Navigation Links
New evidence supports century-old theory of cancer spread

A Yale School of Medicine study in the December issue of Lancet Oncology challenges mainstream oncology researchers to consider tumor cell hybridization with white blood cells as a major reason that cancer metastasizes or spreads to other parts of the body.

"Cancer cells exhibit a remarkable number of traits normally attributed to white blood cells known as macrophages, including the ability to migrate to lymph nodes and distant organs and to form a new blood supply. Our data indicate that they do this by hybridizing with macrophages," said lead author John Pawelek, research affiliate in the Department of Dermatology at Yale School of Medicine and a member of Yale Cancer Center.

Pawelek said the idea of white blood cells hybridizing with tumor cells is not new. In the early 1900's the German pathologist Otto Aichel proposed that metastasis is caused by cancer cells fusing with macrophages. "There is now evidence to support all aspects of his proposition," said Pawelek. "Macrophages are among the most motile cells we have. By co-opting the macrophage's ability to move, the hybrid is very different from the original cancer cell. It is able to migrate away from the primary site of tumor formation and take up residence in other areas of the body while it continues to divide."

Working for more than a decade with a diverse team of scientists at the Yale School of Medicine and other research centers, Pawelek concludes that there is now sufficient evidence for Aichel's proposal to be taken seriously by the research community. Pawelek's group began testing the theory in 1993, when they created hybrids in the lab by fusing mouse melanoma cells with mouse macrophages.

"Their behavior was astonishing," said Pawelek. "In culture dishes, fused cells were extraordinarily motile compared to unfused melanoma cells. They spread rapidly when implanted in mice. Even though the idea is virtually unknown to cancer researchers today, many scientists worke
'"/>

Source:Yale University


Page: 1 2

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. Light therapy may combat fungal infections, new evidence suggests
3. Researchers find first evidence of venom system in extinct mammal
4. Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
5. Oldest dated evidence of cattle in southern Africa found
6. SLU researchers uncover direct evidence on how HIV invades healthy cells
7. Same-sex mating by fungi spawned infection outbreak, evidence suggests
8. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
9. Why we give: New study finds evidence of generosity among our early human ancestors
10. New evidence questions the simple link between prion proteins and madcow disease
11. UCSD biologists find new evidence for one-way evolution
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New evidence supports century old theory cancer spread

(Date:3/24/2015)... Research and Markets ( http://www.researchandmarkets.com/research/hdgz7h/global_iris ) ... Recognition Market 2015-2019" report to their offering. ... to grow at a CAGR of 23.5 percent over ... present scenario and the growth prospects of the Global ... the market size, the report considers the revenue generated ...
(Date:3/24/2015)... BEACH GARDENS, Fla. , March 24, 2015 ... biometric identity management solutions, today announced that its ... premium clothing accessory retailer Goorin Bros . ... The Crossmatch biometrics-based solution secures access to the ... from the increased risk of data breaches. ...
(Date:3/23/2015)... ANGELES , March 23, 2015  In the ... Federal fraud case conviction losses. This figure accounts for ... which, according to The Nilson Report, exceeds $11 billion ... investigative tool after a crime has occurred. Investor ... and polygraph expert Joe Paolella partnered to ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... French . Toronto (June 5, 2009) ... to announce another measure to address the H1N1 flu virus. ... network focused on pandemic vaccine evaluation. The network will strengthen ... pandemic influenza vaccine and vaccination programs. The network was ...
... may shape the human genome much more slowly than ... within and among continents, the expansions and contractions of ... heavily influenced the distribution of genetic variations in populations ... from the Howard Hughes Medical Institute, the University of ...
... EAST LANSING, Mich. A pair of Michigan ... $400,000 for their cardiovascular research projects as part of ... The money, from the National Institutes of Health ... to preserve and create jobs in Michigan while also ...
Cached Biology News:Government of Canada announces funding for research on the H1N1 flu virus 2Geography and history shape genetic differences in humans 2MSU researchers receive $400,000 in first wave of stimulus funding 2
(Date:5/4/2015)... 2015 /PRNewswire/ - JSS Medical Research Inc., a Montreal ... concluded the acquisition of Max Neeman International (MNI), with head office ... are located in Ahmedabad, Bangalore , ... US subsidiary, a regional office is located North Carolina, ... by the recent equity investment transaction into JSS with Capital Croissance ...
(Date:5/4/2015)... Israel , May 4, 2015  Tikcro Technologies ... its annual report on Form 20-F for the fiscal ... and Exchange Commission ("SEC"). The annual report on Form ... development of antibodies in the area of cancer immune ... superior qualities of high specificity and binding in targeting ...
(Date:5/4/2015)... TORONTO , May 4, 2015 /PRNewswire/ - ... its partners are pleased to announce the formation ... focussed on developing treatments for cancer that harness ... company represents a unique collaboration between the Children,s ... (CHEO) Research Institute, McMaster University, the Ontario Institute ...
(Date:5/4/2015)... Achieved primarily through a proprietary paraffin and stain ... 100x better detail than the industry standard. But ... microscopy methods, it needed another medium to measure its ... of reference because it represents the highest standard of ... earliest discovery days of Ultralight Histology was to reverse ...
Breaking Biology Technology:JSS Medical Canada widens its global presence across Asia/Pacific region 2JSS Medical Canada widens its global presence across Asia/Pacific region 3JSS Medical Canada widens its global presence across Asia/Pacific region 4Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3
... any tissue with the Big Blue transgenic,rodent ... Barry W. Glickman ,Centre for Environmental Health, University of ... transgenic rodent mutation,assay,* which carries the ... vector, it is easy to study mutations in male,and ...
... and efficient PCR cloning with pcmv-script PCR cloning kit ... Tim Sanchez Quinn,Lu ,Stratagene Cloning Systems, Inc. , ... cloning,strategy by introducing a new vector for ... The pcmv-script PCR,cloning kit ...
... reagent is effective with a wide variety ... ,Genetic Applications LLC , LipoTAXI ... delivery of foreign DNA into mammalian,cells. In this study, ... conditions for transfecting a reporter plasmid in three common ...
Cached Biology Technology:Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer 2Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer 3Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer 4Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer 5Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer 6Tissue Specificity for Mutation Parallels Tissue Specificity for Cancer 7Mammalian Expression Vector for Efficient Cloning of PCR Fragments 2Mammalian Expression Vector for Efficient Cloning of PCR Fragments 3Mammalian Expression Vector for Efficient Cloning of PCR Fragments 4A Comparison Study of Lipid Tranfection Reagents in A549, NIH 3T3 and COS-7,Cell Lines 2A Comparison Study of Lipid Tranfection Reagents in A549, NIH 3T3 and COS-7,Cell Lines 3
Porcine Serum US Origin 6 Months or Older...
SEQUENASE PCR PRODUCT PRE-SEQU, 1 EA. Category: SEQUENASE....
... off the clot from fasted Cynomolgus monkeys of mixed ... Anticoagulants: N-02: Citrate N-04: ... Potassium Oxalate N-10: EDTA (Na) N-03: ... CPD N-09: K3EDTA N-11: Heparin ...
adult...
Biology Products: