Navigation Links
New details on how the immune system recognizes influenza

Drawing upon a massive database established with funds from the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health (NIH), scientists have completed the most comprehensive analysis to date of published influenza A virus epitopes--the critical sites on the virus that are recognized by the immune system. The findings, reported by researchers at the La Jolla Institute for Allergy and Immunology (LIAI), are being published online this week by the journal Proceedings of the National Academy of Sciences.

The study should help scientists who are designing new vaccines, diagnostics and immune-based therapies against seasonal and pandemic influenza because it reveals in molecular detail exactly where the immune system focuses on the viruses. Although the complete molecular structures of essentially all major strains of influenza viruses are known, immune responses concentrate on limited regions of certain parts of the virus, and these regions must be identified as immune epitopes by research studies. The LIAI team found that while there were hundreds of shared epitopes among different virus strains, including the avian H5N1 virus, only one has been published that appears ideal for multi-strain vaccines. Information on shared protective epitopes is important for developing influenza vaccines that can provide broad protection against multiple strains of the virus.

"This study is interesting for what it shows we know and do not know," says NIAID Director Anthony S. Fauci, M.D. "It reveals many gaps in our knowledge of influenza viruses and indicates where we need to focus our attention."

The analysis drew upon a much larger effort called the Immune Epitope Database and Analysis Resources Program, which began in 2004 after NIAID awarded LIAI a $25 million contract to create a single repository of immune epitopes from critical disease-causing microbes, including agents that might be used in a bioterroris
'"/>

Source:NIH/National Institute of Allergy and Infectious Diseases


Page: 1 2 3 4

Related biology news :

1. Nonlinear Dynamics announces more details of its global partnership with PerkinElmer
2. Researcher uncovers details of how cancer spreads
3. Research details how a virus hijacks cell signals to cause infection
4. Study reveals details of mussels tenacious bonds
5. Study details hepatitis C ability to block immune system response
6. Researchers discover new details about HIV-1 entry and infection
7. Fox Chase Cancer Center scientists identify immune-system mutation
8. Genetically modified natural killer immune cells attack, kill leukemia cells
9. Studies reveal methods viruses use to sidestep immune system
10. Jumping gene helps explain immune systems abilities
11. Scientists solve structure of key protein in innate immune response
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New details how the immune system recognizes influenza

(Date:12/17/2014)... 15, 2014  HITLAB SM announced today ... audit to confirm its adherence to current U.S. ... enables HITLAB to conduct regulated smart device and ... for patient safety and research quality. ... quality, and delivery with innovative technology," said ...
(Date:12/17/2014)... , Dec. 16, 2014 Research and Markets ... addition of the "Global Chemical Sensor Market ... http://photos.prnewswire.com/prnh/20130307/600769 One ... increasing demand for medical sensors in biomedical applications. ... for quick and correct diagnosis during surgical procedures. ...
(Date:12/15/2014)... , Dec. 12, 2014 Research and ... the addition of the "Global Facial Recognition ... http://photos.prnewswire.com/prnh/20130307/600769 ... identification of individuals. Facial recognition system measures the ... nose, jaw edges, mouth, and the distance between ...
Breaking Biology News(10 mins):HITLAB Completes GCP Audit for FDA Smart Device & App Compliance 2Global Chemical Sensor Market 2015-2019: Key Vendors are Abbott Laboratories, Bayer, Hoffmann La-Roche, Johnson & Johnson, NGK Spark Plugs and Robert Bosch 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 2Global Facial Recognition Market 2015-2019: Key Vendors are 3M Cogent, Cognitec Systems, NEC and Safran Group 3
... The scientists, working together in a project called PLANTS, ... technology and people to continuously assess the state of ... system monitors the state of the crop on a ... to a broader vision where the virtual (computing) space ...
... researchers are working toward a future in which each ... how oncologists should treat the cancer to obtain the ... patients with prostate cancer should receive extra therapy after ... an indolent disease that does not even require surgery. ...
... antibiotic commonly used to treat a variety of serious infections ... a test-tube study of human brain cells by Johns Hopkins ... Results of the lab study with ceftriaxone are expected to ... meeting on April 5 in San Diego, Calif. , Rumbaugh ...
Cached Biology News:New crop of technology reveals plant health 2New crop of technology reveals plant health 3Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers 2Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers 3Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers 4Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers 5Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers 6Markers of gene, protein, or micro-RNA activity predict outcome in prostate and colorectal cancers 7Hopkins study suggests commercially available antibiotic may help fight dementia in HIV patients 2
(Date:12/22/2014)... N.C. , Dec. 22, 2014  Alternative ... announced that it has signed a letter of ... that has developed and patented a nanotechnology-based development ... diagnostics products that enable rapid on-site collection and ... use/abuse and health issues in an immediate, non-invasive ...
(Date:12/22/2014)... VIEJO, Calif. , Dec. 22, 2014  ( ... that CoPatient, an online medical bill review and advocacy ... offering in the FREE WellCard Savings discount health services ... medical bill that was more than they expected to ... members reduce health care costs, WellCard Savings is pleased ...
(Date:12/22/2014)... Chicago, Illinois (PRWEB) December 22, 2014 ... representing tenants and occupiers of commercial real estate, has ... two new offices in Perth and Brisbane, Western Australia, ... board of directors. , ITRA Global / ACORPP ... and totally independent consultancy company providing property services to ...
(Date:12/19/2014)... and Hershey, PA (PRWEB) December 19, 2014 ... BJCT), a leading developer and manufacturer of needle-free ... into an agreement with Immunomic Therapeutics, Inc. (“ITI”) ... needle-free injection device with its LAMP™ vaccine platform. ... option for an exclusive Worldwide license to the ...
Breaking Biology Technology:ALNE Announces Intention To Acquire BioTechPharma 2WellCard Savings Announces CoPatient Medical Bill Review Service for Members 2ITRA Global Continues International Expansion in Perth and Brisbane, Australia 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3
... Inc. announced today Winchester Hospital ... of APIs suite of labor resource management solutions ... include Payrollmation time and attendance, ActiveStaffer staff scheduling, ... , ,The hospital is adopting the applications in ...
... MILWAUKEE - Merge eFilm , a global ... the release of eFilm Workstation 1.9 and ... PACS for 10 imaging centers. , ,eFilm Workstation ... the ability to view and manipulate digital diagnostic ...
... long-standing riddle of whether the Earth's ice ages occurred simultaneously ... the glacial deposits found in the high desert east of ... effects of cosmic rays on minerals found in boulders carried ... of scientists from the University of Wisconsin-Madison has demonstrated that ...
Cached Biology Technology:Glacial records depict ice age climate in synch worldwide 2Glacial records depict ice age climate in synch worldwide 3
SRY (sex determining region Y)-box 10...
geminin, DNA replication inhibitor...
Normal human serum, single donor...
One-step, microplate or cuvet, colorimetric, linear detection range 0.1 mg/dL to 100 mg/dL. Procedure: 20 min....
Biology Products: