Navigation Links
New evidence questions the simple link between prion proteins and madcow disease

While newly published research confirms that under laboratory circumstances prion-protein can be absorbed across the gut, it also shows that this is unlikely to occur in real life. In addition, the results show that the places in the gut that do take up these disease-associated proteins are different from the locations where infectivity is known to be amplified. The findings will be published in the Journal of Pathology.

Since the outbreak of BSE in cattle and vCJD in humans, scientists have struggled to make sense of how an abnormal variation of a normal protein can trigger an infectious disease. Some are questioning whether this simple relationship exists at all. This paper adds new evidence that can inform the debate.

Firstly, it is known that individual people and animals have different levels of genetic susceptibility to this group of diseases, but no one knows how this resistance is achieved. One option is that resistant people do not absorb the disease-associated prion protein (PrP) from their guts.

To test this, the researchers worked with 50 sheep, with different degrees of genetic resistance to scrapie ?the sheep form of the disease. When they injected material containing abnormal prion protein (PrP) into the sheep's gut, it was equally absorbed by all sheep.

"This clearly shows that resistance is not achieved by blocking uptake of abnormal proteins from the gut ?it must be achieved by some other mechanism," says lead author Dr Martin Jeffrey.

Secondly, they looked in more detail at the route of absorption in the gut. Using surgically modified sheep, they loaded a small area of the gut with a fluid mixture containing 0.5 grams of scrapie infected brain containing a large amount of the disease specific variant of the PrP protein and watched how it was taken up. They saw the abnormal PrP was rapidly taken up by finger-like projections called villi and passed in to the lymph. It was not, however, taken up by structur
'"/>

Source:John Wiley & Sons, Inc.


Page: 1 2 3

Related biology news :

1. Genome of deadly amoeba shows surprising complexity, evidence of lateral gene transfer
2. Light therapy may combat fungal infections, new evidence suggests
3. Researchers find first evidence of venom system in extinct mammal
4. Scientists find evidence of catastrophic sand avalanches, sea level changes in Gulf of Mexico
5. Oldest dated evidence of cattle in southern Africa found
6. SLU researchers uncover direct evidence on how HIV invades healthy cells
7. Same-sex mating by fungi spawned infection outbreak, evidence suggests
8. Team led by Carnegie Mellon University scientist finds first evidence of a living memory trace
9. Why we give: New study finds evidence of generosity among our early human ancestors
10. New evidence supports century-old theory of cancer spread
11. UCSD biologists find new evidence for one-way evolution
Post Your Comments:
(Date:7/11/2014)... many fires burning in eastern New South Wales, Australia ... , At 03:35 UTC on July 11 (12:35 p.m. ... passed over eastern New South Wales (NSW), the Moderate ... image of the region and spotted smoke (light brown) ... thermal bands, are outlined in red. , The New ...
(Date:7/11/2014)... Cell scientists have set a "mouse TRAP" to capture ... a recent study published in the Journal of ... a technique called TRAP to extract cellular and genetic ... by scientists at the Rockefeller Institute for Medical Research ... the protein-making machinery, or ribosomes, of the cell type ...
(Date:7/11/2014)... international team of researchers, including scientists from the Max ... a reported a major step in understanding photosynthesis, the ... maintains the oxygen in its atmosphere and which is ... earth. , The researchers report the first direct ... namely the step in which a specific protein complex, ...
Breaking Biology News(10 mins):A first direct glimpse of photosynthesis in action 2
... N.C. Feb. 28, 2013 Researchers at Wake ... special population of adult stem cells in bone marrow ... intestine and produce intestinal cells, suggesting their potential to ... (IBD). Up to 1 million Americans have IBD, ...
... -- In a new study, biologists will investigate the ... has killed a record number of frogs, toads and ... received a $595,000 grant from the National Science Foundation ... and a fungus called Batrachochytrium dendrobatidis (Bd). ...
... decimate the normal intestinal microbiota, which may never ... the GI tract vulnerable to being colonized by ... New York, NY, and Centro Superior de Investigacin ... normal microbial diversity largely eliminated vancomycin-resistant enterococci (VRE) ...
Cached Biology News:Research supports promise of cell therapy for bowel disease 2Biologists explore link between amphibian behavior and deadly disease 2Biologists explore link between amphibian behavior and deadly disease 3Good bacteria may expunge vancomycin-resistant bacteria from your gut 2
(Date:7/10/2014)... 10, 2014 Unraveling life’s mysteries can ... The Archer Family purchased a DNA test ... ended up with a lifetime of memories, sharing, and ... family members’ DNA genuinely brought the family closer together. ... deeper into genetic history and prior to taking the ...
(Date:7/10/2014)... Ind. , July 10, 2014 /PRNewswire/ ... its use of capnography for respiratory monitoring ... group of healthcare leaders in embracing state-of-the-art ... how effectively patients are breathing and can ... occurs. By measuring the amount of carbon ...
(Date:7/10/2014)...   Ceres, Inc . (Nasdaq: CERE ... financial results for the three months ended May 31, ... Ceres reported that the company and its customers ... season in Brazil, which concluded in June, despite dry ... areas for part of the growing season. Yields of ...
(Date:7/10/2014)... the basis of psychiatric disorders has been extremely challenging ... risk but are insufficient to cause disease. Now investigators ... Press journal Cell Stem Cell describe a ... risks interact with other risk factors or environmental exposures ... research pinpoints a genetic variant that may predispose individuals ...
Breaking Biology Technology:Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5Franciscan St. Anthony Health-Crown Point Underscores Patient Safety Commitment Through Expanded Use of Capnography 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 2Ceres Announces Fiscal Third Quarter 2014 Financial Results 3Ceres Announces Fiscal Third Quarter 2014 Financial Results 4Ceres Announces Fiscal Third Quarter 2014 Financial Results 5Ceres Announces Fiscal Third Quarter 2014 Financial Results 6Ceres Announces Fiscal Third Quarter 2014 Financial Results 7Ceres Announces Fiscal Third Quarter 2014 Financial Results 8Ceres Announces Fiscal Third Quarter 2014 Financial Results 9New strategy could uncover genes at the root of psychiatric illnesses 2
... Suzanne DeCann visits the University of Wisconsin-Eau Claire ... to pick up her newly earned Master of Business Administration ... the first 11 UW-Eau Claire students to earn their MBAs ... shell get her first real look at the campus and ...
... South Carolina , a health insurance provider that ... its evolving document communication needs by designating two ... Esker DeliveryWare Platform and Esker Fax respectively provide ... fax. , ,BlueCross BlueShield has enlisted Esker software ...
... Middleton-based provider of testing instruments used in support of ... announced the purchase of Masthead Imagings assets. ... are the PIPSpro software package and QC-3 phantom, for ... PIPSpro software displays, enhances and analyzes portal images and ...
Cached Biology Technology:UW-Eau Claire graduates first online MBAs 2UW-Eau Claire graduates first online MBAs 3Blue Cross BlueShield of South Carolina implements Esker solutions 2Standard Imaging acquires Canadian PIPSpro radiation treatment technologies 2
Based on Silica membrane matrix beads. The kit is designed for the purification of DNA (20 bp - 100 bp) from TAE/TBE agarose gels. Run time is approximately 45 minutes....
... DNA and Gel Band Purification Kit, 100. For ... and DNA fragments (0.1-10 kb) from solution and ... DNA fragments from solution in as little as ... in 15 min.Prepacked glass fiber matrix columns provide ...
These disposable button tethers are designed for rat infusion studies lasting more than 2 weeks. After one to two weeks the subcutaneous tissue will grow into the Dacron mesh, making the sutures irre...
Newborn Bovine Serum Heat-Inactivated...
Biology Products: