Navigation Links
New compound reduces stroke damage

A group of German scientists has synthesized a new compound that dramatically decreases the damage to neurons in rats demonstrating stroke symptoms. The research appears as the "Paper of the Week" in the May 26 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal.

Stroke is the third leading cause of death in the United States and the most common cause of adult disability. An ischemic stroke occurs when a cerebral vessel occludes, obstructing blood flow to a portion of the brain. Currently, there is only one approved stroke therapy, tissue plasminogen activator, which targets the thrombus within the blood vessel. Because of the lack of available stroke treatments, neuroprotective agents have also generated as much interest as thrombolytic therapies.

The immunosuppressive drug FK506 (also known as Tacrolimus or Prograf®) is often administered to patients receiving transplants to prevent organ rejection. Dervatives of the drug are also commonly used in the treatment of autoimmune diseases. FK506 inhibits T-cell activation by binding to members of the FK506-binding protein (FKBP) family. Interestingly, FK506, and several molecules with similar structures, also demonstrate neuroprotective and neuroregenerative effects in a wide range of animal models mimicking Parkinson's disease, dementia, stroke, and nerve damage.

Gunter Fischer and his colleagues at the Max-Planck Research Unit for Enzymology of Protein Folding in Germany have now determined that neuroprotective FK506 derivatives specifically target a receptor called FKBP38. "High FKBP38 activity in neuronal cells triggers mechanisms leading to programmed cell death," explains Fischer. "Inhibition of FKBP38 makes cells more predisposed to survive."

The scientists also synthesized a molecule that specifically inhibits FKBP38 and administered it to rats that were experiencing stroke symptoms. "We developed a lead compound that
'"/>

Source:American Society for Biochemistry and Molecular Biology


Page: 1 2

Related biology news :

1. Researchers discover chemical compounds that affect plant growth
2. Bacterial genome sheds light on synthesizing cancer-fighting compounds
3. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
4. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
5. Novel compounds show promise as safer, more potent insecticides
6. Metal-containing compounds show promise as HIV weapon
7. Natural compound from pond scum shows potential activity against Alzheimers
8. Chemical compound inhibits tumor growth, size in new mouse study
9. Seaweed yields new compounds with pharmaceutical potential
10. Phenolic compounds may explain Mediterranean diet benefits
11. UC Berkeley researchers create a biologically-inspired artificial compound eye
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New compound reduces stroke damage

(Date:9/16/2014)... has its own bacterial identity. That,s the conclusion of ... who studied the genetic fingerprints of bacteria on 57 ... "This study demonstrates for the first time that host ... strategies possess very different microbial communities on their leaves," ... researcher in the UO,s Institute of Ecology and Evolution ...
(Date:9/16/2014)... new school year, a new football season and another ... September, SpaceX,s Dragon spacecraft is scheduled to blast off ... part of the company,s fourth contracted mission to the ... third suite of research investigations sponsored by the Center ... the role of managing the U.S. National Laboratory on ...
(Date:9/16/2014)... vessel returned to Spain culminating the around the world ... picture of how the global ocean works and what ... from the atmosphere is not limited to coastal areas, ... the planet, and it is already affecting the ocean ... in CSIC Residence for Researchers in Barcelona, in a ...
Breaking Biology News(10 mins):Microbiome research shows each tree species has a unique bacterial identity 2CASIS research set for launch aboard SpaceX mission to space station 2CASIS research set for launch aboard SpaceX mission to space station 3The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3
... Columbia University Medical,Center have discovered a way to overcome ... its tendency to kill normal cells in the,process of ... Jan. 25 issue of the Proceedings of the,National Academy ... by incorporating it into a specially designed,virus. The virus ...
... unlock the secret to quicker, more effective treatment of TB ... bacteria are active again, the disease becomes treatable using common ... of this protein will lead the way to designing drugs ... In England and Wales around 400 people die each year ...
... been trying to establish the cause of a repulsive ... DNA and other biomolecules, when they are very close ... know as hydration force. , Jordi Faraudo, a researcher ... de Barcelona, and Fernando Bresme of the Department of ...
Cached Biology News:Columbia research lifts major hurdle to gene therapy for cancer 2UAB scientists discover the origin of a mysterious physical force 2
(Date:9/17/2014)... 2014 The Pistoia Alliance, a ... the barriers to innovation in life sciences R&D ... Carmen Nitsche as Executive Director Business Development North ... global reach. , Carmen joins the Pistoia Alliance ... Development. At Accelrys, she managed various life sciences ...
(Date:9/16/2014)... energy from jaw movements has been created by a ... that the device can generate electricity from eating, chewing ... or wearable electronic devices, such as hearing aids, cochlear ... first results of the device,s performance have been published ... Materials and Structures . , Jaw movements have proved ...
(Date:9/16/2014)... for radar domes have now refined the technology to ... The new work by Rice chemist James Tour and ... skyscrapers free of ice and fog while retaining their ... was introduced this month in the American Chemical Society ... The material is made of graphene nanoribbons, atom-thick strips ...
(Date:9/16/2014)... 16, 2014 CIRTEC Medical Systems’ Board ... as CEO of CIRTEC. , “I am delighted ... the Company.” noted Brian Highley. “The company has made ... strong organic growth over the past two years. The ... to improve and expand the services Cirtec offers its ...
Breaking Biology Technology:Pistoia Alliance Expands Business Development with Appointment of Carmen Nitsche 2'Smart material' chin strap harvests energy from chewing 2Nanoribbon film keeps glass ice-free 2
... efficient: BASF research scientists are helping to revolutionize ... aid of three-dimensional photonic crystals. In a three-year ... these crystals together with partners such as Hanover ... the Technical University of Denmark and the Ecole ...
... Sangamo,BioSciences, Inc. (Nasdaq: SGMO ) announced today that ... on the progress of,Sangamo,s ZFP Therapeutic development programs and ... (ET) on Wednesday, November 28,2007 at the Piper Jaffray ... The presentation will be webcast live and may be ...
... Nov. 20 China Biopharma,Inc. (OTC Bulletin Board: ... take closer control and to better improve its ... away from the increasingly competitive and,low margin vaccine ... "We plan to take more control on the ...
Cached Biology Technology:3-D photonic crystals will revolutionize telecommunications 23-D photonic crystals will revolutionize telecommunications 3Sangamo BioSciences to Present at the Piper Jaffray Health Care Conference 2China Biopharma, Inc. Announces New Plan of Operation 2
SHEEP ANTI HUMAN CATHEPSIN G...
MOUSE ANTI BOVINE CD335:ALEXA 488 Immunogen: Fusion protein consisting of the extracellular region of bovine CD335....
Template and primers for preparation of internal control spots...
AedestaTM Animal Organ/Tissue Perfusion Soln....
Biology Products: