Navigation Links
New drug could reduce tissue damage after heart attack

A study led by UCL (University College London) scientists has designed a new drug that inhibits the adverse effects of C reactive protein (CRP), a protein that contributes to tissue damage in heart attacks and strokes. The findings, published in the journal Nature, suggest that targeting CRP may produce both immediate and long-term clinical benefits following a heart attack.

CRP is normally present at trace levels in the blood but its concentration increases sharply in almost all diseases including trauma, infection, strokes and chronic illnesses such as rheumatoid arthritis and Crohn's disease. CRP levels also rise dramatically after a heart attack. Patients with the greatest and most persistent increases in CRP concentration suffer higher mortality, and CRP is always deposited in and around the damaged heart tissue.

Inflammation contributes significantly to the extent of heart attack damage and this can be exacerbated by CRP. The UCL team has previously shown that human CRP increases the severity of damage in experimental models of heart attack and stroke. This first identified CRP as a valid therapeutic target. The present collaborative study has now rationally designed a potent small molecule inhibitor of CRP.

The new compound, bis(phosphocholine)-hexane, is bound by CRP, inhibits all CRP functions in the test tube, and blocks the tissue damaging effect of CRP in an experimental heart attack model.

Professor Mark Pepys, of the UCL Centre for Amyloidosis and Acute Phase Proteins, whose work on CRP has been supported by the Medical Research Council since 1979, says: "Although heart attacks are responsible for about one third of all deaths in developed countries, most patients survive a first heart attack. However, if they have a large scar, patients go on to develop heart failure which is eventually fatal. Reducing the immediate damage is thus critically important.

"We had previously invented a new mechanism of drug
'"/>

Source:University College London


Page: 1 2

Related biology news :

1. Protein discovery could unlock the secret to better TB treatment
2. Tiny particles could solve billion-dollar problem
3. First atlas of key brain genes could speed research on cancer, neurological diseases
4. Discovery of key proteins shape could lead to improved bacterial pneumonia vaccine
5. A comprehensive response to HIV could prevent 10 million AIDS deaths in Africa by 2020
6. How the environment could be damaging mens reproductive health
7. Dead zone area in Gulf could be increasing, researchers say
8. Growth in biomass could put US on road to energy independence
9. Nano-bumps could help repair clogged blood vessels
10. Researchers develop assay that could be applied to drug screening
11. Currents could disrupt ocean food chain
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New drug could reduce tissue damage after heart attack

(Date:7/22/2014)... published research in the Journal of ... dopamine signaling and dopamine transporter function are ... early-onset Parkinsonism and attention deficit hyperactivity disorder ... a critical basis for further exploration of ... function contribute to brain disorders" said Michelle ...
(Date:7/22/2014)... 14, 2014, by lightning from a weather system that moved ... fires: Stokes Fire, Gold Hikes Fire, French Creek Fire and ... now one larger fire. The fires are burning in timber ... acres in size. The present fire situation continues to ... firefighter safety is the priority on the Carlton Complex fires. ...
(Date:7/22/2014)... new study that examined the survival rates of ... in commercial longline fishing operations found large differences ... thresher, dusky, and scalloped hammerhead being the most,vulnerable. ... of Miami (UM) Rosenstiel School of,Marine and Atmospheric ... and Policy, provides,new information to consider for future ...
Breaking Biology News(10 mins):The dopamine transporter 2The dopamine transporter 3New study reveals vulnerability of sharks as collateral damage in commercial fishing 2
... with high levels of the virus associated with cervical ... 27 times, according to a study published in the ... , Anthony Gunnell, a medical biostatistician and epidemiologist ... the medical exams of women with non-invasive cervical cancer ...
... parasite on earth: It infects hundreds of species of ... ability to overcome the numerous challenges of infecting and ... long intrigued scientists, and now researchers at the Stanford ... proteins critical to its ability to thrive. , The findings ...
... of heme oxygenase-1 (HO-1), an antioxidant that protects against ... tissue injury), become elevated in the lungs of chronic ... for the disease. , These results appear in the ... of Respiratory and Critical Care Medicine, published by the ...
Cached Biology News:High HPV concentrations combined with smoking significantly raise risks of cervical cancer 2High HPV concentrations combined with smoking significantly raise risks of cervical cancer 3Stanford discovery may help predict when toxoplasma can be deadly 2Stanford discovery may help predict when toxoplasma can be deadly 3Antioxidant protects against lung damage in silicosis 2
(Date:7/22/2014)... LAKES, N.J. , July 22, 2014 The ... BDX ) has declared a quarterly dividend of ... to holders of record on September 9, 2014. The indicated ... About BD BD is a leading medical technology ... of the world,s most pressing and evolving health needs. Our ...
(Date:7/22/2014)... Terry Baughn, a senior lecturer in mechanical engineering at ... Engineer of the Year by the North Texas section ... ASME has more than 130,000 members in 158 countries ... technology to assist the engineering community, benefiting the world. ... Texas Society of Professional Engineers honors banquet. Baughn retired ...
(Date:7/22/2014)... 22, 2014 Automated cell culture systems ... of cell culture. They allow production of optimum cells ... researchers in drug discovery and industries and biopharmaceutical companies. ... production, iPSC research, cryobanking, cell-based assays, and cellular expression ... , Analysts forecast the Global Cell Culture market ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 OHAUS ... portable, and mechanical balances and scales, proudly announces ... has won Laboratory Equipment magazine’s 2014 “Readers' Choice” ... second consecutive year the Explorer was voted the ... annual Readers’ Choice Awards celebrates “excellence in product ...
Breaking Biology Technology:UT Dallas professor receives Engineer of the Year award 2Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 2Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 3Global Cell Culture Market to Grow at 10.27% CAGR by 2018 Forecasts a New Research Report ReportsnReports.com 4OHAUS Explorer Voted “Best Balance” in Laboratory Equipment’s 2014 Readers’ Choice Awards 2
... Verenium,Corporation (Nasdaq: VRNM ), a leading developer ... development of high-performance specialty,enzymes, announced today that John ... Financial Officer, will present at the upcoming,Piper Jaffray ... to begin at 10:00 a.m. ET on Wednesday, ...
... and Reduce the ... Conn., Feb. 13 VION,PHARMACEUTICALS, INC. (Nasdaq: VION ) ... Omni Hotel in New Haven, Connecticut today at,10:00 Eastern Time., ... the,Company,s Restated Certificate of Incorporation to:, -- effect ...
... Company Posts Fourth Quarter EPS of $0.37, Up 16% -, - For ... Up 41%; Total Revenues and Product ... Income Growth in Four Years, ... $1.72 -, SAN DIEGO, Feb. 13 Gen-Probe Incorporated,(Nasdaq: GPRO ...
Cached Biology Technology:Verenium Corporation to Present at Piper Jaffray Clean Technology & Renewables Conference 2Verenium Corporation to Present at Piper Jaffray Clean Technology & Renewables Conference 3Vion Pharmaceuticals Holds Special Meeting of Stockholders 2Vion Pharmaceuticals Holds Special Meeting of Stockholders 3Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 2Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 3Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 4Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 5Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 6Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 7Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 8Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 9Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 10Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 11Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 12Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 13Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 14Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 15Gen-Probe Reports Strong Financial Results for Fourth Quarter and Full Year 2007 16
The S. cerevisiae Hansen strains are the parental yeast strains from which the deletions were derived....
The Hybrid Hunter Yeast Two-Hybrid System uses the activation of reporter genes to indicate positive protein-protein interactions. Two reporters are used an auxotrophic marker and lacZ....
IHC detection kit for PCNA in cells and tissues...
... HandyStep electronic from BRAND adds ergonomics ... is the only electronic, motor-driven repeating ... tips, including BRAND PD-Tip syringe tips, ... Dispenser Tips,and VWRbrand Combi-Syringes. Select virtually ...
Biology Products: