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New factor implicated in allergy and asthma attacks

duced by this enzyme.

Past studies report contradictory results concerning the effectiveness of antioxidants such as Vitamin C in reducing airway inflammation. Those contradictions, Dharajiya pointed out, are resolved by the evidence that pollen brings both NADPH oxidase and antigens into the airways, making airway antioxidant levels the critical factor. "The antioxidant has to be there when the person is exposed, and if the antioxidant level is not sufficient, it won't eliminate this oxidative insult."

Because antioxidant compounds are quickly metabolized in the lungs and airways, it may be necessary to deliver them every few hours via an inhaler. Boldogh and Sur suggested that it is now important to develop longer-lived antioxidant. "If we can find an antioxidant with a longer half-life, it could be really very effective in asthma and allergy treatment and also prevention," Boldogh said.


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Source:University of Texas Medical Branch at Galveston


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