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New evidence questions the simple link between prion proteins and madcow disease

urnal Dr Nicole Sales of the Department of Infectology, at the Scripps Research Institute Jupiter, Florida, suggests that one possible explanation that keeps with the prion hypothesis is that infection occurs as PrPs are absorbed in the mouth, rather than in the gut.

Dr Jeffrey, however, is not convinced by this argument. "Were infection to be acquired from the mouth then the first tissues to accumulate infectivity would be lymph nodes in the throat or the tonsils. But we don't tend to see this in animals, and have no reason to believe it would be different in humans," comments Jeffrey.


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Source:John Wiley & Sons, Inc.


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