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New compound protects against liver cancer

derived from oleanolic acid, CDDO-Im also has strong anti-inflammatory properties, which the researchers say makes it ideally suited to the prevention of certain cancers. "When cells become inflamed, they can produce reactive molecules, called free radicals, that can damage DNA and promote cancer development," explained Kensler. "CDDO-Im can also inhibit cancer formation by interfering with this inflammatory process."

Because it can stimulate the body's defense mechanisms at such low doses, Kensler believes that CDDO-Im is an excellent candidate for cancer prevention in humans. "If this compound can produce such a potent and dramatic reduction in the number of pre-cancerous growths, it should have an equally dramatic impact on the development of actual cancers. This study suggests that we may be on the right track in terms of chemoprevention. It may open the door for a new class of compounds that could prevent a number of diseases," said Kensler.


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Source:Johns Hopkins University Bloomberg School of Public Health


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