patient-Centered Innovation (iPCI) 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 2What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 3What Are ‘Eye Crusties’ Made Of? uBiome Invites Citizen Scientists to Find Out 4
... Wis. The nation's dysfunctional healthcare system may undermine ... of electronic health records, according to a featured speaker at ... Jeff Grossman Dr. Jeff Grossman, president and CEO of ... on the role of IT in healthcare delivery. As he ...
... Doyle told a gathering of health professionals attending the ... of the first state to have a fully integrated ... to overcome barriers. , ,Speaking before a group of ... on the state's eHealth Initiative, Doyle said those barriers ...
... liability in identity theft cases was spelled out during ... and healthcare providers got a real sense of what ... hypothetical case of identity theft from an orthopedic hospital, ... how much trouble healthcare organizations can find themselves in ...
Cached Biology Technology:U.S. health system could undermine EHR progress 2U.S. health system could undermine EHR progress 3Doyle asks health professionals to overcome barriers 2Doyle asks health professionals to overcome barriers 3Managing the nightmare of identity theft 2Managing the nightmare of identity theft 3Managing the nightmare of identity theft 4
... This DuoSet ELISA Development kit contains the ... sandwich ELISAs to measure natural and recombinant ... supernates and serum. Each kit contains sufficient ... 96-well plates, provided that the following conditions ...
HIV-1 TAT (vN-21)...
Presenilin-1, N-terminus....
Request Info...
Biology Products: