Navigation Links
New evidence supports century-old theory of cancer spread

A Yale School of Medicine study in the December issue of Lancet Oncology challenges mainstream oncology researchers to consider tumor cell hybridization with white blood cells as a major reason that cancer metastasizes or spreads to other parts of the body.

"Cancer cells exhibit a remarkable number of traits normally attributed to white blood cells known as macrophages, including the ability to migrate to lymph nodes and distant organs and to form a new blood supply. Our data indicate that they do this by hybridizing with macrophages," said lead author John Pawelek, research affiliate in the Department of Dermatology at Yale School of Medicine and a member of Yale Cancer Center.

Pawelek said the idea of white blood cells hybridizing with tumor cells is not new. In the early 1900's the German pathologist Otto Aichel proposed that metastasis is caused by cancer cells fusing with macrophages. "There is now evidence to support all aspects of his proposition," said Pawelek. "Macrophages are among the most motile cells we have. By co-opting the macrophage's ability to move, the hybrid is very different from the original cancer cell. It is able to migrate away from the primary site of tumor formation and take up residence in other areas of the body while it continues to divide."

Working for more than a decade with a diverse team of scientists at the Yale School of Medicine and other research centers, Pawelek concludes that there is now sufficient evidence for Aichel's proposal to be taken seriously by the research community. Pawelek's group began testing the theory in 1993, when they created hybrids in the lab by fusing mouse melanoma cells with mouse macrophages.

"Their behavior was astonishing," said Pawelek. "In culture dishes, fused cells were extraordinarily motile compared to unfused melanoma cells. They spread rapidly when implanted in mice. Even though the idea is virtually unknown to cancer researchers today, many scientists worke d on it in the 20th century. From the late 1960's up to today there have been many reports of tumor hybrids."

"Aichel implored future scientists to study cancer cells 'from all angles' for evidence of hybridization," Pawelek added. "It is remarkable that a century later we are doing just that. Were he alive today, Aichel would likely be both surprised and gratified, even though it might seem to be taking a rather long time."


'"/>

Source:Yale University


Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. Light therapy may combat fungal infections, new evidence suggests
3. Researchers find first evidence of venom system in extinct mammal
4. Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
5. Oldest dated evidence of cattle in southern Africa found
6. SLU researchers uncover direct evidence on how HIV invades healthy cells
7. Same-sex mating by fungi spawned infection outbreak, evidence suggests
8. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
9. Why we give: New study finds evidence of generosity among our early human ancestors
10. New evidence questions the simple link between prion proteins and madcow disease
11. UCSD biologists find new evidence for one-way evolution
Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/2/2017)... 2017   TapImmune, Inc. (NASDAQ: ... in the development of innovative peptide and gene-based ... and metastatic disease, announced today it has successfully ... a second clinical lot of TPIV 200, the ... The manufactured vaccine product will be used to ...
(Date:1/31/2017)... 31, 2017  Spero Therapeutics, LLC, a biopharmaceutical ... treatment of bacterial infections, today announced it has ... from Pro Bono Bio Ltd (PBB) to bolster ... resistant forms of Gram-negative bacteria.   The assets acquired ... a PBB group company. "The acquisition ...
(Date:1/25/2017)... YORK , Jan. 25, 2017 The ... Access Management (IAM) lifecycle is comprised of a ... for the purpose of maintaining digital identities and ... resources and applications. There are significant number of ... from time to time by optimizing processes and ...
Breaking Biology News(10 mins):
(Date:2/17/2017)... 17, 2017  If only one in every ... mutation-conferring resistance to chemotherapy, thousands of cancer cells ... focused on finding these mutations in ever-smaller subpopulations ... tumor DNA in blood — to guide treatment ... Unfortunately, however, detecting these genetic anomalies may ...
(Date:2/16/2017)... MI (PRWEB) , ... February 16, 2017 , ... Avomeen ... p.m. The event will be held at Avomeen Analytical Services (4840 Venture Dr., ... a MichBio member organization. They provide an opportunity to interact with peers, make new ...
(Date:2/16/2017)... Feb. 16, 2017  ArmaGen, Inc., a privately ... to treat severe neurological disorders, today reported preliminary ... AGT-181, the company,s investigational therapy for the treatment ... mucopolysaccharidosis type I, or MPS I). The initial ... study, presented today at the 13 th ...
(Date:2/16/2017)... February 16, 2017 Patient ... of innovative telemedicine application, new and leading edge ... experiencing a boom worldwide. The healthcare sector as ... technologies, services and new therapies for companies such ... RHT), Cellectar Biosciences, Inc. (NASDAQ: CLRB ...
Breaking Biology Technology: