Navigation Links
New compound protects against liver cancer

Scientists have identified a new compound called CDDO-Im that protects against the development of liver cancer in laboratory animals. Experiments, led by researchers at the Johns Hopkins Bloomberg School of Public Health, show CDDO-Im to be effective at doses 100 times lower than other compounds known to prevent cancer in people. Because of its makeup, the researchers believe CDDO-Im could be particularly effective in preventing cancers with a strong link to inflammation, such as liver, colon, prostate and gastric cancers. It could also play a role in preventing diseases such as neurodegeneration, asthma and emphysema. The findings are featured in the February 15, 2006, issue of the journal Cancer Research.

CDDO-Im is a synthetic compound that belongs to a class of cancer-fighting compounds called triterpenoids under development by Dr. Michael Sporn and other study co-authors at Dartmouth Medical School. It is derived from oleanolic acid, a naturally occurring substance found in many plants. Other oleanolic derivatives are known to reduce tumor growth in animals and humans.

Researchers believe CDDO-Im works by activating Nrf2, a master switch known to direct certain enzymes to stimulate the cell's defense mechanisms and remove harmful chemicals from cells. "Activation of the Nrf2 pathway with CDDO-Im could provide protection against a number of diseases triggered by environmental agents," said Thomas Kensler, PhD, a professor with the Bloomberg School's Department of Environmental Health Sciences and lead author of the study.

In their research, Kensler and his colleagues treated laboratory rats with varying doses of CDDO-Im. Two days after treatment with CDDO-Im, the rats were given aflatoxin, a naturally occurring cancer-causing toxin. CDDO-Im treatment led to an 85 percent reduction in pre-cancerous lesions at the lowest dose of 50 micrograms per rat and a 99 percent reduction at the highest dose of 5 milligrams.

Like other compounds
'"/>

Source:Johns Hopkins University Bloomberg School of Public Health


Page: 1 2

Related biology news :

1. Researchers discover chemical compounds that affect plant growth
2. Bacterial genome sheds light on synthesizing cancer-fighting compounds
3. Scientists discover the bodys marijuana-like compounds are crucial for stress-induced pain relief
4. Evolution of taste receptor may have shaped human sensitivity to toxic compounds
5. Novel compounds show promise as safer, more potent insecticides
6. Metal-containing compounds show promise as HIV weapon
7. Natural compound from pond scum shows potential activity against Alzheimers
8. Chemical compound inhibits tumor growth, size in new mouse study
9. Seaweed yields new compounds with pharmaceutical potential
10. Phenolic compounds may explain Mediterranean diet benefits
11. UC Berkeley researchers create a biologically-inspired artificial compound eye
Post Your Comments:
*Name:
*Comment:
*Email:
TAG: New compound protects against liver cancer

