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New compound prevents alcoholic behavior, relapse in animals by blocking stress response

ibility to relapse under stress. Yet the compound did not affect their native curiosity or lower levels of drinking alcohol in rats that were not alcohol-dependent.

In addition to alcoholism, the compound may prove to be useful in the treatment of depression or anxiety disorders, in which CRF levels can be especially high.

The compound or similar molecules can be given orally, reach the brain in sufficient amounts to block more than 90 percent of certain brain CRF receptors, and do not accumulate in other organs, most importantly the liver, in ways that would cause concerns about potential side effects, says Heilig.
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Source:Society for Neuroscience


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