(Date:7/11/2014)... members to reduce aggression and gain access to scarce ... activities shows a certain pattern across the day. The ... Biology Letters . , Grooming between individuals in a ... To be groomed has hygienic benefits and is stress ... provide access to infants, mating opportunities and high quality ...
(Date:7/11/2014)... have explored two different ways that allow unprecedented ... the formation of oxygen molecules in photosynthesis. The ... journal Nature Communications . , "The new ... for water oxidation, which are key components for ... of solar energy in fuels like hydrogen, ethanol ...
(Date:7/11/2014)... kidney injury related to the use of hydroxyethyl starch ... molecules, according to a report in Anesthesia & ... Society (IARS). , The "total mass of HES molecules" ... renal proximal tubule cells (PTCs), concludes the laboratory study ... Wrzburg, Austria. Other factorssuch as differences in the ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... new study on identifying which patients were likely to ... found that measuring how a certain non-toxic dye was ... accurate indicator of liver function, and therefore a reliable ... used a simple non-invasive device to measure the dye, ...
... predators at the top of the marine food chain, ... mercury in their bodies. A new study has found ... albatross species that forage in different areas of the ... and DDT have increased in both species over the ...
... ago, humans began scrubbing off and discarding the outer ... beneath. Now, for the first time, scientists in Japan ... called rice bran, significantly lowers blood pressure in rats ... reports their findings in the March 8 issue of ...
Cached Biology News:Predicting successful outcomes in living-donor liver transplants 2Predicting successful outcomes in living-donor liver transplants 3Albatross study shows regional differences in ocean contamination 2Albatross study shows regional differences in ocean contamination 3How nice, brown rice: Study shows rice bran lowers blood pressure in rats 2
(Date:7/11/2014)... WEST PALM BEACH, Fla. , July 11, 2014 ... wide variety of high-quality peptides that are used solely ... online. To honor two successful years in business, Maxim ... Performance LLC, has just launched a new and updated ... addition, the research blog section has been updated with ...
(Date:7/11/2014)... DUBLIN , July 11, 2014 ... "International Transfection Technology Market - Global Industry Analysis, ... report to their offering. ... to introduce nucleic acids (either DNA or RNA) into ... therapy, mutation of cancer cells and protein metabolism by ...
(Date:7/11/2014)... -- EPFL and the University of  Geneva ... John P. Donoghue . The American neuroscientist is to ... The new Wyss Center for Bio- and ... , has named as its director one of ... , founder of Brown University,s Institute for Brain Science, ...
(Date:7/11/2014)...  Researchers have pioneered a revolutionary new way ... called Virtual Finger, allows scientists to move through ... synapses using the flat surface of their computer ... studies orders of magnitude more efficient, saving time, ... many areas of experimental biology. The software and ...
Breaking Biology Technology:Maxim Peptide Celebrates Second Anniversary Online with an Updated Website and Special Deals Section 2International Transfection Technology Market - Industry Analysis, Size, Share, Growth, Trends and Forecast to 2019 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 2John P. Donoghue is Taking the Lead at the Wyss Center and is Appointed Professor at EPFL and University of Geneva 3Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3
... provide cost-efficient, easy to use ... sputum samples for testing, ALBUQUERQUE, N.M., Feb. 13 ... patented early lung cancer detection,testing and other cancer diagnostic ... to collect lung sputum,samples in an upcoming clinical study ...
... therapeutic antibody to be presented at AACR ... Special Conference on Cancer Stem Cells -, TORONTO, ... company discovering and developing the next wave of,antibody therapeutics, today ... cancer stem cell antibody will be,presented at the AACR Special ...
... Cellegy,Pharmaceuticals, Inc. (OTC Bulletin Board: CLGY) today ... merger agreement providing for the,acquisition of Cellegy ... held specialty pharmaceuticals company that is engaged ... for the prevention,of viral infections, including influenza. ...
Cached Biology Technology:Biomoda and Medical Acoustics Partner in Study for Early Detection of Lung Cancer in Veterans 2Biomoda and Medical Acoustics Partner in Study for Early Detection of Lung Cancer in Veterans 3ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 2ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 3ARIUS presents new findings showing therapeutic antibody inhibits human leukemic cancer stem cells 4Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 2Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 3Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 4Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 5Cellegy Pharmaceuticals Announces Signing of Definitive Merger Agreement 6
... many modifications to the original formulas in efforts ... play an important role in tissue,culture. A salt ... osmotic balance in the medium and to provide ... is as valuable today as when it was ...
Imject Freund's Complete Adjuvant (FCA)...
... long and short-term enriched housing for nonhuman ... quarantine and non-quarantine settings on a per ... utilizing our state-of-the-art social housing and nursery ... on site CDC quarantine facilities. Primate ...
... exceptionally sensitive nucleic acid gel stain has bright ... in gels, making it ideal for detecting dsDNA ... transilluminators. SYBR Green I nucleic gel acid ... electrophoresis, real-time PCR assays and bandshift assays. One ...
Biology Products: